Last update :
03/02/2023
References   References 3408  
Type : Journal
Web link : http://www.pharmactuel.com/index.php/pharmactuel/issue/view/87

Research teams : Montreal - Centre hospitalier Sainte Justine
Authors : Tollec S, Touzin K, Pelletier E, Forest J.M.
Title : Evaluation visuelle de la compatibilité physique de la naloxone avec d’autres médicaments intraveineux usuels.
Reference : Pharmactuel ; 46, 1 : 16-21. 2013

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionAciclovir sodium Antiviral
Incompatible 50 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionAmikacin sulfate Antibiotic
Compatible 250 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionAminophylline Various
Incompatible 50 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionAmiodarone hydrochloride Anti-arrhythmic
Compatible 50 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionAmphotericin B Antifungal
Incompatible 4 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionAmpicillin sodium Antibiotic
Compatible 250 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionAtropine sulfate Antimuscarinic
Compatible 0.4 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionAzithromycine Antibiotic
Compatible 500 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionCaffeine Respiratory stimulant
Compatible 10 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionCalcium chloride Electrolyte
Compatible 78 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionCalcium gluconate Electrolyte
Compatible 100 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionCaspofungin acetate Antifungal
Compatible 5 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionCefazolin sodium Antibiotic
Incompatible 100 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionCefotaxime sodium Antibiotic
Compatible 100 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionCefoxitin sodium Antibiotic
Compatible 100 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionCeftazidime Antibiotic
Compatible 100 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionCeftriaxone disodium Antibiotic
Compatible 100 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionCefuroxime sodium Antibiotic
Compatible 100 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionChlorpromazine hydrochloride Anxiolytic
Compatible 25 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionCiclosporin Immunosuppressant
Incompatible 50 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionCiprofloxacin lactate Antibiotic
Compatible 2 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionClindamycin phosphate Antibiotic
Compatible 150 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionCloxacillin sodium Antibiotic
Compatible 250 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionCo-trimoxazole Antibiotic
Compatible + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 4 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionDiazepam Anxiolytic
Incompatible 5 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionDigoxin Cardiotonic
Compatible 50 µg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionDimenhydrinate Antihistamine (H1)
Compatible 10 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 50 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionDobutamine hydrochloride Cardiotonic
Compatible 12.5 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionDopamine hydrochloride Cardiotonic
Compatible 40 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionDroperidol Neuroleptic
Compatible 2.5 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 1000 µg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionErythromycin lactobionate Antibiotic
Compatible 50 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionFentanyl citrate Analgesic
Compatible 50 µg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionFluconazole Antifungal
Compatible 2 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionFurosemide Diuretic
Compatible 10 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionGentamicin sulfate Antibiotic
Compatible 40 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionHeparin sodium Anticoagulant
Compatible 1000 UI/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionHydralazine hydrochloride Antihypertensive
Compatible 1 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 125 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionHydromorphone hydrochloride Analgesic
Compatible 10 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionIndomethacin sodium trihydrate Anti-inflammatory
Incompatible 0.5 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionInsulin Glucose-lowering
Compatible 100 UI/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0.2 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionKetamine hydrochloride General anesthetic
Compatible 50 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionL-carnitine Various
