Last update :
11/08/2022
Glucose-lowering   Insulin  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Actrapid Texte introuvable (616, ), Austria, Belgium, Croatia, Denmark, Finland, France, Great Britain, Greece, Hungary, Ireland, Italy, Netherlands, Norway, Poland, Portugal, Republic of South Africa, Russian, Serbia, Slovenia, Spain, Sweden, Switzerland, Turkey
Biosulin Russian
Gensulin Poland
Humaject Croatia, Poland, Slovenia
Humaplus Spain
Humasulin Austria, Switzerland
Humasulina Spain
Humulin R Texte introuvable (616, ), Canada, Croatia, Denmark, Great Britain, Greece, Poland, Republic of South Africa, Slovenia, Turkey, United States of America
Humuline Belgium, Netherlands
Insuman Texte introuvable (616, ), Austria, Denmark, Finland, France, Great Britain, Ireland, Netherlands, Norway, Russian, Sweden, Switzerland
Isuhuman Portugal
Novolin Canada
Umuline France
Velosulin Texte introuvable (616, ), Austria, Belgium, France
Velosuline United States of America
Compatibility   Injection   Compatibility : Insulin              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Immediate turbidity Incompatible
Injection Insulin 1 UI/ml
Injection Alprostadil 20 µg/ml
Glucose 5% 4491
Immediate precipitation Incompatible
Injection Insulin 1 UI/ml
Injection Alprostadil 20 µg/ml
Sodium chloride 0,9% 4651
Compatible
Injection Insulin 1 UI/ml
Injection Amiodarone hydrochloride 0,6 >> 9,75 mg/ml
Glucose 5% 4119
Compatible
Injection Insulin 2 UI/ml
Injection Amiodarone hydrochloride 15 mg/ml
NaCl 0,9% or Glucose 5% 3823
Compatible
Injection Insulin 1 UI/ml
Injection Amiodarone hydrochloride 4.8 mg/ml
Glucose 5% 295
Compatible
Injection Insulin
Injection Amiodarone hydrochloride
3464
Immediate turbidity Incompatible
Injection Insulin 1 UI/ml
Injection Amiodarone hydrochloride 25 mg/ml
Glucose 5% 4119
Compatible
Injection Insulin 1 UI/ml
Injection Amiodarone hydrochloride 12,5 mg/ml
Glucose 5% 4119
Compatible
Injection Insulin 1 UI/ml
Injection Amoxicillin sodium 20.83 & 83.3 mg/ml
Sodium chloride 0,9% 4254
Compatible
Injection Insulin 0.2 UI/ml
Injection Ampicillin sodium 20 mg/ml
Sodium chloride 0,9% 129
Compatible
Injection Insulin 0.2 UI/ml
Injection Ampicillin sodium - sulbactam sodium 30 mg/ml
Sodium chloride 0,9% 129
Compatible
Injection Insulin 0.2 UI/ml
Injection Aztreonam 20 mg/ml
Sodium chloride 0,9% 129
Compatible
Injection Insulin 1 UI/ml
Injection Bretylium tosilate 1 mg/ml
NaCl 0,9% or Glucose 5% 1193
Compatible
Injection Insulin 100 UI/ml
Injection Caffeine 10 mg/ml
None 3964
Compatible
Injection Insulin 1 UI/ml
Injection Caspofungin acetate 0,7 mg/ml
Sodium chloride 0,9% 2247
Compatible
Injection Insulin 1 UI/ml
Injection Caspofungin acetate 0.5 mg/ml
Sodium chloride 0,9% 2233
Compatible
Injection Insulin 0.2 UI/ml
Injection Cefazolin sodium 20 mg/ml
Sodium chloride 0,9% 129
Compatible
Injection Insulin 100 UI/ml
