Last update :
19/11/2024
References   References 3408  
Type : Journal
Web link : http://www.pharmactuel.com/index.php/pharmactuel/issue/view/87

Research teams : Montreal - Centre hospitalier Sainte Justine
Authors : Tollec S, Touzin K, Pelletier E, Forest J.M.
Title : Evaluation visuelle de la compatibilité physique de la naloxone avec d’autres médicaments intraveineux usuels.
Reference : Pharmactuel ; 46, 1 : 16-21. 2013

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAciclovir sodium Antiviral
Incompatible 50 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionAmikacin sulfate Antibiotic
Compatible 250 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionAminophylline Various
Incompatible 50 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionAmiodarone hydrochloride Anti-arrhythmic
Compatible 50 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionAmphotericin B Antifungal
Incompatible 4 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionAmpicillin sodium Antibiotic
Compatible 250 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionAtropine sulfate Antimuscarinic
Compatible 0.4 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionAzithromycine Antibiotic
Compatible 500 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionCaffeine Respiratory stimulant
Compatible 10 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionCalcium chloride Electrolyte
Compatible 78 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionCalcium gluconate Electrolyte
Compatible 100 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionCaspofungin acetate Antifungal
Compatible 5 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionCefazolin sodium Antibiotic
Incompatible 100 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionCefotaxime sodium Antibiotic
Compatible 100 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionCefoxitin sodium Antibiotic
Compatible 100 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionCeftazidime Antibiotic
Compatible 100 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionCeftriaxone disodium Antibiotic
Compatible 100 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionCefuroxime sodium Antibiotic
Compatible 100 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionChlorpromazine hydrochloride Anxiolytic
Compatible 25 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionCiclosporin Immunosuppressant
Incompatible 50 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionCiprofloxacin lactate Antibiotic
Compatible 2 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionClindamycin phosphate Antibiotic
Compatible 150 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionCloxacillin sodium Antibiotic
Compatible 250 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionCo-trimoxazole Antibiotic
Compatible + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 4 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionDiazepam Anxiolytic
Incompatible 5 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionDigoxin Cardiotonic
Compatible 50 µg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionDimenhydrinate Antihistamine (H1)
Compatible 10 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 50 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionDobutamine hydrochloride Cardiotonic
Compatible 12.5 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionDopamine hydrochloride Cardiotonic
Compatible 40 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionDroperidol Neuroleptic
Compatible 2.5 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 1000 µg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionErythromycin lactobionate Antibiotic
Compatible 50 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionFentanyl citrate Analgesic
Compatible 50 µg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionFurosemide Diuretic
Compatible 10 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionGentamicin sulfate Antibiotic
Compatible 40 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionHeparin sodium Anticoagulant
Compatible 1000 UI/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionHydralazine hydrochloride Antihypertensive
Compatible 1 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 125 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionHydromorphone hydrochloride Analgesic
Compatible 10 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionIndomethacin sodium trihydrate Anti-inflammatory
Incompatible 0.5 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionInsulin Glucose-lowering
Compatible 100 UI/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0.2 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionKetamine hydrochloride General anesthetic
Compatible 50 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionL-carnitine Various
Compatible 200 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionLabetalol hydrochloride Beta-blocker
