Last update :
15/10/2021
References   References 4603  
Type : Journal
Web link : https://journals.sagepub.com/doi/10.1177/0018578719888913

Research teams : Montreal - Centre hospitalier Sainte Justine
Authors : Vallée M, Barthélémy I, Friciu M, Pelletier E, Forest J.M, Benoit F, Leclair G.
Title : Compatibility of Lactated Ringer’s Injection With 94 Selected Intravenous Drugs During Simulated Y-site Administration.
Reference : Hosp Pharm ; 56, 4: 228-234. 2021

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionAcetazolamide Diuretic
Compatible 100 mg/ml + Ringer’s lactate solution
InjectionAciclovir sodium Antiviral
Compatible 50 mg/ml + Ringer’s lactate solution
InjectionAmikacin sulfate Antibiotic
Compatible 250 mg/ml + Ringer’s lactate solution
InjectionAminophylline Various
Compatible 25 mg/ml + Ringer’s lactate solution
InjectionAmiodarone hydrochloride Anti-arrhythmic
Compatible 50 mg/ml + Ringer’s lactate solution
InjectionAmphotericin B liposomale Antifungal
Compatible 4 mg/ml + Ringer’s lactate solution
InjectionAmpicillin sodium Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
InjectionAtropine sulfate Antimuscarinic
Compatible 0,4 mg/ml + Ringer’s lactate solution
InjectionAzithromycine Antibiotic
Compatible 500 mg/ml + Ringer’s lactate solution
InjectionBretylium tosilate Anti-arrhythmic
Compatible 50 mg/ml + Ringer’s lactate solution
InjectionBupivacaine hydrochloride Local anesthetic
Compatible 5 mg/ml + Ringer’s lactate solution
InjectionCaffeine citrate Respiratory stimulant
Compatible 10 mg/ml + Ringer’s lactate solution
InjectionCalcium chloride Electrolyte
Compatible 100 mg/ml + Ringer’s lactate solution
InjectionCalcium gluconate Electrolyte
Compatible 100 mg/ml + Ringer’s lactate solution
InjectionCaspofungin acetate Antifungal
Compatible 5 mg/ml + Ringer’s lactate solution
InjectionCefazolin sodium Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
InjectionCefotaxime sodium Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
InjectionCefoxitin sodium Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
InjectionCeftazidime Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
InjectionCeftriaxone disodium Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
InjectionCefuroxime sodium Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
InjectionChlorpromazine hydrochloride Anxiolytic
Compatible 25 mg/ml + Ringer’s lactate solution
InjectionCiclosporin Immunosuppressant
Incompatible 50 mg/ml + Ringer’s lactate solution
InjectionCiprofloxacin lactate Antibiotic
Incompatible 2 mg/ml + Ringer’s lactate solution
InjectionCloxacillin sodium Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 4 mg/ml + Ringer’s lactate solution
InjectionDexmedetomidine Sympathomimetic
Compatible 100 µg/ml + Ringer’s lactate solution
InjectionDiazepam Anxiolytic
Incompatible 5 mg/ml + Ringer’s lactate solution
InjectionDigoxin Cardiotonic
Compatible 50 µg/ml + Ringer’s lactate solution
InjectionDimenhydrinate Antihistamine (H1)
Compatible 10 mg/ml + Ringer’s lactate solution
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 50 mg/ml + Ringer’s lactate solution
InjectionDobutamine hydrochloride Cardiotonic
Compatible 12,5 mg/ml + Ringer’s lactate solution
InjectionDopamine hydrochloride Cardiotonic
Compatible 3,2 mg/ml + Ringer’s lactate solution
InjectionEnalaprilate Antihypertensive
Compatible 1,25 mg/ml + Ringer’s lactate solution
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 1000 µg/ml + Ringer’s lactate solution
InjectionErythromycin lactobionate Antibiotic
Compatible 50 mg/ml + Ringer’s lactate solution
InjectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + Ringer’s lactate solution
InjectionFentanyl citrate Analgesic
Compatible 50 µg/ml + Ringer’s lactate solution
InjectionFluconazole Antifungal
Compatible 2 mg/ml + Ringer’s lactate solution
InjectionFurosemide Diuretic
Compatible 10 mg/ml + Ringer’s lactate solution
InjectionGentamicin sulfate Antibiotic
Compatible 10 mg/ml + Ringer’s lactate solution
InjectionGranisetron hydrochloride Antiemetic
Compatible 1 mg/ml + Ringer’s lactate solution
