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Antibiotic   Tobramycin sulfate  
injection
aerosol Eye-drops Oral solution
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Bactob India
Beltob India
Bramicil Italy
Brulamycin Germany, Hungary
Eltol India
Fytobra India
Gernebcin Germany
Komitob India
Nebcin Australia, Egypt, Great Britain, Greece, New Zealand, Republic of South Africa, Saudi Arabia
Nebcina Denmark, Morocco, Norway, Sweden
Nebcine France, Morocco
Nebicina Italy
Obracin Belgium, Luxembourg, Netherlands, Switzerland
Tobel Turkey
Tobra Germany
Tobra-Gobens Spain
Tobraalex Egypt
Tobracin Egypt
Tobradistin Spain
Tobramicina Italy, Portugal, Spain
Tobramina Brazil
Tobramycin Australia, Canada, Germany, Great Britain, Ireland, Norway, United States of America
Tobramycine Belgium, Luxembourg, Netherlands
Tobrasix Austria
Tobrazid Germany
Tomycin Finland
Stability in solutions   injection   Stability in solutions : Tobramycin sulfate     
Container Solvent Concentration Temperature Storage Duration of stability References
Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,2 mg/ml -20°C Protect from light
28 Day
565
Level of evidence D
Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,2 mg/ml 25°C Light
48 Hour
434

Polyvinyl chloride NaCl 0,9% or Glucose 5% 1,2 mg/ml 4°C Protect from light
48 Hour
434

Polyvinyl chloride Sodium chloride 0,9% 1 & 10 mg/ml 25°C Not specified
3 Day
13
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 1 & 10 mg/ml 5°C Protect from light
14 Day
13
Level of evidence B
Polyvinyl chloride Glucose 5% 3,2 mg/ml -20°C Protect from light
30 Day
575
Biological analysis
Ethylene vinyl acetate Sodium chloride 0,9% 0,95 mg/ml 23°C Protect from light
7 Day
1704
Level of evidence A+
Ethylene vinyl acetate Sodium chloride 0,9% 0,95 mg/ml 4°C Protect from light
30 Day
1704
Level of evidence A+
Polypropylen Syringe Water for Injection 40 mg/ml 25°C Not specified
60 Day
709
Biological analysis
Polypropylen Syringe Water for Injection 40 mg/ml 4°C Protect from light
60 Day
709
Biological analysis
Polypropylen Syringe Sodium chloride 0,9% 30 mg/ml 22°C-23°C Light
48 Hour
639
Level of evidence D
Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0,5 & 5 mg/ml 25°C Not specified
24 Hour
604
Manufacturer's stability data
Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0,5 & 5 mg/ml 4°C Protect from light
10 Day
604
Manufacturer's stability data
  Mentions Légales