Last update :
19/04/2021
References   References 4528  
Type : Journal

Research teams : Oklahoma City - Analytical Research Laboratories (T.C.K.)
Authors : Lu J, Liu Q, Kupiec T, Vail H, Lunch L, Fam D, Vu N.
Title : Physical Compatibility of Cefiderocol with Selected Intravenous Drugs During Simulated Y-site Administration.
Reference : Int J Pharm Compound ;25,1:52-61 2021

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionAciclovir sodium Antiviral
Incompatible 7 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionAminophylline Various
Incompatible 1 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + Sodium chloride 0,9%
InjectionAmiodarone hydrochloride Anti-arrhythmic
Incompatible 4 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionAmphotericin B Antifungal
Incompatible 1 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionCaspofungin acetate Antifungal
Incompatible 0.5 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionCefiderocol sulfate tosylate Antibiotic
Incompatible 20 mg/mL + InjectionAciclovir sodium 7 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionAminophylline 1 mg/ml + Sodium chloride 0,9%
Incompatible 20 mg/mL + InjectionAmiodarone hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionAmphotericin B 1 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionCaspofungin acetate 0.5 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
Incompatible 20 mg/mL + InjectionDiphenhydramine hydrochloride 50 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionDobutamine hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionDoxycycline hyclate 1 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionEsomeprazole sodium 0.8 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionFamotidine 4 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionHuman albumin 250 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionLabetalol hydrochloride 5 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionLorazepam 1 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionMethylprednisolone acetate 20 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionMycophenolate mofetil 6 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionPhenytoin sodium 10 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionPolymyxine B 0.125 mg/ml + Glucose 5%
Incompatible 20 mg/mL + InjectionPosaconazole 2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionPropofol 10 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionRocuronium bromide 5 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionTobramycin sulfate 10 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 20 mg/mL + InjectionVancomycin hydrochloride 5 mg/ml + NaCl 0,9% or Glucose 5%
InjectionCiprofloxacin lactate Antibiotic
Incompatible 2 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + Glucose 5%
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Incompatible 50 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionDobutamine hydrochloride Cardiotonic
Incompatible 4 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionDoxycycline hyclate Antibiotic
Incompatible 1 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionEsomeprazole sodium Proton pump inhibitor
Incompatible 0.8 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionFamotidine Antihistamine (H2)
Incompatible 4 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionHuman albumin Various
Incompatible 250 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionLabetalol hydrochloride Beta-blocker
Incompatible 5 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionLorazepam Anxiolytic
Incompatible 1 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionMethylprednisolone acetate Anti-inflammatory
Incompatible 20 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionMycophenolate mofetil Immunosuppressant
Incompatible 6 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionPhenytoin sodium Antiepileptic
Incompatible 10 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionPolymyxine B Antibiotic
Incompatible 0.125 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + Glucose 5%
InjectionPosaconazole Antifungal
Incompatible 2 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionPropofol General anesthetic
Incompatible 10 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionRocuronium bromide Curarimimetic
Incompatible 5 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionTobramycin sulfate Antibiotic
Incompatible 10 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%
InjectionVancomycin hydrochloride Antibiotic
Incompatible 5 mg/ml + InjectionCefiderocol sulfate tosylate 20 mg/mL + NaCl 0,9% or Glucose 5%

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