InjectionHaloperidol lactate Neuroleptic
Compatible 5 mg/ml + Ringer’s lactate solution
InjectionHeparin sodium Anticoagulant
Compatible 1000 UI/ml + Ringer’s lactate solution
InjectionHuman albumin Various
Compatible 250 mg/ml + Ringer’s lactate solution
InjectionHydralazine hydrochloride Antihypertensive
Compatible 20 mg/ml + Ringer’s lactate solution
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 50 mg/ml + Ringer’s lactate solution
InjectionHydromorphone hydrochloride Analgesic
Compatible 10 mg/ml + Ringer’s lactate solution
InjectionHydroxyzine dihydrochloride Anxiolytic
Compatible 50 mg/ml + Ringer’s lactate solution
InjectionInsulin Glucose-lowering
Compatible 100 UI/ml + Ringer’s lactate solution
InjectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0.2 mg/ml + Ringer’s lactate solution
InjectionKetamine hydrochloride General anesthetic
Incompatible 50 mg/ml + Ringer’s lactate solution
InjectionLabetalol hydrochloride Beta-blocker
Compatible 5 mg/ml + Ringer’s lactate solution
InjectionLidocaine hydrochloride Local anesthetic
Compatible 10 mg/ml + Ringer’s lactate solution
InjectionLinezolid Antibiotic
Compatible 2 mg/ml + Ringer’s lactate solution
InjectionLorazepam Anxiolytic
Incompatible 4 mg/ml + Ringer’s lactate solution
InjectionMagnesium sulfate Electrolyte
Compatible 500 mg/ml + Ringer’s lactate solution
InjectionMannitol Various
Compatible 250 mg/ml + Ringer’s lactate solution
InjectionMeropenem Antibiotic
Compatible 50 mg/ml + Ringer’s lactate solution
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 62,5 mg/ml + Ringer’s lactate solution
InjectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + Ringer’s lactate solution
InjectionMetronidazole Antiparasitic
Compatible 5 mg/ml + Ringer’s lactate solution
InjectionMidazolam hydrochloride Anxiolytic
Compatible 5 mg/ml + Ringer’s lactate solution
InjectionMilrinone lactate Cardiotonic
Compatible 1 mg/ml + Ringer’s lactate solution
InjectionMorphine sulfate Analgesic
Compatible 50 mg/ml + Ringer’s lactate solution
InjectionN-acetylcysteine Antidote
Compatible 200 mg/ml + Ringer’s lactate solution
InjectionNaloxone hydrochloride Antidote
Compatible 0,4 mg/ml + Ringer’s lactate solution
InjectionNicardipine hydrochloride Vasodilator
Compatible 0,2 mg/ml + Ringer’s lactate solution
InjectionNitroglycerin Vasodilator
Incompatible 5 mg/ml + Ringer’s lactate solution
InjectionNitroprusside sodium Vasodilator
Compatible 25 mg/ml + Ringer’s lactate solution
InjectionNorepinephrine bitartrate Sympathomimetic
Compatible 1 mg/ml + Ringer’s lactate solution
InjectionOctreotide acetate Various
Compatible 0,5 mg/ml + Ringer’s lactate solution
InjectionOxytocin Various
Compatible 10 UI/ml + Ringer’s lactate solution
InjectionPenicillin G sodium Antibiotic
Compatible 500 000 MUI/ml + Ringer’s lactate solution
InjectionPhenytoin sodium Antiepileptic
Incompatible 50 mg/ml + Ringer’s lactate solution
InjectionPiperacillin sodium Antibiotic
Compatible 200 mg/ml + Ringer’s lactate solution
InjectionPiperacillin sodium / tazobactam Antibiotic
Compatible 200 mg/ml + Ringer’s lactate solution
InjectionPotassium chloride Electrolyte
Compatible 2 mEq/l + Ringer’s lactate solution
InjectionPotassium phosphate Electrolyte
Compatible 3 mmol/ml + Ringer’s lactate solution
InjectionPropofol General anesthetic
Incompatible 10 mg/ml + Ringer’s lactate solution
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 25 mg/ml + Ringer’s lactate solution
InjectionRocuronium bromide Curarimimetic
Compatible 10 mg/ml + Ringer’s lactate solution
InjectionSalbutamol sulfate Beta-stimulant
Compatible 1 mg/ml + Ringer’s lactate solution
InjectionSodium bicarbonate Electrolyte
Compatible 1 mg/ml + Ringer’s lactate solution
InjectionTobramycin sulfate Antibiotic
Compatible 40 mg/ml + Ringer’s lactate solution
InjectionVancomycin hydrochloride Antibiotic
Compatible 50 mg/ml + Ringer’s lactate solution
InjectionVerapamil hydrochloride Anti-arrhythmic
Compatible 2,5 mg/ml + Ringer’s lactate solution
InjectionVoriconazole Antifungal
Compatible 10 mg/ml + Ringer’s lactate solution

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