Last update :
19/11/2024
References   References 300  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/54/11/1287

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Gilbert DL, Martinez JF.
Title : Compatibility of propofol injectable emulsion with selected drugs during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ; 54: 1287-1292. 1997

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
injectionAciclovir sodium Antiviral
Compatible 7 mg/ml + injectionPropofol 10 mg/ml + None
injectionAlfentanil hydrochloride Analgesic
Compatible 500 µg/ml + injectionPropofol 10 mg/ml + None
injectionAmikacin sulfate Antibiotic
Incompatible 5 mg/ml + injectionPropofol 10 mg/ml + None
injectionAminophylline Various
Compatible 2.5 mg/ml + injectionPropofol 10 mg/ml + None
injectionAmphotericin B Antifungal
Incompatible 0.6 mg/ml + injectionPropofol 10 mg/ml + None
injectionAmpicillin sodium Antibiotic
Compatible 20 mg/ml + injectionPropofol 10 mg/ml + None
injectionAtracurium besylate Curarimimetic
Incompatible 10 mg/ml + injectionPropofol 10 mg/ml + None
injectionAtropine sulfate Antimuscarinic
Compatible 0.1 mg/ml + injectionPropofol 10 mg/ml + None
injectionAztreonam Antibiotic
Compatible 40 mg/ml + injectionPropofol 10 mg/ml + None
injectionBretylium tosilate Anti-arrhythmic
Incompatible 50 mg/ml + injectionPropofol 10 mg/ml + None
injectionBumetanide Diuretic
Compatible 0.04 mg/ml + injectionPropofol 10 mg/ml + None
injectionBuprenorphine hydrochloride Analgesic
Compatible 0.04 mg/ml + injectionPropofol 10 mg/ml + None
injectionButorphanol tartrate Analgesic
Compatible 0.04 mg/ml + injectionPropofol 10 mg/ml + None
injectionCalcium chloride Electrolyte
Incompatible 40 mg/ml + injectionPropofol 10 mg/ml + None
injectionCalcium gluconate Electrolyte
Compatible 40 mg/ml + injectionPropofol 10 mg/ml + None
injectionCarboplatin Anticancer drug
Compatible 5 mg/ml + injectionPropofol 10 mg/ml + None
injectionCefazolin sodium Antibiotic
Compatible 20 mg/ml + injectionPropofol 10 mg/ml + None
injectionCefonicid sodium Antibiotic
Compatible 20 mg/ml + injectionPropofol 10 mg/ml + None
injectionCefoperazone sodium Antibiotic
Compatible 40 mg/ml + injectionPropofol 10 mg/ml + None
injectionCefotaxime sodium Antibiotic
Compatible 20 mg/ml + injectionPropofol 10 mg/ml + None
injectionCefoxitin sodium Antibiotic
Compatible 20 mg/ml + injectionPropofol 10 mg/ml + None
injectionCeftazidime Antibiotic
Compatible 40 mg/ml + injectionPropofol 10 mg/ml + None
injectionCeftizoxime sodium Antibiotic
Compatible 20 mg/ml + injectionPropofol 10 mg/ml + None
injectionCeftriaxone disodium Antibiotic
Compatible 20 mg/ml + injectionPropofol 10 mg/ml + None
injectionCefuroxime sodium Antibiotic
Compatible 30 mg/ml + injectionPropofol 10 mg/ml + None
injectionChlorpromazine hydrochloride Anxiolytic
Compatible 2 mg/ml + injectionPropofol 10 mg/ml + None
injectionCiclosporin Immunosuppressant
Compatible 5 mg/ml + injectionPropofol 10 mg/ml + None
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + injectionPropofol 10 mg/ml + None
injectionCiprofloxacin lactate Antibiotic
Compatible 1 mg/ml + injectionPropofol 10 mg/ml + None
injectionCisplatin Anticancer drug
Compatible 1 mg/ml + injectionPropofol 10 mg/ml + None
injectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + injectionPropofol 10 mg/ml + None
injectionCyclophosphamide Anticancer drug
Compatible 10 mg/ml + injectionPropofol 10 mg/ml + None
injectionCytarabine Anticancer drug
Compatible 50 mg/ml + injectionPropofol 10 mg/ml + None
