Bibliographie - 4698 - Stabilis 4.0

Last update :
18/04/2024

References 4698

Type :

Journal

Research teams :

Nancy - University Hospital of Nancy, Department of Pharmacy

Authors :

Ayari G, D'Huart E, Vigneron J, Demoré B.

Title :

Y-site compatibility of intravenous medications commonly used in intensive care units : laboratory tests on 75 mixtures involving nine main drugs.

Reference :

Pharmaceutical Technology in Hospital Pharmacy 2022

Level of Evidence :

Physical stability :

Chemical stability :

Other methods :

Comments :

Not rated: compatibility study only

List of drugs

Acetylsalicylic acid lysinate

10 mg/ml	+ Hydrocortisone sodium succinate	2 mg/ml	+
10 mg/ml	+ Insulin	1 UI/ml	+
10 mg/ml	+ Magnesium sulfate	6 mg/ml	+
10 mg/ml	+ Nefopam	0,08 mg/ml	+
10 mg/ml	+ Phytomenadione	0,2 mg/ml	+
10 mg/ml	+ Potassium chloride	1340 mEq/l	+
10 mg/ml	+ Thiamine hydrochloride	1 mg/ml	+

Amiodarone hydrochloride

3 mg/ml	+ Bumetanide	0,2 mg/ml	+
3 mg/ml	+ Cefazolin sodium	40 mg/ml	+
9 mg/ml	+ Cefotaxime sodium	40 mg/ml	+
18 mg/ml	+ Furosemide	5 mg/ml	+
9 mg/ml	+ Hydrocortisone sodium succinate	2 mg/ml	+
6 mg/ml	+ Insulin	1 UI/ml	+
3 mg/ml	+ Levofloxacine	5 mg/ml	+
9 mg/ml	+ Magnesium sulfate	1,5 mg/ml	+
9 mg/ml	+ Nefopam	0,16 mg/ml	+
18 mg/ml	+ Paracetamol	10 mg/ml	+
3 mg/ml	+ Potassium chloride	1340 mEq/l	+
3 mg/ml	+ Thiamine hydrochloride	2 mg/ml	+
9 mg/ml	+ Vancomycin hydrochloride	31,3 mg/ml	+

Atenolol

0,1 mg/ml	+ Ciclosporin	10 mg/ml	+
0,1 mg/ml	+ Methylprednisolone sodium succinate	0,2 mg/ml	+
0,1 mg/ml	+ Metronidazole	5 mg/ml	+
0,1 mg/ml	+ Mycophenolate mofetil	10 mg/ml	+
0,1 mg/ml	+ Thiamine hydrochloride	1 mg/ml	+
0,1 mg/ml	+ Urapidil	5 mg/ml	+

Bumetanide

0,2 mg/ml

Amiodarone hydrochloride

3 mg/ml

Calcium chloride

2 mg/ml

Nefopam

0,8 mg/ml

Cefazolin sodium

40 mg/ml

Amiodarone hydrochloride

3 mg/ml

Cefotaxime sodium

	40 mg/ml	+ Amiodarone hydrochloride	9 mg/ml	+
	40 mg/ml	+ Nefopam	0,16 mg/ml	+

Ciclosporin

10 mg/ml

Atenolol

0,1 mg/ml

Clonidine hydrochloride

0,0125 mg/ml	+ Methylprednisolone sodium succinate	0,2 mg/ml	+
0,0125 mg/ml	+ Mycophenolate mofetil	10 mg/ml	+
0,0125 mg/ml	+ Thiamine hydrochloride	1 mg/ml	+
0,0125 mg/ml	+ Urapidil	5 mg/ml	+

Furosemide

5 mg/ml	+ Amiodarone hydrochloride	18 mg/ml	+
10 mg/ml	+ Magnesium sulfate	6 mg/ml
10 mg/ml	+ Nefopam	1,7 mg/ml
10 mg/ml	+ Paracetamol	10 mg/ml
10 mg/ml	+ Spiramycine adipate	60 MUI/ml

Heparin sodium

208,3 UI/ml	+ Levetiracetam	15 mg/ml	+
208,3 UI/ml	+ Midazolam hydrochloride	1 mg/ml	+
208,3 UI/ml	+ Nefopam	1,7 mg/ml	+
208,3 UI/ml	+ Paracetamol	10 mg/ml	+

Hydrocortisone sodium succinate

2 mg/ml	+ Acetylsalicylic acid lysinate	10 mg/ml	+
2 mg/ml	+ Amiodarone hydrochloride	9 mg/ml	+
2 mg/ml	+ Nefopam	0,16 mg/ml	+

Insulin

1 UI/ml	+ Acetylsalicylic acid lysinate	10 mg/ml	+
1 UI/ml	+ Amiodarone hydrochloride	6 mg/ml	+
1 UI/ml	+ Isosorbide dinitrate	1 mg/ml	+
1 UI/ml	+ Nefopam	0,16 mg/ml	+
1 UI/ml	+ Pantoprazole sodium	1 mg/ml	+
1 UI/ml	+ Paracetamol	10 mg/ml	+
1 UI/ml	+ Phloroglucinol	10 mg/ml	+
1 UI/ml	+ Remifentanil hydrochloride	100 µg/ml	+