Injection Cefepime dihydrochloride 125 mg/ml
Water for Injection 2141
Compatible
Injection Insulin 1 UI/ml
Injection Cefiderocol sulfate tosylate 20 mg/mL
NaCl 0,9% or Glucose 5% 4528
Compatible
Injection Insulin 1 UI/ml
Injection Cefotaxime sodium 83.3 mg/ml
NaCl 0,9% or Glucose 5% 4254
Compatible
Injection Insulin 1 UI/ml
Injection Ceftaroline fosamil 2,22 mg/ml
NaCl 0,9% or Glucose 5% 3249
Compatible
Injection Insulin 1 UI/ml
Injection Ceftaroline fosamil 2,22 mg/ml
Ringer’s lactate solution 3249
Compatible
Injection Insulin 100 UI/ml
Injection Ceftazidime 125 mg/ml
Water for Injection 2141
Unspecified incompatibility Incompatible
Injection Insulin
Injection Ceftobiprole medocaril sodium
4650
Immediate turbidity Incompatible
Injection Insulin 1 UI/ml
Injection Ceftobiprole medocaril sodium 2 mg/ml
Ringer’s lactate solution 2269
Immediate turbidity Incompatible
Injection Insulin 1 UI/ml
Injection Ceftobiprole medocaril sodium 2 mg/ml
NaCl 0,9% or Glucose 5% 2269
Compatible
Injection Insulin 1 UI/ml
Injection Ceftolozane / tazobactam 10/5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
Injection Insulin 0.1 UI/ml
Injection Cimetidine hydrochloride 1.2 & 5 mg/ml
NaCl 0,9% or Glucose 5% 1201
Compatible
Injection Insulin 1 UI/ml
Injection Cisatracurium besylate 1 mg/ml
Sodium chloride 0,9% 3429
Compatible
Injection Insulin 2 UI/ml
Injection Cisatracurium besylate 5 mg/ml
Sodium chloride 0,9% 3823
Compatible
Injection Insulin 1 UI/ml
Injection Clonidine hydrochloride 0.0075 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
Injection Insulin 100 UI/ml
Injection Cloxacillin sodium 100 mg/ml
Water for Injection 3012
Turbidity in one hour Incompatible
Injection Insulin 1 UI/ml
Injection Co-trimoxazole 3.2/0.64 & 80/16 mg/ml
NaCl 0,9% or Glucose 5% 4254
Unspecified incompatibility Incompatible
Injection Insulin
Injection Cytarabine
3580
Compatible
Injection Insulin 2 UI/ml
Injection Diclofenac 3 mg/ml
Sodium chloride 0,9% 3823
Immediate precipitation Incompatible
Injection Insulin 100 UI/ml
Injection Diltiazem hydrochloride 1 & 5 mg/ml
Sodium chloride 0,9% 198
Compatible
Injection Insulin 0.4 UI/ml
Injection Diltiazem hydrochloride 5 mg/ml
Sodium chloride 0,9% 198
Color change after 24 hours Incompatible
Injection Insulin 1 UI/ml
Injection Dobutamine hydrochloride 1 mg/ml
NaCl 0,9% or Glucose 5% 1058
Immediate precipitation Incompatible
Injection Insulin 100 UI/ml
Injection Dobutamine hydrochloride 2 mg/ml
Glucose 5% 1041
Compatible
Injection Insulin 1 UI/ml
Injection Dobutamine hydrochloride 8 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
Injection Insulin 1 UI/ml
Injection Dopamine hydrochloride 8 mg/ml
NaCl 0,9% or Glucose 5% 1506
Immediate precipitation Incompatible
Injection Insulin 100 UI/ml
Injection Dopamine hydrochloride 3,2 mg/ml
4389
Immediate precipitation Incompatible
Injection Insulin 1 UI/ml
Injection Dopamine hydrochloride 3.2 mg/ml
Glucose 5% 295
