Last update :
09/04/2024
Anticancer drug   Methotrexate sodium  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Abitrexate Republic of South Africa
Antifolan Romania
Artrait Argentina
Bendatrexat Germany
Biometrox Brazil
Ebetrex Switzerland
Ebetrexate Austria
Emthexat Turkey
Emthexate Belgium, Netherlands, Republic of South Africa, Spain
Ledertrexate Belgium, France, Luxembourg, Morocco
Maxtrex Great Britain
Metex Germany, Norway
Methoblastin Republic of South Africa
Methotrexamed Germany
Methotrexate France
Metoject Chile, Denmark, Finland, France, Great Britain, Netherlands, Spain, Sweden, Switzerland
Metotrexato Chile
Trexan Finland
Trexat Germany
Compatibility   Injection   Compatibility : Methotrexate sodium              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Immediate precipitation Incompatible
Injection Methotrexate sodium 15 mg/ml
Parenteral nutrition (binary mixture) 301
Unspecified incompatibility Incompatible
Injection Methotrexate sodium
Injection Bleomycin sulfate
4154
Compatible
Injection Methotrexate sodium 15 mg/ml
Parenteral nutrition (with lipids) 1415
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Allopurinol sodium 3 mg/ml
Sodium chloride 0,9% 307
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Amifostine 10 mg/ml
Glucose 5% 3
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Amphotericin B cholesteryl sulfate complex 0.83 mg/ml
Glucose 5% 921
Compatible
Injection Methotrexate sodium 30 mg/ml
Injection Asparaginase 120 UI/ml
Sodium chloride 0,9% 150
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Aztreonam 40 mg/ml
Glucose 5% 99
Compatible
Injection Methotrexate sodium 0.4 mg/ml
Injection Cefalotin sodium 1 mg/ml
Glucose 5% 431
Compatible
Injection Methotrexate sodium 30 mg/ml
Injection Ceftriaxone disodium 100 mg/ml
Sodium chloride 0,9% 150
Unspecified incompatibility Incompatible
Injection Methotrexate sodium
Injection Chlorpromazine hydrochloride
3637
Compatible
Injection Methotrexate sodium 30 mg/ml
Injection Cyclophosphamide 20 mg/ml
Sodium chloride 0,9% 150
Unspecified incompatibility Incompatible
Injection Methotrexate sodium
Injection Cytarabine
3580
Chemical instability Incompatible
Injection Methotrexate sodium 0.2 mg/ml
Injection Cytarabine 0.4 mg/ml
Glucose 5% 431
Unspecified incompatibility Incompatible
Injection Methotrexate sodium
Injection Cytarabine
3637
Compatible
Injection Methotrexate sodium 30 mg/ml
Injection Cytarabine 0.6 mg/ml
Sodium chloride 0,9% 150
Precipitation after 1 hour Incompatible
Injection Methotrexate sodium
Injection Cytarabine
Ringer’s lactate solution 978
Compatible
Injection Methotrexate sodium 30 mg/ml
Injection Daunorubicin hydrochloride 0.52 mg/ml
Sodium chloride 0,9% 150
Color change after 4 hours Incompatible
Injection Methotrexate sodium 30 mg/ml
Injection Dexamethasone sodium phosphate 4 mg/ml
Sodium chloride 0,9% 150
Compatible
Injection Methotrexate sodium 12,5 mg/ml
Injection Doripenem 5 mg/ml
NaCl 0,9% or Glucose 5% 2262
Compatible
Injection Methotrexate sodium 25 mg/ml
Injection Doxorubicin hydrochloride 2 mg/ml
763
Compatible
Injection Methotrexate sodium 30 mg/ml
Injection Doxorubicin hydrochloride 0.4 mg/ml
Sodium chloride 0,9% 150
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Doxorubicin hydrochloride liposome peg 0.4 mg/ml
Glucose 5% 251
Immediate precipitation Incompatible
Injection Methotrexate sodium 25 mg/ml
Injection Droperidol 2.5 mg/ml
1088
Unspecified incompatibility Incompatible
Injection Methotrexate sodium
Injection Droperidol
3637
Immediate precipitation Incompatible
Injection Methotrexate sodium 25 mg/ml
Injection Droperidol 2,5 mg/ml
763
Compatible
Injection Methotrexate sodium 30 mg/ml
Injection Etoposide 0.6 mg/ml
Sodium chloride 0,9% 150
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Etoposide phosphate 5 mg/ml
Glucose 5% 1410
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Filgrastim 30 µg/ml
Glucose 5% 244
Unspecified incompatibility Incompatible
Injection Methotrexate sodium
Injection Fludarabine phosphate
3637
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Fludarabine phosphate 1 mg/ml
Glucose 5% 492
Compatible
Injection Methotrexate sodium 25 mg/ml
Injection Fluorouracil 50 mg/ml
763
Chemical instability Incompatible
Injection Methotrexate sodium 0.2 mg/ml
Injection Fluorouracil 0.25 mg/ml
Glucose 5% 431
Unspecified incompatibility Incompatible
Injection Methotrexate sodium
Injection Fluorouracil
3637
Unspecified incompatibility Incompatible
Injection Methotrexate sodium
Injection Fluorouracil
3474
Compatible
Injection Methotrexate sodium 30 mg/ml
Injection Folinate calcium 10 mg/ml
Sodium chloride 0,9% 150
Compatible
Injection Methotrexate sodium 25 mg/ml
Injection Folinate calcium 10 mg/ml
763
Compatible
