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19/11/2024
止痛药   Morphine sulfate  
注射液
口服剂 药膏
溶液稳定性 混合物稳定性 影响稳定性的因素 兼容性 用药途径 引用文献 PDF
   化学式  

商品名   商品名     

商品名仅供参考, 药品所用的辅料可能依国家或厂商不同有所不同。

Dimor F 巴西
Duramorph 美国
Infumorph 美国
Miniject Morphine 英国
Morphine 加拿大
Morphine sulfate Lavoisier 法国
引用文献   注射液   引用文献 : Morphine sulfate  
种类 出版物
3 文献 Trissel LA, Martinez JF.
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6 文献 Trissel LA, Xu QA, Martinez JF, Fox JL.
Compatibility and stability of ondansetron hydrochloride with morphine sulfate and with hydromorphone hydrochloride in 0.9% sodium chloride injection at 4, 22 and 32°C.
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58 文献 Parker WA.
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59 文献 Trissel LA, Gilbert DL, Martinez JF, Kim MC.
Compatibility of remifentanil hydrochloride with selected drugs during simulated Y-site administration.
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62 文献 Pugh CB, Pabis DJ, Rodriguez C.
Visual compatibility of morphine sulfate and meperidine hydrochloride with other injectable drugs during simulated Y-site injection.
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64 文献 DiStefano JE, Outman WR.
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73 文献 Lor E, Takagi J.
Visual compatibility of foscarnet with other injectable drugs.
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81 文献 Trissel LA, Martinez JF.
Compatibility of piperacillin sodium plus tazobactam with selected drugs during simulated Y-site injection.
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84 文献 Trissel LA, Martinez JF.
Visual, turbidimetric, and particle-content assessment of compatibility of vinorelbine tartrate with selected drugs during simulated Y-site injection.
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86 文献 Johnson CE, Bhatt-Mehta V, Mancari SC, McKown JA.
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Compatibility of cefmetazole sodium with commonly used drugs during Y-site delivery.
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99 文献 Trissel LA, Martinez JF.
Compatibility of aztreonam with selected drugs during simulated Y-site administration.
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115 文献 Nahata MC, Morosco RS, Hipple TF.
Stability of morphine sulfate in bacteriostatic 0.9% sodium chloride injection stored in glass vials at two temperatures.
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116 文献 Stiles ML, Tu YH, Allen LV Jr.
Stability of morphine sulfate in portable pump reservoirs during storage and simulated administration.
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Visual compatibility of insulin with secondary intravenous drugs in admixtures.
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169 文献 Trissel LA, Martinez JF.
Physical compatibility of melphalan with selected drugs during simulated Y-site administration.
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182 文献 Trissel LA, Gilbert DL, Martinez JF.
Compatibility of granisetron hydrochloride with selected drugs during simulated Y-site administration.
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198 文献 Gayed AA, Kheshary PR, Hinkle RL.
Visual compatibility of diltiazem injection with various diluents and medications during simulated Y-site injection.
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199 文献 Hassan E, Leslie J, Martir-Herrero ML.
Stability of labetalol hydrochloride with selected critical care drugs during simulated Y-site injection.
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218 文献 Vogt C, Ruggaber S.
Compatibility of magnesium sulfate and morphine sulfate in 0.9% sodium chloride injection.
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220 文献 Johnson CE, Christen C, Perez MM, Ma M.
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221 文献 Neels JT.
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240 文献 Lam XM, Ward CA, de C du M?e CPR.
Stability and activity of alteplase with injectable drugs commonly used in cardiac therapy.
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244 文献 Trissel LA, Martinez JF.
Compatibility of filgrastim with selected drugs during simulated Y-site administration.
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248 文献 Trissel LA, Martinez JF.
Turbidimetric assessment of the compatibility of taxol with 42 other drugs during simulated Y-site injection.
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249 文献 Trissel LA, Martinez JF.
Compatibility of thiotepa (lyophilized) with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1996 ; 53: 1041-1045.
251 文献 Trissel LA, Gilbert DL, Martinez JF.
Compatibility of doxorubicin hydrochloride liposome injection with selected other drugs during simulated Y-site administration.
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253 文献 Trissel LA, Chandler SW, Folstad JT.
Visual compatibility of amsacrine with selected drugs during simulated Y-site injection.
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257 文献 Hunt-Fugate AK, Hennessey CK, Kazarian CM.
Stability of fluconazole in injectable solutions.
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266 文献 Patel PR.
Compatibility of meropenem with commonly used injectable drugs.
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295 文献 Yamashita SK, Walker SE, Choudhury T, Iazzetta J.
Compatibility of selected critical care drugs during Y-site administration.
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299 文献 Trissel LA, Martinez JF, Gilbert DL.
Compatibility of cisatracurium besylate with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 1735-1741.