Compatible
Injection Insulin 1 UI/ml
Injection Doripenem 5 mg/ml
NaCl 0,9% or Glucose 5% 2262
Compatible
Injection Insulin 1 UI/ml
Injection Doxapram hydrochloride 2 mg/ml
Glucose 5% 1802
Compatible
Injection Insulin 1 UI/ml
Injection Eravacycline 0,6 mg/ml
Sodium chloride 0,9% 4434
Compatible
Injection Insulin 1 UI/ml
Injection Esmolol hydrochloride 40 mg/ml
Glucose 5% 295
Compatible
Injection Insulin 1 UI/ml
Injection Esomeprazole sodium 0.32 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
Injection Insulin 0.03 UI/ml
Injection Famotidine 0.2 mg/ml
Glucose 5% 398
Compatible
Injection Insulin 1 UI/ml
Injection Fosfomycin 30 mg/ml
NaCl 0,9% or Glucose 5% 4055
Compatible
Injection Insulin 2 UI/ml
Injection Furosemide 10 mg/ml
Sodium chloride 0,9% 3823
Compatible
Injection Insulin 2 UI/ml
Injection Furosemide 10 mg/ml
None 3134
Compatible
Injection Insulin 1 UI/ml
Injection Furosemide 10 mg/ml
None 3210
Compatible
Injection Insulin
Injection Furosemide
3465
Compatible
Injection Insulin 0.2 UI/ml
Injection Gentamicin sulfate 1.2 >> 2 mg/ml
Sodium chloride 0,9% 129
Compatible
Injection Insulin 1 UI/ml
Injection Glycerophosphate disodium
4332
Compatible
Injection Insulin 2 UI/ml
Injection Haloperidol lactate 0.5 mg/ml
Sodium chloride 0,9% 3823
Compatible
Injection Insulin 0.2 UI/ml
Injection Heparin sodium 60 UI/ml
Sodium chloride 0,9% 129
Compatible
Injection Insulin 2 UI/ml
Injection Heparin sodium 500 UI/ml
Sodium chloride 0,9% 3823
Compatible
Injection Insulin 1 UI/ml
Injection Ibuprofen lysinate 10 mg/ml
Water for Injection 4419
Compatible
Injection Insulin 0.1 UI/ml
Injection Ibuprofen lysinate 10 mg/ml
Water for Injection 4419
Compatible
Injection Insulin 1 UI/ml
Injection Imipenem-Cilastatin / Relebactam 5 mg/ml
Sodium chloride 0,9% 4433
Compatible
Injection Insulin 1 UI/ml
Injection Indomethacin sodium trihydrate 1 mg/ml
Sodium chloride 0,9% 467
Compatible
Injection Insulin 1 UI/ml
Injection Isavuconazonium sulfate 1.5 mg/ml
NaCl 0,9% or Glucose 5% 3829
Immediate precipitation Incompatible
Injection Insulin 100 UI/ml
Injection Ketamine hydrochloride 50 mg/ml
2109
Immediate precipitation Incompatible
Injection Insulin 1 UI/ml
Injection Labetalol hydrochloride 5 mg/ml
Glucose 5% 295
Immediate precipitation Incompatible
Injection Insulin 100 UI/ml
Injection Levofloxacine 5 mg/ml
Glucose 5% 1072
Immediate precipitation Incompatible
Injection Insulin 1 UI/ml
Injection Levofloxacine 5 mg/ml
Glucose 5% 1072
Compatible
Injection Insulin 1 UI/ml
Injection Lidocaine hydrochloride 2 mg/ml
Ringer’s lactate solution 619
Compatible
Injection Insulin 1 UI/ml
Injection Lidocaine hydrochloride 2 mg/ml
NaCl 0,9% or Glucose 5% 619
Compatible
Injection Insulin 1 UI/ml
Injection Linezolid 2 mg/ml
Sodium chloride 0,9% 4254
Compatible
Injection Insulin 0.2 UI/ml
Injection Magnesium sulfate 40 mg/ml
Sodium chloride 0,9% 129
Compatible
Injection Insulin 100 UI/ml