Injection Methotrexate sodium 25 mg/ml
Injection Furosemide 10 mg/ml
763
Compatible
Injection Methotrexate sodium 25 mg/ml
Injection Furosemide 10 mg/ml
1088
Compatible
Injection Methotrexate sodium 25 mg/ml
Injection Gallium nitrate 1 mg/ml
Sodium chloride 0,9% 91
Immediate precipitation Incompatible
Injection Methotrexate sodium 15 mg/ml
Injection Gemcitabine hydrochloride 10 mg/ml
Sodium chloride 0,9% 1423
Compatible
Injection Methotrexate sodium 12.5 mg/ml
Injection Granisetron hydrochloride 1 mg/ml
Sodium chloride 0,9% 57
Unspecified incompatibility Incompatible
Injection Methotrexate sodium
Injection Heparin sodium
3637
Compatible
Injection Methotrexate sodium 25 mg/ml
Injection Heparin sodium 1000 UI/ml
763
Compatible
Injection Methotrexate sodium 30 mg/ml
Injection Heparin sodium 500 UI/ml
Sodium chloride 0,9% 150
Compatible
Injection Methotrexate sodium 1 & 3 mg/ml
Injection Hydroxyzine dihydrochloride 0.5 mg/ml
Glucose 5% 331
Unspecified incompatibility Incompatible
Injection Methotrexate sodium
Injection Idarubicin hydrochloride
3637
Color change Incompatible
Injection Methotrexate sodium 25 mg/ml
Injection Idarubicin hydrochloride 1 mg/ml
Sodium chloride 0,9% 491
Color change after 4 hours Incompatible
Injection Methotrexate sodium 30 mg/ml
Injection Ifosfamide 36 mg/ml
Sodium chloride 0,9% 150
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Linezolid 2 mg/ml
None 1925
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Melphalan 0.1 mg/ml
Sodium chloride 0,9% 169
Compatible
Injection Methotrexate sodium 30 mg/ml
Injection Mesna 1.8 mg/ml
Sodium chloride 0,9% 150
Compatible
Injection Methotrexate sodium 25 mg/ml
Injection Metoclopramide hydrochloride 5 mg/ml
763
Unspecified incompatibility Incompatible
Injection Methotrexate sodium
Injection Metoclopramide hydrochloride
3637
Immediate precipitation Incompatible
Injection Methotrexate sodium 30 mg/ml
Injection Midazolam hydrochloride 5 mg/ml
Sodium chloride 0,9% 150
Immediate precipitation Incompatible
Injection Methotrexate sodium 30 mg/ml
Injection Nalbuphine hydrochloride 10 mg/ml
Sodium chloride 0,9% 150
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Ondansetron hydrochloride 1 mg/ml
Sodium chloride 0,9% 334
Compatible
Injection Methotrexate sodium 0,5 mg/ml
Injection Ondansetron hydrochloride 0,03 mg/ml
Glucose 5% 184
Compatible
Injection Methotrexate sodium 0,5 mg/ml
Injection Ondansetron hydrochloride 0,3 mg/ml
Glucose 5% 184
Compatible
Injection Methotrexate sodium 6 mg/ml
Injection Ondansetron hydrochloride 0,3 mg/ml
Glucose 5% 184
Compatible
Injection Methotrexate sodium 6 mg/ml
Injection Ondansetron hydrochloride 0,03 mg/ml
Glucose 5% 184
Compatible
Injection Methotrexate sodium 30 mg/ml
Injection Ondansetron hydrochloride 2 mg/ml
Sodium chloride 0,9% 150
Compatible
Injection Methotrexate sodium 30 mg/ml
Injection Oxacillin sodium 250 mg/ml
Sodium chloride 0,9% 150
Compatible
Injection Methotrexate sodium 12,5 mg/ml
Injection Oxaliplatin 0,5 mg/ml
Glucose 5% 1662
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Paclitaxel 1.2 mg/ml
Glucose 5% 85
Precipitation after 2 hours Incompatible
Injection Methotrexate sodium 30 mg/ml
Injection Paracetamol 200 mg/ml
Sodium chloride 0,9% 150
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Piperacillin sodium / tazobactam 40/5 mg/ml
Glucose 5% 81
Unspecified incompatibility Incompatible
Injection Methotrexate sodium
Injection Promethazine hydrochloride
3637
Precipitation after 1 hour Incompatible
Injection Methotrexate sodium 15 mg/ml
Injection Propofol 10 mg/ml
None 300
Unspecified incompatibility Incompatible
Injection Methotrexate sodium
Injection Ranitidine hydrochloride
3637
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Sargramostim 10 µg/ml
Sodium chloride 0,9% 335
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Teniposide 0.1 mg/ml
Glucose 5% 905
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Thiotepa 1 mg/ml
Glucose 5% 249
Color change after 4 hours Incompatible
Injection Methotrexate sodium 30 mg/ml
Injection Vancomycin hydrochloride 5 mg/ml
Glucose 5% 150
Compatible
Injection Methotrexate sodium 25 mg/ml
Injection Vinblastine sulfate 1 mg/ml
763
Compatible
Injection Methotrexate sodium 0.008 mg/ml
Injection Vincristine sulfate 0.004 mg/ml
Glucose 5% 431
Compatible
Injection Methotrexate sodium 30 mg/ml
Injection Vincristine sulfate 0.1 mg/ml
Sodium chloride 0,9% 150
Compatible
Injection Methotrexate sodium 25 mg/ml
Injection Vincristine sulfate 1 mg/ml
763
Compatible
Injection Methotrexate sodium 30 mg/ml
Injection Vindesine sulfate 0.1 mg/ml
Sodium chloride 0,9% 150
Compatible
Injection Methotrexate sodium 15 mg/ml
Injection Vinorelbine tartrate 1 mg/ml
Sodium chloride 0,9% 84

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