300 文献 Trissel LA, Gilbert DL, Martinez JF.
Compatibility of propofol injectable emulsion with selected drugs during simulated Y-site administration.
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301 文献 Trissel LA, Gilbert DL, Martinez JF, Baker MB, Walter WV, Mirtallo JM.
Compatibility of parenteral nutrient solutions with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 1295-1300.
307 文献 Trissel LA, Martinez JF.
Compatibility of allopurinol sodium with selected drugs during simulated Y-site administration.
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314 文献 Chiu MF, Schwartz ML.
Visual compatibility of injectable drugs used in the intensive care unit.
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315 文献 Bahal SM, Lee TJ, McGinnes M, Dobler GL.
Visual compatibility of warfarin sodium injection with selected medications and solutions.
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316 文献 Veltri M, Lee CKK.
Compatibility of neonatal parenteral nutrient solutions with selected intravenous drugs.
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319 文献 Hadzija BW, Lubarsky DA.
Compatibility of etomidate, thiopental sodium, and propofol injections with drugs commonly administered during induction of anesthesia.
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334 文献 Trissel LA, Tramonte SM, Grilley BJ.
Visual compatibility of ondansetron hydrochloride with selected drugs during simulated Y-site injection.
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335 文献 Trissel LA, Bready BB, Kwan JW, Santiago NM.
Visual compatibility of sargramostim with selected antineoplasic agents, anti-infectives, or other drugs during simulated Y-site injection.
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336 文献 Forman JK, Lachs JR, Souney PF.
Visual compatibility of acyclovir sodium with commonly used intravenous drugs during simulated Y-site injection.
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337 文献 Bashaw ED, Amantea MA, Minor JR, Galleli JF.
Visual compatibility of zidovudine with other drugs during simulated Y-site administration.
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340 文献 Macias JM, Martin WJ, Lloyd CW.
Stability of morphine sulfate and meperidine hydrochloride in a parenteral nutrient formulation.
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341 文献 Baker DE, Yost GS, Craig VL, Campbell RK.
Compatibility of heparin sodium and morphine sulfate.
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386 文献 Colucci RD, Cobuzzi LE, Halpern NA.
Visual compatibility of labetalol hydrochloride injection with various injectable drugs during simulated Y-site injection.
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398 文献 Jay GT, Fanikos J, Souney PF.
Visual compatibility of famotidine with commonly used critical-care medications during simulated Y-site injection.
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Visual compatibility of neuromuscular blocking agents with various injectable drugs during simulated Y-site injection.
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Visual compatibility of midazolam hydrochloride with common preoperative injectable medications.
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513 文献 Xu QA, Trissel LA, Martinez JF.
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Stability of tacrolimus with morphine sulfate, hydromorphone hydrochloride, and ceftazidime during simulated intravenous coadministration.
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905 文献 Trissel LA, Martinez JF.
Screening teniposide for Y-site physical incompatibilities.
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921 文献 Trissel LA, Gilbert DL, Martinez JF.
Incompatibility and compatibility of amphotericin B cholesteryl sulfate complex with selected other drugs during simulated Y-site administration.
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Compatibility of morphine sulfate injection and prochlorperazine injection.
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Visual compatibility of dobutamine hydrochloride with other injectable drugs.
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Compatibility of verapamil hydrochloride injection with commonly used additives.
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Compatibility of levofloxacin with 34 medications during simulated Y-site administration.
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Incompatibility of morphine sulfate and prochlorperazine edisylate in syringes.
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Visual compatibility of foscarnet with other injectable drugs during simulated Y-site administration.
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Compatibility of various admixtures at Y-injection sites of intravenous administration sets. Part2.
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Stability of an intrathecal morphine injection formulation.
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1410 文献 Trissel LA, Martinez JF, Simmons M.
Compatibility of etoposide phosphate with selected drugs during simulated Y-site injection.
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1415 文献 Trissel L.A, Gilbert D.L, Martinez J.F, Baker M.B, Walter W.V, Mirtallo J.M.
Compatibility of medications with 3-in-1 parenteral nutrition admixtures.
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1423 文献 Trissel LA, Martinez JF, Gilbert DL.
Compatibility of gemcitabine hyrochloride with 107 selected drugs during simulated Y-site injection.
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Physical compatibility of pemetrexed disodium with other drugs during simulated Y-site administration.
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3152 文献 Kumar A, Mann HJ.
Visual compatibility of oritavancin diphosphate with selected coadministered drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2010 ; 67: 1640-1644.
3184 实验室
Hyaluronidase (Hyalase®) - Summary of Product characteristics.
CP Pharmaceuticals 2005
3249 文献 Singh BM, Dedhiya MG, Dinunzio J, Chan P, Kupiec TC, Trissel LA, Laudano JB.
Compatibility of ceftaroline fosamil for injection with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2011 ; 68: 2163-2169.