Injection Meropenem 50 mg/ml
Water for Injection 4319
Compatible
Injection Insulin 1 UI/ml
Injection Meropenem 1 & 20 mg/ml
Sodium chloride 0,9% 266
Compatible
Injection Insulin 0.2 UI/ml
Injection Meropenem 1 & 50 mg/ml
Sodium chloride 0,9% 266
Compatible
Injection Insulin 1 UI/ml
Injection Methadone hydrochloride 0.2 mg/ml
NaCl 0,9% or Glucose 5% 1506
Precipitation after 4 hours Incompatible
Injection Insulin 1 UI/ml
Injection Micafungin 1.5 mg/ml
Sodium chloride 0,9% 2108
Compatible
Injection Insulin 1 UI/ml
Injection Midazolam hydrochloride 1 mg/ml
Glucose 5% 295
Compatible
Injection Insulin 2 UI/ml
Injection Midazolam hydrochloride 2.1 mg/ml
Sodium chloride 0,9% 3823
Compatible
Injection Insulin 1 UI/ml
Injection Midazolam hydrochloride 4 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
Injection Insulin 2 UI/ml
Injection Milrinone lactate 0.8 mg/ml
Glucose 5% 813
Compatible
Injection Insulin 0.2 UI/ml
Injection Morphine sulfate 5 mg/ml
Sodium chloride 0,9% 129
Compatible
Injection Insulin 1 UI/ml
Injection Morphine sulfate 1 mg/ml
Glucose 5% 295
Compatible
Injection Insulin 0.2 UI/ml
Injection Morphine sulfate 1 mg/ml
Sodium chloride 0,9% 406
Unspecified incompatibility Incompatible
Injection Insulin 100 UI/ml
Injection N-acetylcysteine 200 mg/ml
None 3766
Immediate precipitation Incompatible
Injection Insulin 0.2 UI/ml
Injection Nafcillin sodium 20 & 40 mg/ml
Sodium chloride 0,9% 129
Compatible
Injection Insulin 100 UI/ml
Injection Naloxone hydrochloride 0.4 mg/ml
None 3408
Compatible
Injection Insulin 2 UI/ml
Injection Nitroglycerin 0.2 mg/ml
NaCl 0,9% or Glucose 5% 3823
Compatible
Injection Insulin 1 UI/ml
Injection Nitroglycerin 0.2 mg/ml
Glucose 5% 295
Compatible
Injection Insulin 1 UI/ml
Injection Nitroprusside sodium 0.2 mg/ml
Glucose 5% 295
Compatible
Injection Insulin 1 UI/ml
Injection Norepinephrine bitartrate 0.32 mg/ml
NaCl 0,9% or Glucose 5% 1506
Immediate precipitation Incompatible
Injection Insulin 1 UI/ml
Injection Norepinephrine bitartrate 0.064 mg/ml
Glucose 5% 295
Compatible
Injection Insulin 1 UI/ml
Injection Oritavancin 0.8 >>2 mg/ml
Glucose 5% 3152
Compatible
Injection Insulin 1 UI/ml
Injection Ornidazole 31.25 mg/ml
Sodium chloride 0,9% 4254
Compatible
Injection Insulin 0.2 UI/ml
Injection Oxytocin 0.02 UI/ml
Sodium chloride 0,9% 129
Precipitation after 1 hour Incompatible
Injection Insulin
Injection Pantoprazole sodium
2090
Compatible
Injection Insulin 5 >> 50 UI/ml
Injection Pantoprazole sodium 0.16 >> 0.8 mg/ml
Sodium chloride 0,9% 1902
Compatible
Injection Insulin 0,2 UI/ml
Injection Pentoxifyllin 5 mg/ml
Sodium chloride 0,9% 4543
Compatible
Injection Insulin 0.2 UI/ml
Injection Pethidine hydrochloride 10 mg/ml
Sodium chloride 0,9% 406
Compatible
Injection Insulin 0.2 UI/ml
Injection Pethidine hydrochloride 50 mg/ml
Sodium chloride 0,9% 129
Compatible
Injection Insulin 1 UI/ml
