Last update :
24/05/2022
References   References 4650  
Type : Manufacturer

Research teams :
Authors :
Title : Ceftobiprole (Zevtera 500 mg powder for concentrate for solution for infusion.) Summary of Product Characteristics, Advanz Pharma updated 4 aug 2021.
Reference : Advanz Pharma 2021

Level of Evidence : 
Manufacturer's stability data
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionAciclovir sodium Antiviral
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionAmikacin sulfate Antibiotic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionAmiodarone hydrochloride Anti-arrhythmic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionAmphotericin B Antifungal
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionCalcium gluconate Electrolyte
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionCaspofungin acetate Antifungal
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionCeftobiprole medocaril sodium Antibiotic
Factors which affect stability Storage Light Induces Degradation
Stability in solutions Glass Water for Injection 50 mg/ml 2-8°C Not specified
24 Hour
Stability in solutions Glass Water for Injection 50 mg/ml 25°C Not specified
1 Hour
Stability in solutions Glass Sodium chloride 0,9% 2,67 mg/ml 2-8°C Protect from light
4 Day
Stability in solutions Glass Sodium chloride 0,9% 2,67 mg/ml 25°C Protect from light
24 Hour
Stability in solutions Glass Sodium chloride 0,9% 2,67 mg/ml 25°C Light
8 Hour
Stability in solutions Glass Glucose 5% 2,67 mg/ml 2-8°C Protect from light
4 Day
Stability in solutions Glass Glucose 5% 2,67 mg/ml 25°C Protect from light
12 Hour
Stability in solutions Glass Glucose 5% 2,67 mg/ml 25°C Light
8 Hour
Stability in solutions Glass Glucose 5% 50 mg/ml 2-8°C Not specified
24 Hour
Stability in solutions Glass Glucose 5% 50 mg/ml 25°C Not specified
1 Hour
Stability in solutions Glass Ringer’s lactate solution 2,67 mg/ml 25°C Protect from light
24 Hour
Stability in solutions Glass Ringer’s lactate solution 2,67 mg/ml 25°C Light
8 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 2,67 mg/ml 2-8°C Protect from light
4 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 2,67 mg/ml 25°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 2,67 mg/ml 25°C Light
8 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 2,67 mg/ml 2-8°C Protect from light
4 Day
Stability in solutions Polyvinyl chloride Glucose 5% 2,67 mg/ml 25°C Protect from light
12 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 2,67 mg/ml 25°C Light
8 Hour
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 2,67 mg/ml 25°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 2,67 mg/ml 25°C Light
8 Hour
Stability in solutions Polyethylene Sodium chloride 0,9% 2,67 mg/ml 2-8°C Protect from light
4 Day
Stability in solutions Polyethylene Sodium chloride 0,9% 2,67 mg/ml 25°C Protect from light
24 Hour
Stability in solutions Polyethylene Sodium chloride 0,9% 2,67 mg/ml 25°C Light
8 Hour
Stability in solutions Polyethylene Glucose 5% 2,67 mg/ml 2-8°C Protect from light
4 Day
Stability in solutions Polyethylene Glucose 5% 2,67 mg/ml 25°C Protect from light
12 Hour
Stability in solutions Polyethylene Glucose 5% 2,67 mg/ml 25°C Light
8 Hour
Stability in solutions Polyethylene Ringer’s lactate solution 2,67 mg/ml 25°C Protect from light
24 Hour
Stability in solutions Polyethylene Ringer’s lactate solution 2,67 mg/ml 25°C Light
8 Hour
Incompatible + InjectionAciclovir sodium
Incompatible + InjectionAmikacin sulfate
Incompatible + InjectionAmiodarone hydrochloride
Incompatible + InjectionAmphotericin B
Incompatible + InjectionCalcium gluconate
Incompatible + InjectionCaspofungin acetate
Incompatible + InjectionCiprofloxacin lactate
Incompatible + InjectionCisatracurium besylate
Incompatible + InjectionDiazepam
Incompatible + InjectionDiltiazem hydrochloride
Incompatible + InjectionDiphenhydramine hydrochloride
Incompatible + InjectionDobutamine hydrochloride
Incompatible + InjectionDopamine hydrochloride
Incompatible + InjectionEsomeprazole sodium
Incompatible + InjectionFamotidine
Incompatible + InjectionFilgrastim
Incompatible + InjectionGentamicin sulfate
Incompatible + InjectionHaloperidol lactate
Incompatible + InjectionHydromorphone hydrochloride
Incompatible + InjectionHydroxyzine dihydrochloride
Incompatible + InjectionInsulin
Incompatible + InjectionInsulin lyspro
Incompatible + InjectionLabetalol hydrochloride
Incompatible + InjectionLevofloxacine
Incompatible + InjectionLidocaine hydrochloride
Incompatible + InjectionMagnesium sulfate
Incompatible + InjectionMetoclopramide hydrochloride
Incompatible + InjectionMidazolam hydrochloride
Incompatible + InjectionMilrinone lactate
Incompatible + InjectionMorphine sulfate
Incompatible + InjectionMoxifloxacin
Incompatible + InjectionOndansetron hydrochloride
Incompatible + InjectionPantoprazole sodium
Incompatible + InjectionPethidine hydrochloride
Incompatible + InjectionPotassium phosphate
Incompatible + InjectionPromethazine hydrochloride
Incompatible + InjectionRemifentanil hydrochloride
Incompatible + InjectionSodium Phosphate
Incompatible + InjectionTobramycin sulfate
InjectionCiprofloxacin lactate Antibiotic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionCisatracurium besylate Curarimimetic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionDiazepam Anxiolytic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionDiltiazem hydrochloride Anti-arrhythmic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionDobutamine hydrochloride Cardiotonic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionDopamine hydrochloride Cardiotonic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionEsomeprazole sodium Proton pump inhibitor
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionFamotidine Antihistamine (H2)
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionFilgrastim Various
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionGentamicin sulfate Antibiotic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionHaloperidol lactate Neuroleptic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionHydromorphone hydrochloride Analgesic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionHydroxyzine dihydrochloride Anxiolytic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionInsulin Glucose-lowering
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionInsulin lyspro Glucose-lowering
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionLabetalol hydrochloride Beta-blocker
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionLevofloxacine Antibiotic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionLidocaine hydrochloride Local anesthetic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionMagnesium sulfate Electrolyte
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionMetoclopramide hydrochloride Antiemetic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionMidazolam hydrochloride Anxiolytic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionMilrinone lactate Cardiotonic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionMorphine sulfate Analgesic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionMoxifloxacin Antibiotic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionOndansetron hydrochloride Antiemetic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionPantoprazole sodium Proton pump inhibitor
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionPethidine hydrochloride Analgesic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionPotassium phosphate Electrolyte
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionPromethazine hydrochloride Antihistamine (H1)
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionRemifentanil hydrochloride Analgesic
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionSodium Phosphate Electrolyte
Incompatible + InjectionCeftobiprole medocaril sodium
InjectionTobramycin sulfate Antibiotic
Incompatible + InjectionCeftobiprole medocaril sodium

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