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + injectionPropofol 10 mg/ml + None
injectionDiazepam Anxiolytic
Incompatible 5 mg/ml + injectionPropofol 10 mg/ml + None
injectionDigoxin Cardiotonic
Compatible 250 µg/ml + injectionPropofol 10 mg/ml + None
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + injectionPropofol 10 mg/ml + None
injectionDobutamine hydrochloride Cardiotonic
Compatible 4 mg/ml + injectionPropofol 10 mg/ml + None
injectionDopamine hydrochloride Cardiotonic
Compatible 3.2 mg/ml + injectionPropofol 10 mg/ml + None
injectionDoxorubicin hydrochloride Anticancer drug
Compatible 2 mg/ml + injectionPropofol 10 mg/ml + None
injectionDoxycycline hyclate Antibiotic
Compatible 1 mg/ml + injectionPropofol 10 mg/ml + None
injectionDroperidol Neuroleptic
Compatible 0.4 mg/ml + injectionPropofol 10 mg/ml + None
injectionEnalaprilate Antihypertensive
Compatible 0.1 mg/ml + injectionPropofol 10 mg/ml + None
injectionEphedrine hydrochloride Sympathomimetic
Compatible 5 mg/ml + injectionPropofol 10 mg/ml + None
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 100 µg/ml + injectionPropofol 10 mg/ml + None
injectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + injectionPropofol 10 mg/ml + None
injectionFamotidine Antihistamine (H2)
Compatible 2 mg/ml + injectionPropofol 10 mg/ml + None
injectionFentanyl citrate Analgesic
Compatible 50 µg/ml + injectionPropofol 10 mg/ml + None
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionPropofol 10 mg/ml + None
injectionFluorouracil Anticancer drug
Compatible 16 mg/ml + injectionPropofol 10 mg/ml + None
injectionFurosemide Diuretic
Compatible 3 mg/ml + injectionPropofol 10 mg/ml + None
injectionGanciclovir sodium Antiviral
Compatible 20 mg/ml + injectionPropofol 10 mg/ml + None
injectionGentamicin sulfate Antibiotic
Incompatible 5 mg/ml + injectionPropofol 10 mg/ml + None
injectionGlycopyrronium bromide Antimuscarinic
Compatible 0.2 mg/ml + injectionPropofol 10 mg/ml + None
injectionGranisetron hydrochloride Antiemetic
Compatible 0.05 mg/ml + injectionPropofol 10 mg/ml + None
injectionHaloperidol lactate Neuroleptic
Compatible 0.2 mg/ml + injectionPropofol 10 mg/ml + None
injectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + injectionPropofol 10 mg/ml + None
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1 mg/ml + injectionPropofol 10 mg/ml + None
injectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + injectionPropofol 10 mg/ml + None
injectionHydroxyzine dihydrochloride Anxiolytic
Compatible 2 mg/ml + injectionPropofol 10 mg/ml + None
injectionIfosfamide Anticancer drug
Compatible 25 mg/ml + injectionPropofol 10 mg/ml + None
injectionImipenem - cilastatin sodium Antibiotic
Compatible 10 mg/ml + injectionPropofol 10 mg/ml + None
injectionInsulin Glucose-lowering
Compatible 1 UI/ml + injectionPropofol 10 mg/ml + None
injectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0.004 mg/ml + injectionPropofol 10 mg/ml + None
injectionKetamine hydrochloride General anesthetic
Compatible 10 mg/ml + injectionPropofol 10 mg/ml + None
injectionLabetalol hydrochloride Beta-blocker
Compatible 5 mg/ml + injectionPropofol 10 mg/ml + None
injectionLidocaine hydrochloride Local anesthetic
Compatible 10 mg/ml + injectionPropofol 10 mg/ml + None
injectionLorazepam Anxiolytic
Compatible 0.1 mg/ml + injectionPropofol 10 mg/ml + None
injectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + injectionPropofol 10 mg/ml + None
injectionMannitol Various
Compatible 150 mg/ml + injectionPropofol 10 mg/ml + None
injectionMethotrexate sodium Anticancer drug
Incompatible 15 mg/ml + injectionPropofol 10 mg/ml + None