Compatible 5 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionLevofloxacine Antibiotic
Compatible 0.5 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionLidocaine hydrochloride Local anesthetic
Compatible 1 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionLorazepam Anxiolytic
Incompatible 4 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionMagnesium sulfate Electrolyte
Compatible 500 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionMannitol Various
Compatible 250 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionMeropenem Antibiotic
Compatible 50 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionMethylprednisolone acetate Anti-inflammatory
Compatible 62.5 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionMidazolam hydrochloride Anxiolytic
Compatible 5 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionMilrinone lactate Cardiotonic
Compatible 1 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionN-acetylcysteine Antidote
Compatible 200 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionNaloxone hydrochloride Antidote
Incompatible 0.4 mg/ml + injectionAciclovir sodium 50 mg/ml + None
Compatible 0.4 mg/ml + injectionAmikacin sulfate 250 mg/ml + None
Incompatible 0.4 mg/ml + injectionAminophylline 50 mg/ml + None
Compatible 0.4 mg/ml + injectionAmiodarone hydrochloride 50 mg/ml + None
Incompatible 0.4 mg/ml + injectionAmphotericin B 4 mg/ml + None
Compatible 0.4 mg/ml + injectionAmpicillin sodium 250 mg/ml + None
Compatible 0.4 mg/ml + injectionAtropine sulfate 0.4 mg/ml + None
Compatible 0.4 mg/ml + injectionAzithromycine 500 mg/ml + None
Compatible 0.4 mg/ml + injectionCaffeine 10 mg/ml + None
Compatible 0.4 mg/ml + injectionCalcium chloride 78 mg/ml + None
Compatible 0.4 mg/ml + injectionCalcium gluconate 100 mg/ml + None
Compatible 0.4 mg/ml + injectionCaspofungin acetate 5 mg/ml + None
Incompatible 0.4 mg/ml + injectionCefazolin sodium 100 mg/ml + None
Compatible 0.4 mg/ml + injectionCefotaxime sodium 100 mg/ml + None
Compatible 0.4 mg/ml + injectionCefoxitin sodium 100 mg/ml + None
Compatible 0.4 mg/ml + injectionCeftazidime 100 mg/ml + None
Compatible 0.4 mg/ml + injectionCeftriaxone disodium 100 mg/ml + None
Compatible 0.4 mg/ml + injectionCefuroxime sodium 100 mg/ml + None
Compatible 0.4 mg/ml + injectionChlorpromazine hydrochloride 25 mg/ml + None
Incompatible 0.4 mg/ml + injectionCiclosporin 50 mg/ml + None
Compatible 0.4 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + None
Compatible 0.4 mg/ml + injectionClindamycin phosphate 150 mg/ml + None
Compatible 0.4 mg/ml + injectionCloxacillin sodium 250 mg/ml + None
Compatible 0.4 mg/ml + injectionCo-trimoxazole + None
Compatible 0.4 mg/ml + injectionDexamethasone sodium phosphate 4 mg/ml + None
Incompatible 0.4 mg/ml + injectionDiazepam 5 mg/ml + None
Compatible 0.4 mg/ml + injectionDigoxin 50 µg/ml + None
Compatible 0.4 mg/ml + injectionDimenhydrinate 10 mg/ml + None
Compatible 0.4 mg/ml + injectionDiphenhydramine hydrochloride 50 mg/ml + None
Compatible 0.4 mg/ml + injectionDobutamine hydrochloride 12.5 mg/ml + None
Compatible 0.4 mg/ml + injectionDopamine hydrochloride 40 mg/ml + None
Compatible 0.4 mg/ml + injectionDroperidol 2.5 mg/ml + None
Compatible 0.4 mg/ml + injectionEpinephrine hydrochloride 1000 µg/ml + None
Compatible 0.4 mg/ml + injectionErythromycin lactobionate 50 mg/ml + None
Compatible 0.4 mg/ml + injectionEsmolol hydrochloride 10 mg/ml + None
Compatible 0.4 mg/ml + injectionFentanyl citrate 50 µg/ml + None
Compatible 0.4 mg/ml + injectionFluconazole 2 mg/ml + None
Compatible 0.4 mg/ml + injectionFurosemide 10 mg/ml + None
Compatible 0.4 mg/ml + injectionGentamicin sulfate 40 mg/ml + None
Compatible 0.4 mg/ml + injectionHeparin sodium 1000 UI/ml + None
Compatible 0.4 mg/ml + injectionHydralazine hydrochloride 1 mg/ml + None
Compatible 0.4 mg/ml + injectionHydrocortisone sodium succinate 125 mg/ml + None
Compatible 0.4 mg/ml + injectionHydromorphone hydrochloride 10 mg/ml + None
Incompatible 0.4 mg/ml + injectionIndomethacin sodium trihydrate 0.5 mg/ml + None
Compatible 0.4 mg/ml + injectionInsulin 100 UI/ml + None
Compatible 0.4 mg/ml + injectionIsoprenaline hydrochloride 0.2 mg/ml + None
Compatible 0.4 mg/ml + injectionKetamine hydrochloride 50 mg/ml + None
Compatible 0.4 mg/ml + injectionL-carnitine 200 mg/ml + None
Compatible 0.4 mg/ml + injectionLabetalol hydrochloride 5 mg/ml + None
Compatible 0.4 mg/ml + injectionLevofloxacine 0.5 mg/ml + None
Compatible 0.4 mg/ml + injectionLidocaine hydrochloride 1 mg/ml + None
Incompatible 0.4 mg/ml + injectionLorazepam 4 mg/ml + None
Compatible 0.4 mg/ml + injectionMagnesium sulfate 500 mg/ml + None
Compatible 0.4 mg/ml + injectionMannitol 250 mg/ml + None
Compatible 0.4 mg/ml + injectionMeropenem 50 mg/ml + None
Compatible 0.4 mg/ml + injectionMethylprednisolone acetate 62.5 mg/ml + None
