Last update :
19/09/2022
References   References 4698  
Type : Journal

Research teams : Nancy - University Hospital of Nancy, Department of Pharmacy
Authors : Ayari G, D'Huart E, Vigneron J, Demoré B.
Title : Y-site compatibility of intravenous medications commonly used in intensive care units : laboratory tests on 75 mixtures involving nine main drugs.
Reference : Pharmaceutical Technology in Hospital Pharmacy 2022

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
InjectionAcetylsalicylic acid lysinate Analgesic
Compatible 10 mg/ml + InjectionHydrocortisone sodium succinate 2 mg/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + InjectionInsulin 1 UI/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + InjectionMagnesium sulfate 6 mg/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + InjectionNefopam 0,08 mg/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + InjectionPhytomenadione 0,2 mg/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + InjectionPotassium chloride 1340 mEq/l + Sodium chloride 0,9%
Compatible 10 mg/ml + InjectionThiamine hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionAmiodarone hydrochloride Anti-arrhythmic
Compatible 3 mg/ml + InjectionBumetanide 0,2 mg/ml + Glucose 5%
Incompatible 3 mg/ml + InjectionCefazolin sodium 40 mg/ml + Glucose 5%
Compatible 9 mg/ml + InjectionCefotaxime sodium 40 mg/ml + Glucose 5%
Incompatible 18 mg/ml + InjectionFurosemide 5 mg/ml + Glucose 5%
Compatible 9 mg/ml + InjectionHydrocortisone sodium succinate 2 mg/ml + Glucose 5%
Compatible 6 mg/ml + InjectionInsulin 1 UI/ml + Glucose 5%
Compatible 3 mg/ml + InjectionLevofloxacine 5 mg/ml + Glucose 5%
Compatible 9 mg/ml + InjectionMagnesium sulfate 1,5 mg/ml + Glucose 5%
Compatible 9 mg/ml + InjectionNefopam 0,16 mg/ml + Glucose 5%
Compatible 18 mg/ml + InjectionParacetamol 10 mg/ml + Glucose 5%
Compatible 3 mg/ml + InjectionPotassium chloride 1340 mEq/l + Glucose 5%
Compatible 3 mg/ml + InjectionThiamine hydrochloride 2 mg/ml + Glucose 5%
Compatible 9 mg/ml + InjectionVancomycin hydrochloride 31,3 mg/ml + Glucose 5%
InjectionAtenolol Beta-blocker
Incompatible 0,1 mg/ml + InjectionCiclosporin 10 mg/ml + Sodium chloride 0,9%
Compatible 0,1 mg/ml + InjectionMethylprednisolone sodium succinate 0,2 mg/ml + Sodium chloride 0,9%
Incompatible 0,1 mg/ml + InjectionMetronidazole 5 mg/ml + Sodium chloride 0,9%
Incompatible 0,1 mg/ml + InjectionMycophenolate mofetil 10 mg/ml + Sodium chloride 0,9%
Compatible 0,1 mg/ml + InjectionThiamine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 0,1 mg/ml + InjectionUrapidil 5 mg/ml + Sodium chloride 0,9%
InjectionBumetanide Diuretic
Compatible 0,2 mg/ml + InjectionAmiodarone hydrochloride 3 mg/ml + Glucose 5%
InjectionCalcium chloride Electrolyte
Compatible 2 mg/ml + InjectionNefopam 0,8 mg/ml + Sodium chloride 0,9%
InjectionCefazolin sodium Antibiotic
Incompatible 40 mg/ml + InjectionAmiodarone hydrochloride 3 mg/ml + Glucose 5%
InjectionCefotaxime sodium Antibiotic
Compatible 40 mg/ml + InjectionAmiodarone hydrochloride 9 mg/ml + Glucose 5%
Incompatible 40 mg/ml + InjectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
InjectionCiclosporin Immunosuppressant
Incompatible 10 mg/ml + InjectionAtenolol 0,1 mg/ml + Sodium chloride 0,9%
InjectionClonidine hydrochloride Antihypertensive
Incompatible 0,0125 mg/ml + InjectionMethylprednisolone sodium succinate 0,2 mg/ml + Sodium chloride 0,9%
Compatible 0,0125 mg/ml + InjectionMycophenolate mofetil 10 mg/ml + Sodium chloride 0,9%
Compatible 0,0125 mg/ml + InjectionThiamine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 0,0125 mg/ml + InjectionUrapidil 5 mg/ml + Sodium chloride 0,9%
InjectionFurosemide Diuretic