injectionMethylprednisolone sodium succinate Anti-inflammatory
Incompatible 5 mg/ml + injectionPropofol 10 mg/ml + None
injectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + injectionPropofol 10 mg/ml + None
injectionMidazolam hydrochloride Anxiolytic
Compatible 2 mg/ml + injectionPropofol 10 mg/ml + None
injectionMinocycline hydrochloride Antibiotic
Incompatible 0.2 mg/ml + injectionPropofol 10 mg/ml + None
injectionMitoxantrone dihydrochloride Anticancer drug
Incompatible 0.5 mg/ml + injectionPropofol 10 mg/ml + None
injectionMorphine sulfate Analgesic
Compatible 1 mg/ml + injectionPropofol 10 mg/ml + None
injectionNafcillin sodium Antibiotic
Compatible 20 mg/ml + injectionPropofol 10 mg/ml + None
injectionNalbuphine hydrochloride Antidote
Compatible 10 mg/ml + injectionPropofol 10 mg/ml + None
injectionNaloxone hydrochloride Antidote
Compatible 0.4 mg/ml + injectionPropofol 10 mg/ml + None
injectionNetilmicin sulfate Antibiotic
Incompatible 5 mg/ml + injectionPropofol 10 mg/ml + None
injectionNitroglycerin Vasodilator
Compatible 0.4 mg/ml + injectionPropofol 10 mg/ml + None
injectionNitroprusside sodium Vasodilator
Compatible 0.4 mg/ml + injectionPropofol 10 mg/ml + None
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 0.016 mg/ml + injectionPropofol 10 mg/ml + None
injectionOfloxacin Antibiotic
Compatible 4 mg/ml + injectionPropofol 10 mg/ml + None
injectionPaclitaxel Anticancer drug
Compatible 1.2 mg/ml + injectionPropofol 10 mg/ml + None
injectionPancuronium bromide Curarimimetic
Compatible 1 mg/ml + injectionPropofol 10 mg/ml + None
injectionPentobarbital sodium General anesthetic
Compatible 5 mg/ml + injectionPropofol 10 mg/ml + None
injectionPethidine hydrochloride Analgesic
Compatible 4 mg/ml + injectionPropofol 10 mg/ml + None
injectionPhenobarbital sodium Antiepileptic
Compatible 5 mg/ml + injectionPropofol 10 mg/ml + None
injectionPhenylephrine hydrochloride Sympathomimetic
Compatible 0.1 mg/ml + injectionPropofol 10 mg/ml + None
injectionPhenytoin sodium Antiepileptic
Incompatible 50 mg/ml + injectionPropofol 10 mg/ml + None
injectionPiperacillin sodium Antibiotic
Compatible 40 mg/ml + injectionPropofol 10 mg/ml + None
injectionPotassium chloride Electrolyte
Compatible 100 mEq/l + injectionPropofol 10 mg/ml + None
injectionProchlorperazine edysilate Neuroleptic
Compatible 0.5 mg/ml + injectionPropofol 10 mg/ml + None
injectionPropofol General anesthetic
Compatible 10 mg/ml + injectionAciclovir sodium 7 mg/ml + None
Compatible 10 mg/ml + injectionAlfentanil hydrochloride 500 µg/ml + None
Incompatible 10 mg/ml + injectionAmikacin sulfate 5 mg/ml + None
Compatible 10 mg/ml + injectionAminophylline 2.5 mg/ml + None
Incompatible 10 mg/ml + injectionAmphotericin B 0.6 mg/ml + None
Compatible 10 mg/ml + injectionAmpicillin sodium 20 mg/ml + None
Incompatible 10 mg/ml + injectionAtracurium besylate 10 mg/ml + None
Compatible 10 mg/ml + injectionAtropine sulfate 0.1 mg/ml + None
Compatible 10 mg/ml + injectionAztreonam 40 mg/ml + None
Incompatible 10 mg/ml + injectionBretylium tosilate 50 mg/ml + None
Compatible 10 mg/ml + injectionBumetanide 0.04 mg/ml + None
Compatible 10 mg/ml + injectionBuprenorphine hydrochloride 0.04 mg/ml + None
Compatible 10 mg/ml + injectionButorphanol tartrate 0.04 mg/ml + None
Incompatible 10 mg/ml + injectionCalcium chloride 40 mg/ml + None
Compatible 10 mg/ml + injectionCalcium gluconate 40 mg/ml + None
Compatible 10 mg/ml + injectionCarboplatin 5 mg/ml + None
Compatible 10 mg/ml + injectionCefazolin sodium 20 mg/ml + None