Injection Piperacillin sodium / tazobactam 166/20.83 mg/ml
NaCl 0,9% or Glucose 5% 4254
Compatible
Injection Insulin 1 UI/ml
Injection Plazomicin sulfate 24 mg/ml
Sodium chloride 0,9% 4145
Compatible
Injection Insulin 40 UI/ml
Injection Potassium chloride 40 mEq/l
Ringer’s lactate solution 730
Compatible
Injection Insulin 40 UI/ml
Injection Potassium chloride 40 mEq/l
NaCl 0,9% or Glucose 5% 730
Compatible
Injection Insulin
Injection Potassium phosphate
3781
Compatible
Injection Insulin 1 UI/ml
Injection Propofol 10 mg/ml
None 300
Compatible
Injection Insulin 1 UI/ml
Injection Remifentanil hydrochloride 120 µg/ml
Glucose 5% 3176
Unspecified incompatibility Incompatible
Injection Insulin
Injection Rocuronium bromide
3564
Immediate precipitation Incompatible
Injection Insulin 100 UI/ml
Injection Salbutamol sulfate 1 mg/ml
None 3216
Compatible
Injection Insulin 2 UI/ml
Injection Sodium bicarbonate 84 mg/ml
None 3212
Compatible
Injection Insulin
Injection Sodium bicarbonate
3466
Compatible
Injection Insulin 2 UI/ml
Injection Sodium bicarbonate 84 mg/ml
Sodium chloride 0,9% 3823
Compatible
Injection Insulin 100 UI/ml
Injection Sugammadex 100 mg/ml
None 3372
Compatible
Injection Insulin 0,1 UI/ml
Injection Tacrolimus 1000 µg/ml
Sodium chloride 0,9% 479
Compatible
Injection Insulin 1 UI/ml
Injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3827
Compatible
Injection Insulin 100 UI/ml
Injection Temocilline 83.33 mg/ml
Water for Injection 2231
Compatible
Injection Insulin 0.2 UI/ml
Injection Terbutaline sulfate 0.02 mg/ml
Sodium chloride 0,9% 129
Compatible
Injection Insulin
Injection Thiopental sodium 25 mg/ml
Sodium chloride 0,9% 3767
Compatible
Injection Insulin 0.2 UI/ml
Injection Ticarcillin / clavulanic acid 31 mg/ml
Sodium chloride 0,9% 129
Compatible
Injection Insulin 2 UI/ml
Parenteral nutrition (binary mixture) 939
Compatible
Injection Insulin 2 UI/ml
Injection Tirofiban 250 µg/ml
Sodium chloride 0,9% 3823
Compatible
Injection Insulin 0.2 UI/ml
Injection Tobramycin sulfate 1.6 & 2 mg/ml
Sodium chloride 0,9% 129
Compatible
Injection Insulin 2 UI/ml
Injection Urapidil 5 mg/ml
Sodium chloride 0,9% 3823
Compatible
Injection Insulin 0.2 UI/ml
Injection Vancomycin hydrochloride 4 mg/ml
Sodium chloride 0,9% 129
Chemical instability Incompatible
Injection Insulin
Parenteral nutrition (with lipids) 4567
Compatible
Injection Insulin 1 UI/ml
Parenteral nutrition (with lipids) 1415
Compatible
Injection Insulin 100 UI/ml
Ringer’s lactate solution 4603
Compatible
Injection Insulin 100 UI/ml
Injection Vancomycin hydrochloride 10 mg/ml
Glucose 5% 3385
Compatible
Injection Insulin 1 UI/ml
Injection Vasopressin 0.2 UI/ml
Sodium chloride 0,9% 2017
Compatible
Injection Insulin 0,2 UI/ml
Injection Verapamil hydrochloride 0,08 mg/ml
Sodium chloride 0,9% 706
Compatible
Injection Insulin 1 UI/ml
Parenteral nutrition (binary mixture) 301

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