Incompatible 5 mg/ml + InjectionAmiodarone hydrochloride 18 mg/ml + Glucose 5%
Incompatible 10 mg/ml + InjectionMagnesium sulfate 6 mg/ml
Incompatible 10 mg/ml + InjectionNefopam 1,7 mg/ml
Compatible 10 mg/ml + InjectionParacetamol 10 mg/ml
Incompatible 10 mg/ml + InjectionSpiramycine adipate 60 MUI/ml
InjectionHeparin sodium Anticoagulant
Incompatible 208,3 UI/ml + InjectionLevetiracetam 15 mg/ml + Sodium chloride 0,9%
Incompatible 208,3 UI/ml + InjectionMidazolam hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 208,3 UI/ml + InjectionNefopam 1,7 mg/ml + Sodium chloride 0,9%
Compatible 208,3 UI/ml + InjectionParacetamol 10 mg/ml + Sodium chloride 0,9%
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 2 mg/ml + InjectionAcetylsalicylic acid lysinate 10 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionAmiodarone hydrochloride 9 mg/ml + Glucose 5%
Compatible 2 mg/ml + InjectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
InjectionInsulin Glucose-lowering
Compatible 1 UI/ml + InjectionAcetylsalicylic acid lysinate 10 mg/ml + Sodium chloride 0,9%
Compatible 1 UI/ml + InjectionAmiodarone hydrochloride 6 mg/ml + Glucose 5%
Compatible 1 UI/ml + InjectionIsosorbide dinitrate 1 mg/ml + Sodium chloride 0,9%
Compatible 1 UI/ml + InjectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
Incompatible 1 UI/ml + InjectionPantoprazole sodium 1 mg/ml + Sodium chloride 0,9%
Compatible 1 UI/ml + InjectionParacetamol 10 mg/ml + Sodium chloride 0,9%
Compatible 1 UI/ml + InjectionPhloroglucinol 10 mg/ml + Sodium chloride 0,9%
Incompatible 1 UI/ml + InjectionRemifentanil hydrochloride 100 µg/ml + Sodium chloride 0,9%
InjectionIsosorbide dinitrate Vasodilator
Compatible 1 mg/ml + InjectionInsulin 1 UI/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
InjectionLevetiracetam Antiepileptic
Incompatible 15 mg/ml + InjectionHeparin sodium 208,3 UI/ml + Sodium chloride 0,9%
InjectionLevofloxacine Antibiotic
Compatible 5 mg/ml + InjectionAmiodarone hydrochloride 3 mg/ml + Glucose 5%
InjectionMagnesium sulfate Electrolyte
Compatible 6 mg/ml + InjectionAcetylsalicylic acid lysinate 10 mg/ml + Sodium chloride 0,9%
Compatible 1,5 mg/ml + InjectionAmiodarone hydrochloride 9 mg/ml + Glucose 5%
Incompatible 6 mg/ml + InjectionFurosemide 10 mg/ml
Compatible 3>>4,5 mg/ml + InjectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 0,2 mg/ml + InjectionAtenolol 0,1 mg/ml + Sodium chloride 0,9%
Incompatible 0,2 mg/ml + InjectionClonidine hydrochloride 0,0125 mg/ml + Sodium chloride 0,9%
InjectionMetronidazole Antiparasitic
Incompatible 5 mg/ml + InjectionAtenolol 0,1 mg/ml + Sodium chloride 0,9%
InjectionMidazolam hydrochloride Anxiolytic
Incompatible 1 mg/ml + InjectionHeparin sodium 208,3 UI/ml + Sodium chloride 0,9%
InjectionMycophenolate mofetil Immunosuppressant
Incompatible 10 mg/ml + InjectionAtenolol 0,1 mg/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + InjectionClonidine hydrochloride 0,0125 mg/ml + Sodium chloride 0,9%
InjectionNefopam Analgesic
Compatible 0,08 mg/ml + InjectionAcetylsalicylic acid lysinate 10 mg/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + InjectionAmiodarone hydrochloride 9 mg/ml + Glucose 5%
Compatible 0,8 mg/ml + InjectionCalcium chloride 2 mg/ml + Sodium chloride 0,9%
Incompatible 0,16 mg/ml + InjectionCefotaxime sodium 40 mg/ml + Sodium chloride 0,9%
Incompatible 1,7 mg/ml + InjectionFurosemide 10 mg/ml