Compatible 10 mg/ml + injectionCefonicid sodium 20 mg/ml + None
Compatible 10 mg/ml + injectionCefoperazone sodium 40 mg/ml + None
Compatible 10 mg/ml + injectionCefotaxime sodium 20 mg/ml + None
Compatible 10 mg/ml + injectionCefoxitin sodium 20 mg/ml + None
Compatible 10 mg/ml + injectionCeftazidime 40 mg/ml + None
Compatible 10 mg/ml + injectionCeftizoxime sodium 20 mg/ml + None
Compatible 10 mg/ml + injectionCeftriaxone disodium 20 mg/ml + None
Compatible 10 mg/ml + injectionCefuroxime sodium 30 mg/ml + None
Compatible 10 mg/ml + injectionChlorpromazine hydrochloride 2 mg/ml + None
Compatible 10 mg/ml + injectionCiclosporin 5 mg/ml + None
Compatible 10 mg/ml + injectionCimetidine hydrochloride 12 mg/ml + None
Compatible 10 mg/ml + injectionCiprofloxacin lactate 1 mg/ml + None
Compatible 10 mg/ml + injectionCisplatin 1 mg/ml + None
Compatible 10 mg/ml + injectionClindamycin phosphate 10 mg/ml + None
Compatible 10 mg/ml + injectionCyclophosphamide 10 mg/ml + None
Compatible 10 mg/ml + injectionCytarabine 50 mg/ml + None
Compatible 10 mg/ml + injectionDexamethasone sodium phosphate 1 mg/ml + None
Incompatible 10 mg/ml + injectionDiazepam 5 mg/ml + None
Compatible 10 mg/ml + injectionDigoxin 250 µg/ml + None
Compatible 10 mg/ml + injectionDiphenhydramine hydrochloride 2 mg/ml + None
Compatible 10 mg/ml + injectionDobutamine hydrochloride 4 mg/ml + None
Compatible 10 mg/ml + injectionDopamine hydrochloride 3.2 mg/ml + None
Compatible 10 mg/ml + injectionDoxorubicin hydrochloride 2 mg/ml + None
Compatible 10 mg/ml + injectionDoxycycline hyclate 1 mg/ml + None
Compatible 10 mg/ml + injectionDroperidol 0.4 mg/ml + None
Compatible 10 mg/ml + injectionEnalaprilate 0.1 mg/ml + None
Compatible 10 mg/ml + injectionEphedrine hydrochloride 5 mg/ml + None
Compatible 10 mg/ml + injectionEpinephrine hydrochloride 100 µg/ml + None
Compatible 10 mg/ml + injectionEsmolol hydrochloride 10 mg/ml + None
Compatible 10 mg/ml + injectionFamotidine 2 mg/ml + None
Compatible 10 mg/ml + injectionFentanyl citrate 50 µg/ml + None
Compatible 10 mg/ml + injectionFluconazole 2 mg/ml + None
Compatible 10 mg/ml + injectionFluorouracil 16 mg/ml + None
Compatible 10 mg/ml + injectionFurosemide 3 mg/ml + None
Compatible 10 mg/ml + injectionGanciclovir sodium 20 mg/ml + None
Incompatible 10 mg/ml + injectionGentamicin sulfate 5 mg/ml + None
Compatible 10 mg/ml + injectionGlycopyrronium bromide 0.2 mg/ml + None
Compatible 10 mg/ml + injectionGranisetron hydrochloride 0.05 mg/ml + None
Compatible 10 mg/ml + injectionHaloperidol lactate 0.2 mg/ml + None
Compatible 10 mg/ml + injectionHeparin sodium 100 UI/ml + None
Compatible 10 mg/ml + injectionHydrocortisone sodium succinate 1 mg/ml + None
Compatible 10 mg/ml + injectionHydromorphone hydrochloride 0.5 mg/ml + None
Compatible 10 mg/ml + injectionHydroxyzine dihydrochloride 2 mg/ml + None
Compatible 10 mg/ml + injectionIfosfamide 25 mg/ml + None
Compatible 10 mg/ml + injectionImipenem - cilastatin sodium 10 mg/ml + None
Compatible 10 mg/ml + injectionInsulin 1 UI/ml + None
Compatible 10 mg/ml + injectionIsoprenaline hydrochloride 0.004 mg/ml + None
Compatible 10 mg/ml + injectionKetamine hydrochloride 10 mg/ml + None
Compatible 10 mg/ml + injectionLabetalol hydrochloride 5 mg/ml + None
Compatible 10 mg/ml + injectionLidocaine hydrochloride 10 mg/ml + None
Compatible 10 mg/ml + injectionLorazepam 0.1 mg/ml + None
Compatible 10 mg/ml + injectionMagnesium sulfate 100 mg/ml + None
Compatible 10 mg/ml + injectionMannitol 150 mg/ml + None
Incompatible 10 mg/ml + injectionMethotrexate sodium 15 mg/ml + None