Isosorbide dinitrate

	1 mg/ml	+ Insulin	1 UI/ml	+
	1 mg/ml	+ Nefopam	0,16 mg/ml	+

Levetiracetam

15 mg/ml

Heparin sodium

208,3 UI/ml

Levofloxacine

5 mg/ml

Amiodarone hydrochloride

3 mg/ml

Magnesium sulfate

6 mg/ml	+ Acetylsalicylic acid lysinate	10 mg/ml	+
1,5 mg/ml	+ Amiodarone hydrochloride	9 mg/ml	+
6 mg/ml	+ Furosemide	10 mg/ml
3>>4,5 mg/ml	+ Nefopam	0,16 mg/ml	+

Methylprednisolone sodium succinate

	0,2 mg/ml	+ Atenolol	0,1 mg/ml	+
	0,2 mg/ml	+ Clonidine hydrochloride	0,0125 mg/ml	+

Metronidazole

5 mg/ml

Atenolol

0,1 mg/ml

Midazolam hydrochloride

1 mg/ml

Heparin sodium

208,3 UI/ml

Mycophenolate mofetil

	10 mg/ml	+ Atenolol	0,1 mg/ml	+
	10 mg/ml	+ Clonidine hydrochloride	0,0125 mg/ml	+

Nefopam

0,08 mg/ml	+ Acetylsalicylic acid lysinate	10 mg/ml	+
0,16 mg/ml	+ Amiodarone hydrochloride	9 mg/ml	+
0,8 mg/ml	+ Calcium chloride	2 mg/ml	+
0,16 mg/ml	+ Cefotaxime sodium	40 mg/ml	+
1,7 mg/ml	+ Furosemide	10 mg/ml
1,7 mg/ml	+ Heparin sodium	208,3 UI/ml	+
0,16 mg/ml	+ Hydrocortisone sodium succinate	2 mg/ml	+
0,16 mg/ml	+ Insulin	1 UI/ml	+
0,16 mg/ml	+ Isosorbide dinitrate	1 mg/ml	+
0,16 mg/ml	+ Magnesium sulfate	3>>4,5 mg/ml	+
0,16 mg/ml	+ Nicardipine hydrochloride	1 mg/ml	+
0,16 mg/ml	+ Pyridoxine hydrochloride	0,5 mg/ml	+
0,16 mg/ml	+ Thiamine hydrochloride	0,5 mg/ml	+
0,16 mg/ml	+ Tramadol hydrochloride	6,3 mg/ml	+

Nicardipine hydrochloride

1 mg/ml

Nefopam

0,16 mg/ml

Pantoprazole sodium

1 mg/ml	+ Insulin	1 UI/ml	+
4 mg/ml	+ Paracetamol	10 mg/ml	+
4 mg/ml	+ Phloroglucinol	0,4 mg/ml	+
4 mg/ml	+ Phytomenadione	0,2 mg/ml	+
4 mg/ml	+ Pyridoxine hydrochloride	0,0025 mg/ml	+
4 mg/ml	+ Thiamine hydrochloride	1 mg/ml	+

Paracetamol

10 mg/ml	+ Amiodarone hydrochloride	18 mg/ml	+
10 mg/ml	+ Furosemide	10 mg/ml
10 mg/ml	+ Heparin sodium	208,3 UI/ml	+
10 mg/ml	+ Insulin	1 UI/ml	+
10 mg/ml	+ Pantoprazole sodium	4 mg/ml	+

Phloroglucinol

	10 mg/ml	+ Insulin	1 UI/ml	+
	0,4 mg/ml	+ Pantoprazole sodium	4 mg/ml	+

Phytomenadione

	0,2 mg/ml	+ Acetylsalicylic acid lysinate	10 mg/ml	+
	0,2 mg/ml	+ Pantoprazole sodium	4 mg/ml	+

Potassium chloride

	1340 mEq/l	+ Acetylsalicylic acid lysinate	10 mg/ml	+
	1340 mEq/l	+ Amiodarone hydrochloride	3 mg/ml	+

Pyridoxine hydrochloride

	0,5 mg/ml	+ Nefopam	0,16 mg/ml	+
	0,0025 mg/ml	+ Pantoprazole sodium	4 mg/ml	+

Remifentanil hydrochloride

100 µg/ml

Insulin

1 UI/ml

Spiramycine adipate

60 MUI/ml

Furosemide

10 mg/ml

Thiamine hydrochloride

1 mg/ml	+ Acetylsalicylic acid lysinate	10 mg/ml	+
2 mg/ml	+ Amiodarone hydrochloride	3 mg/ml	+
1 mg/ml	+ Atenolol	0,1 mg/ml	+
1 mg/ml	+ Clonidine hydrochloride	0,0125 mg/ml	+
0,5 mg/ml	+ Nefopam	0,16 mg/ml	+
1 mg/ml	+ Pantoprazole sodium	4 mg/ml	+

Tramadol hydrochloride

6,3 mg/ml

Nefopam

0,16 mg/ml

Urapidil

	5 mg/ml	+ Atenolol	0,1 mg/ml	+
	5 mg/ml	+ Clonidine hydrochloride	0,0125 mg/ml	+

Vancomycin hydrochloride

31,3 mg/ml

Amiodarone hydrochloride

9 mg/ml

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