Compatible 0.4 mg/ml + injectionMetoclopramide hydrochloride 5 mg/ml + None
Compatible 0.4 mg/ml + injectionMetronidazole 5 mg/ml + None
Compatible 0.4 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
Compatible 0.4 mg/ml + injectionMilrinone lactate 1 mg/ml + None
Compatible 0.4 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
Incompatible 0.4 mg/ml + injectionNitroglycerin 5 mg/ml + None
Compatible 0.4 mg/ml + injectionNitroprusside sodium 10 mg/ml + None
Compatible 0.4 mg/ml + injectionNorepinephrine bitartrate 1 mg/ml + None
Compatible 0.4 mg/ml + injectionOctreotide acetate 0.5 mg/ml + None
Compatible 0.4 mg/ml + injectionOndansetron hydrochloride 2 mg/ml + None
Compatible 0.4 mg/ml + injectionOxytocin 10 UI/ml + None
Compatible 0.4 mg/ml + injectionPancuronium bromide 2 mg/ml + None
Incompatible 0.4 mg/ml + injectionPantoprazole sodium 4 mg/ml + None
Compatible 0.4 mg/ml + injectionPhenobarbital sodium 60 mg/ml + None
Incompatible 0.4 mg/ml + injectionPhenytoin sodium 50 mg/ml + None
Compatible 0.4 mg/ml + injectionPiperacillin sodium 200 mg/ml + None
Compatible 0.4 mg/ml + injectionPiperacillin sodium / tazobactam 200 mg/ml + None
Compatible 0.4 mg/ml + injectionPotassium chloride 200 mEq/l + None
Compatible 0.4 mg/ml + injectionPotassium phosphate 3 mmol/ml + None
Compatible 0.4 mg/ml + injectionPromethazine hydrochloride 25 mg/ml + None
Compatible 0.4 mg/ml + injectionPropranolol hydrochloride 1 mg/ml + None
Compatible 0.4 mg/ml + injectionRanitidine hydrochloride 25 mg/ml + None
Compatible 0.4 mg/ml + injectionRocuronium bromide 10 mg/ml + None
Compatible 0.4 mg/ml + injectionSalbutamol sulfate 1 mg/ml + None
Compatible 0.4 mg/ml + injectionSodium bicarbonate 84 mg/ml + None
Compatible 0.4 mg/ml + injectionSufentanil citrate 0.05 mg/ml + None
Incompatible 0.4 mg/ml + injectionThiopental sodium 125 mg/ml + None
Compatible 0.4 mg/ml + injectionTicarcillin / clavulanic acid 200 mg/ml + None
Compatible 0.4 mg/ml + injectionTobramycin sulfate 40 mg/ml + None
Compatible 0.4 mg/ml + injectionValproic acid 100 mg/ml + None
Compatible 0.4 mg/ml + injectionVancomycin hydrochloride 50 mg/ml + None
Compatible 0.4 mg/ml + injectionVoriconazole 10 mg/ml + None
injectionNitroglycerin Vasodilator
Incompatible 5 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionNitroprusside sodium Vasodilator
Compatible 10 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 1 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionOctreotide acetate Various
Compatible 0.5 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionOndansetron hydrochloride Antiemetic
Compatible 2 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionOxytocin Various
Compatible 10 UI/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionPancuronium bromide Curarimimetic
Compatible 2 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionPantoprazole sodium Proton pump inhibitor
Incompatible 4 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionPhenobarbital sodium Antiepileptic
Compatible 60 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionPhenytoin sodium Antiepileptic
Incompatible 50 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionPiperacillin sodium Antibiotic
Compatible 200 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionPiperacillin sodium / tazobactam Antibiotic
Compatible 200 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionPotassium chloride Electrolyte
Compatible 200 mEq/l + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionPotassium phosphate Electrolyte
Compatible 3 mmol/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionPromethazine hydrochloride Antihistamine (H1)
Compatible 25 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionPropranolol hydrochloride Beta-blocker
Compatible 1 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 25 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionRocuronium bromide Curarimimetic
Compatible 10 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionSalbutamol sulfate Beta-stimulant
Compatible 1 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionSufentanil citrate Analgesic
Compatible 0.05 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionThiopental sodium General anesthetic
Incompatible 125 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionTicarcillin / clavulanic acid Antibiotic
Compatible 200 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionTobramycin sulfate Antibiotic
Compatible 40 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionValproic acid Antiepileptic
Compatible 100 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionVancomycin hydrochloride Antibiotic
Compatible 50 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None
injectionVoriconazole Antifungal
Compatible 10 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + None

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