Incompatible 10 mg/ml + injectionMethylprednisolone sodium succinate 5 mg/ml + None
Compatible 10 mg/ml + injectionMetoclopramide hydrochloride 5 mg/ml + None
Compatible 10 mg/ml + injectionMidazolam hydrochloride 2 mg/ml + None
Incompatible 10 mg/ml + injectionMinocycline hydrochloride 0.2 mg/ml + None
Incompatible 10 mg/ml + injectionMitoxantrone dihydrochloride 0.5 mg/ml + None
Compatible 10 mg/ml + injectionMorphine sulfate 1 mg/ml + None
Compatible 10 mg/ml + injectionNafcillin sodium 20 mg/ml + None
Compatible 10 mg/ml + injectionNalbuphine hydrochloride 10 mg/ml + None
Compatible 10 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
Incompatible 10 mg/ml + injectionNetilmicin sulfate 5 mg/ml + None
Compatible 10 mg/ml + injectionNitroglycerin 0.4 mg/ml + None
Compatible 10 mg/ml + injectionNitroprusside sodium 0.4 mg/ml + None
Compatible 10 mg/ml + injectionNorepinephrine bitartrate 0.016 mg/ml + None
Compatible 10 mg/ml + injectionOfloxacin 4 mg/ml + None
Compatible 10 mg/ml + injectionPaclitaxel 1.2 mg/ml + None
Compatible 10 mg/ml + injectionPancuronium bromide 1 mg/ml + None
Compatible 10 mg/ml + injectionPentobarbital sodium 5 mg/ml + None
Compatible 10 mg/ml + injectionPethidine hydrochloride 4 mg/ml + None
Compatible 10 mg/ml + injectionPhenobarbital sodium 5 mg/ml + None
Compatible 10 mg/ml + injectionPhenylephrine hydrochloride 0.1 mg/ml + None
Incompatible 10 mg/ml + injectionPhenytoin sodium 50 mg/ml + None
Compatible 10 mg/ml + injectionPiperacillin sodium 40 mg/ml + None
Compatible 10 mg/ml + injectionPotassium chloride 100 mEq/l + None
Compatible 10 mg/ml + injectionProchlorperazine edysilate 0.5 mg/ml + None
Compatible 10 mg/ml + injectionPropranolol hydrochloride 1 mg/ml + None
Compatible 10 mg/ml + injectionRanitidine hydrochloride 2 mg/ml + None
Compatible 10 mg/ml + injectionScopolamine hydrobromide 0.4 mg/ml + None
Compatible 10 mg/ml + injectionSodium bicarbonate 84 mg/ml + None
Compatible 10 mg/ml + injectionSufentanil citrate 0.05 mg/ml + None
Compatible 10 mg/ml + injectionSuxamethonium chloride 20 mg/ml + None
Compatible 10 mg/ml + injectionTicarcillin / clavulanic acid 31 mg/ml + None
Incompatible 10 mg/ml + injectionTobramycin sulfate 5 mg/ml + None
Compatible 10 mg/ml + injectionVancomycin hydrochloride 10 mg/ml + None
Compatible 10 mg/ml + injectionVecuronium bromide 1 mg/ml + None
Compatible 10 mg/ml + injectionVerapamil hydrochloride 2.5 mg/ml + None
injectionPropranolol hydrochloride Beta-blocker
Compatible 1 mg/ml + injectionPropofol 10 mg/ml + None
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2 mg/ml + injectionPropofol 10 mg/ml + None
injectionScopolamine hydrobromide Antimuscarinic
Compatible 0.4 mg/ml + injectionPropofol 10 mg/ml + None
injectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + injectionPropofol 10 mg/ml + None
injectionSufentanil citrate Analgesic
Compatible 0.05 mg/ml + injectionPropofol 10 mg/ml + None
injectionSuxamethonium chloride Curarimimetic
Compatible 20 mg/ml + injectionPropofol 10 mg/ml + None
injectionTicarcillin / clavulanic acid Antibiotic
Compatible 31 mg/ml + injectionPropofol 10 mg/ml + None
injectionTobramycin sulfate Antibiotic
Incompatible 5 mg/ml + injectionPropofol 10 mg/ml + None
injectionVancomycin hydrochloride Antibiotic
Compatible 10 mg/ml + injectionPropofol 10 mg/ml + None
injectionVecuronium bromide Curarimimetic
Compatible 1 mg/ml + injectionPropofol 10 mg/ml + None
injectionVerapamil hydrochloride Anti-arrhythmic
Compatible 2.5 mg/ml + injectionPropofol 10 mg/ml + None

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