Incompatible 1,7 mg/ml + InjectionHeparin sodium 208,3 UI/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + InjectionHydrocortisone sodium succinate 2 mg/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + InjectionInsulin 1 UI/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + InjectionIsosorbide dinitrate 1 mg/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + InjectionMagnesium sulfate 3>>4,5 mg/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + InjectionNicardipine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + InjectionPyridoxine hydrochloride 0,5 mg/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + InjectionThiamine hydrochloride 0,5 mg/ml + Sodium chloride 0,9%
Compatible 0,16 mg/ml + InjectionTramadol hydrochloride 6,3 mg/ml + Sodium chloride 0,9%
InjectionNicardipine hydrochloride Vasodilator
Compatible 1 mg/ml + InjectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
InjectionPantoprazole sodium Proton pump inhibitor
Incompatible 1 mg/ml + InjectionInsulin 1 UI/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + InjectionParacetamol 10 mg/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + InjectionPhloroglucinol 0,4 mg/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + InjectionPhytomenadione 0,2 mg/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + InjectionPyridoxine hydrochloride 0,0025 mg/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + InjectionThiamine hydrochloride 1 mg/ml + Sodium chloride 0,9%
InjectionParacetamol Analgesic
Compatible 10 mg/ml + InjectionAmiodarone hydrochloride 18 mg/ml + Glucose 5%
Compatible 10 mg/ml + InjectionFurosemide 10 mg/ml
Compatible 10 mg/ml + InjectionHeparin sodium 208,3 UI/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + InjectionInsulin 1 UI/ml + Sodium chloride 0,9%
Incompatible 10 mg/ml + InjectionPantoprazole sodium 4 mg/ml + Sodium chloride 0,9%
InjectionPhloroglucinol  Antispasmodic
Compatible 10 mg/ml + InjectionInsulin 1 UI/ml + Sodium chloride 0,9%
Incompatible 0,4 mg/ml + InjectionPantoprazole sodium 4 mg/ml + Sodium chloride 0,9%
InjectionPhytomenadione Vitamin
Compatible 0,2 mg/ml + InjectionAcetylsalicylic acid lysinate 10 mg/ml + Sodium chloride 0,9%
Incompatible 0,2 mg/ml + InjectionPantoprazole sodium 4 mg/ml + Sodium chloride 0,9%
InjectionPotassium chloride Electrolyte
Compatible 1340 mEq/l + InjectionAcetylsalicylic acid lysinate 10 mg/ml + Sodium chloride 0,9%
Compatible 1340 mEq/l + InjectionAmiodarone hydrochloride 3 mg/ml + Glucose 5%
InjectionPyridoxine hydrochloride Vitamin
Compatible 0,5 mg/ml + InjectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
Incompatible 0,0025 mg/ml + InjectionPantoprazole sodium 4 mg/ml + Sodium chloride 0,9%
InjectionRemifentanil hydrochloride Analgesic
Incompatible 100 µg/ml + InjectionInsulin 1 UI/ml + Sodium chloride 0,9%
InjectionSpiramycine adipate Antibiotic
Incompatible 60 MUI/ml + InjectionFurosemide 10 mg/ml
InjectionThiamine hydrochloride Vitamin
Compatible 1 mg/ml + InjectionAcetylsalicylic acid lysinate 10 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionAmiodarone hydrochloride 3 mg/ml + Glucose 5%
Compatible 1 mg/ml + InjectionAtenolol 0,1 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionClonidine hydrochloride 0,0125 mg/ml + Sodium chloride 0,9%
Compatible 0,5 mg/ml + InjectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
Incompatible 1 mg/ml + InjectionPantoprazole sodium 4 mg/ml + Sodium chloride 0,9%
InjectionTramadol hydrochloride Analgesic
Compatible 6,3 mg/ml + InjectionNefopam 0,16 mg/ml + Sodium chloride 0,9%
InjectionUrapidil Antihypertensive
Compatible 5 mg/ml + InjectionAtenolol 0,1 mg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + InjectionClonidine hydrochloride 0,0125 mg/ml + Sodium chloride 0,9%
InjectionVancomycin hydrochloride Antibiotic
Compatible 31,3 mg/ml + InjectionAmiodarone hydrochloride 9 mg/ml + Glucose 5%

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