Compatible 200 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionLabetalol hydrochloride Beta-blocker
Compatible 5 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionLevofloxacine Antibiotic
Compatible 0.5 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionLidocaine hydrochloride Local anesthetic
Compatible 1 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionLorazepam Anxiolytic
Incompatible 4 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionMagnesium sulfate Electrolyte
Compatible 500 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionMannitol Various
Compatible 250 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionMeropenem Antibiotic
Compatible 50 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionMethylprednisolone acetate Anti-inflammatory
Compatible 62.5 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionMetronidazole Antiparasitic
Compatible 5 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionMidazolam hydrochloride Anxiolytic
Compatible 5 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionMilrinone lactate Cardiotonic
Compatible 1 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionN-acetylcysteine Antidote
Compatible 200 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionNaloxone hydrochloride Antidote
Incompatible 0.4 mg/ml + InjectionAciclovir sodium 50 mg/ml + None
Compatible 0.4 mg/ml + InjectionAmikacin sulfate 250 mg/ml + None
Incompatible 0.4 mg/ml + InjectionAminophylline 50 mg/ml + None
Compatible 0.4 mg/ml + InjectionAmiodarone hydrochloride 50 mg/ml + None
Incompatible 0.4 mg/ml + InjectionAmphotericin B 4 mg/ml + None
Compatible 0.4 mg/ml + InjectionAmpicillin sodium 250 mg/ml + None
Compatible 0.4 mg/ml + InjectionAtropine sulfate 0.4 mg/ml + None
Compatible 0.4 mg/ml + InjectionAzithromycine 500 mg/ml + None
Compatible 0.4 mg/ml + InjectionCaffeine 10 mg/ml + None
Compatible 0.4 mg/ml + InjectionCalcium chloride 78 mg/ml + None
Compatible 0.4 mg/ml + InjectionCalcium gluconate 100 mg/ml + None
Compatible 0.4 mg/ml + InjectionCaspofungin acetate 5 mg/ml + None
Incompatible 0.4 mg/ml + InjectionCefazolin sodium 100 mg/ml + None
Compatible 0.4 mg/ml + InjectionCefotaxime sodium 100 mg/ml + None
Compatible 0.4 mg/ml + InjectionCefoxitin sodium 100 mg/ml + None
Compatible 0.4 mg/ml + InjectionCeftazidime 100 mg/ml + None
Compatible 0.4 mg/ml + InjectionCeftriaxone disodium 100 mg/ml + None
Compatible 0.4 mg/ml + InjectionCefuroxime sodium 100 mg/ml + None
Compatible 0.4 mg/ml + InjectionChlorpromazine hydrochloride 25 mg/ml + None
Incompatible 0.4 mg/ml + InjectionCiclosporin 50 mg/ml + None
Compatible 0.4 mg/ml + InjectionCiprofloxacin lactate 2 mg/ml + None
Compatible 0.4 mg/ml + InjectionClindamycin phosphate 150 mg/ml + None
Compatible 0.4 mg/ml + InjectionCloxacillin sodium 250 mg/ml + None
Compatible 0.4 mg/ml + InjectionCo-trimoxazole + None
Compatible 0.4 mg/ml + InjectionDexamethasone sodium phosphate 4 mg/ml + None
Incompatible 0.4 mg/ml + InjectionDiazepam 5 mg/ml + None
Compatible 0.4 mg/ml + InjectionDigoxin 50 µg/ml + None
Compatible 0.4 mg/ml + InjectionDimenhydrinate 10 mg/ml + None
Compatible 0.4 mg/ml + InjectionDiphenhydramine hydrochloride 50 mg/ml + None
Compatible 0.4 mg/ml + InjectionDobutamine hydrochloride 12.5 mg/ml + None
Compatible 0.4 mg/ml + InjectionDopamine hydrochloride 40 mg/ml + None
Compatible 0.4 mg/ml + InjectionDroperidol 2.5 mg/ml + None
Compatible 0.4 mg/ml + InjectionEpinephrine hydrochloride 1000 µg/ml + None
Compatible 0.4 mg/ml + InjectionErythromycin lactobionate 50 mg/ml + None
Compatible 0.4 mg/ml + InjectionEsmolol hydrochloride 10 mg/ml + None
Compatible 0.4 mg/ml + InjectionFentanyl citrate 50 µg/ml + None
Compatible 0.4 mg/ml + InjectionFluconazole 2 mg/ml + None
Compatible 0.4 mg/ml + InjectionFurosemide 10 mg/ml + None
Compatible 0.4 mg/ml + InjectionGentamicin sulfate 40 mg/ml + None
Compatible 0.4 mg/ml + InjectionHeparin sodium 1000 UI/ml + None
Compatible 0.4 mg/ml + InjectionHydralazine hydrochloride 1 mg/ml + None
Compatible 0.4 mg/ml + InjectionHydrocortisone sodium succinate 125 mg/ml + None
Compatible 0.4 mg/ml + InjectionHydromorphone hydrochloride 10 mg/ml + None
Incompatible 0.4 mg/ml + InjectionIndomethacin sodium trihydrate 0.5 mg/ml + None
Compatible 0.4 mg/ml + InjectionInsulin 100 UI/ml + None
Compatible 0.4 mg/ml + InjectionIsoprenaline hydrochloride 0.2 mg/ml + None
Compatible 0.4 mg/ml + InjectionKetamine hydrochloride 50 mg/ml + None
Compatible 0.4 mg/ml + InjectionL-carnitine 200 mg/ml + None
Compatible 0.4 mg/ml + InjectionLabetalol hydrochloride 5 mg/ml + None
Compatible 0.4 mg/ml + InjectionLevofloxacine 0.5 mg/ml + None
Compatible 0.4 mg/ml + InjectionLidocaine hydrochloride 1 mg/ml + None
Incompatible 0.4 mg/ml + InjectionLorazepam 4 mg/ml + None
Compatible 0.4 mg/ml + InjectionMagnesium sulfate 500 mg/ml + None
Compatible 0.4 mg/ml + InjectionMannitol 250 mg/ml + None
Compatible 0.4 mg/ml + InjectionMeropenem 50 mg/ml + None
Compatible 0.4 mg/ml + InjectionMethylprednisolone acetate 62.5 mg/ml + None
Compatible 0.4 mg/ml + InjectionMetoclopramide hydrochloride 5 mg/ml + None
Compatible 0.4 mg/ml + InjectionMetronidazole 5 mg/ml + None
Compatible 0.4 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
Compatible 0.4 mg/ml + InjectionMilrinone lactate 1 mg/ml + None
Compatible 0.4 mg/ml + InjectionN-acetylcysteine 200 mg/ml + None
Incompatible 0.4 mg/ml + InjectionNitroglycerin 5 mg/ml + None
Compatible 0.4 mg/ml + InjectionNitroprusside sodium 10 mg/ml + None
Compatible 0.4 mg/ml + InjectionNorepinephrine bitartrate 1 mg/ml + None
Compatible 0.4 mg/ml + InjectionOctreotide acetate 0.5 mg/ml + None
Compatible 0.4 mg/ml + InjectionOndansetron hydrochloride 2 mg/ml + None
Compatible 0.4 mg/ml + InjectionOxytocin 10 UI/ml + None
Compatible 0.4 mg/ml + InjectionPancuronium bromide 2 mg/ml + None
Incompatible 0.4 mg/ml + InjectionPantoprazole sodium 4 mg/ml + None
Compatible 0.4 mg/ml + InjectionPhenobarbital sodium 60 mg/ml + None
Incompatible 0.4 mg/ml + InjectionPhenytoin sodium 50 mg/ml + None
Compatible 0.4 mg/ml + InjectionPiperacillin sodium 200 mg/ml + None
Compatible 0.4 mg/ml + InjectionPiperacillin sodium / tazobactam 200 mg/ml + None
Compatible 0.4 mg/ml + InjectionPotassium chloride 200 mEq/l + None
Compatible 0.4 mg/ml + InjectionPotassium phosphate 3 mmol/ml + None
Compatible 0.4 mg/ml + InjectionPromethazine hydrochloride 25 mg/ml + None
Compatible 0.4 mg/ml + InjectionPropranolol hydrochloride 1 mg/ml + None
Compatible 0.4 mg/ml + InjectionRanitidine hydrochloride 25 mg/ml + None
Compatible 0.4 mg/ml + InjectionRocuronium bromide 10 mg/ml + None
Compatible 0.4 mg/ml + InjectionSalbutamol sulfate 1 mg/ml + None
Compatible 0.4 mg/ml + InjectionSodium bicarbonate 84 mg/ml + None
Compatible 0.4 mg/ml + InjectionSufentanil citrate 0.05 mg/ml + None
Incompatible 0.4 mg/ml + InjectionThiopental sodium 125 mg/ml + None
Compatible 0.4 mg/ml + InjectionTicarcillin / clavulanic acid 200 mg/ml + None
Compatible 0.4 mg/ml + InjectionTobramycin sulfate 40 mg/ml + None
Compatible 0.4 mg/ml + InjectionValproic acid 100 mg/ml + None
Compatible 0.4 mg/ml + InjectionVancomycin hydrochloride 50 mg/ml + None
Compatible 0.4 mg/ml + InjectionVoriconazole 10 mg/ml + None
InjectionNitroglycerin Vasodilator
Incompatible 5 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionNitroprusside sodium Vasodilator
Compatible 10 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionNorepinephrine bitartrate Sympathomimetic
Compatible 1 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionOctreotide acetate Various
Compatible 0.5 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionOndansetron hydrochloride Antiemetic
Compatible 2 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionOxytocin Various
Compatible 10 UI/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionPancuronium bromide Curarimimetic
Compatible 2 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionPantoprazole sodium Proton pump inhibitor
Incompatible 4 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionPhenobarbital sodium Antiepileptic
Compatible 60 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionPhenytoin sodium Antiepileptic
Incompatible 50 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionPiperacillin sodium Antibiotic
Compatible 200 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionPiperacillin sodium / tazobactam Antibiotic
Compatible 200 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionPotassium chloride Electrolyte
Compatible 200 mEq/l + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionPotassium phosphate Electrolyte
Compatible 3 mmol/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionPromethazine hydrochloride Antihistamine (H1)
Compatible 25 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionPropranolol hydrochloride Beta-blocker
Compatible 1 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 25 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionRocuronium bromide Curarimimetic
Compatible 10 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionSalbutamol sulfate Beta-stimulant
Compatible 1 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionSufentanil citrate Analgesic
Compatible 0.05 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionThiopental sodium General anesthetic
Incompatible 125 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionTicarcillin / clavulanic acid Antibiotic
Compatible 200 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionTobramycin sulfate Antibiotic
Compatible 40 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionValproic acid Antiepileptic
Compatible 100 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionVancomycin hydrochloride Antibiotic
Compatible 50 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None
InjectionVoriconazole Antifungal
Compatible 10 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + None

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