3279 文献 Al-Tannak N.F, Cable C.G, McArthur D.A, Watson D.G
A stability indicating assay for a combination of morphine sulphate with levomepromazine hydrochloride used in palliative care.
J Clin Pharm Ther 2012 ; 37, 1: 71-73.
3434 文献 Kistner C, Ensom M.H.H, Decarie D, Lauder G, Carr R.R.
Compatibility and Stability of Morphine Sulphate and Naloxone Hydrochloride in 0.9% Sodium Chloride for Injection.
Can J Hosp Pharm 2013 ; 66, 3 : 167-170.
3474 实验室 Fluorouracil - Summary of Product Characteristics
Accord Healthcare Limited 2009
3504 实验室 Parecoxib (Dynastat®) - Summary of Product Characteristics
Pfizer 2012
3507 实验室 Chirocaine - Summary of Product Characteristics
AbbVie 2013
3525 实验室 Pethidine hydrochloride - Summary of product Characteristics
AMCO Amdipharm Mercury 2012
3531 实验室 Morphine sulphate 10 mg/mL injection BP – Summary of Product Characteristics
Wockhardt 2014
3571 文献 Anderson C, Boehme S, Ouellette J, Stidham C, MacKay M.
Physical and Chemical Compatibility of Injectable Acetaminophen During Simulated Y-Site Administration.
Hosp Pharm 2014 ; 49, 1: 42-47.
3578 实验室 Cisplatin - Summary of Product Characteristics
Accord Healthcare 2011
3593 实验室 Ketorolac trometamol (Ketorolac®) - Summary of Product Characteristics
Beacon Pharmaceuticals 2011
3595 实验室 Aciclovir - Summary of Product Characteristics
Hospira 2009
3599 实验室 Glycopyrrolate Injection U.S.P. - Summary of Product Characteristics
Amco Amdipharm Mercry 2013
3644 实验室 Calcium gluconate® - Summary of Product Characteristics
Hameln Pharmaceuticals 2010
3675 实验室 Thiopental sodium - Summary of Product Characteristics
Archimedes Pharma UK Ltd 2015
3824 文献 Boudi S, Roy H, Forest JM, Leclair G.
Compatibilité physique de l'association amoxicilline-acide clavulanique en injection avec plusieurs autres médicaments lors d'une administration en Y.
Pharmactuel 2023 2023;56,3:91-98
3828 海报 Thabit A.K, Hamada Y, Nicolau D.P.
Ceftozolane/tazobactam physical compatibility during simulated Y-site administration.
ASHP Midyear 2015
3829 海报 So W, Kim L, Thabit A.K, Nicolau D.P, Kuti J.L.
Compatibility of isavunazonium sulfate during simulated Y-site administration.
ASHP Midyear 2015
3934 实验室 Eptifibatide (Integrilin®) - Résumé des caractéristiques du produit
GlaxoSmithKline Laboratoire 2016
3948 文献 Bouchoud L, Fonzo-Christe C, Klingm?ller M, Bonnabry P .
Compatibility of Intravenous Medications With Parenteral Nutrition - In Vitro Evaluation.
JPEN 2012 ;30. 416?424.
3964 文献 Audet M.A, Forest E, Friciu M, Forest J.M, Leclair G.
Compatibilité du citrate de caféine injectable avec plusieurs autres médicaments.
Pharmactuel 2017 ; 50,1 : 27-33.
3998 文献 Robert J, Sorrieul J, Rossignol E, Beaussart H, Kieffer H, Folliard C, Dupoiron D, Devys C.
Chemical Stability of Morphine, Ropivacaine, and Ziconotide in Combination for Intrathecal Analgesia.
Int J Pharm Compound 2017 ; 21:4 :347-351
4051 文献 Robert J, Sorrieul J, Kieffer H, Folliard C, Gibory V, Dupoiron D, Devys C.
Stability study of morphine and baclofen solution in polypropylene syringes.
Pharmaceutical Technology in Hospital Pharmacy 2017 ;2,4:173-180
4055 文献 Monogue M, Almarzoky Abuhussain S, Kuti J, Nicolau D.
Physical compatibility of fosfomycin for injection with select i.v. drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2018 , 75, 1:36-44
4145 文献 Asempa T.E, Avery L.M, Kidd J.M, Kuti J.L, Nicolau D.P.
Physical compatibility of plazomicin with select i.v. drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2018 ;75,14:1048-1056
4303 文献 Anderson C, MacKay M.
Stability of Fentanyl Citrate, Hydromorphone Hydrochloride, Ketamine Hydrochloride, Midazolam, Morphine Sulfate, and Pentobarbital Sodium in Polypropylene Syringes.
Pharmacy 2015 3, 379-385.
4319 文献 Lessard J-J, Caron E, Schérer H, Forest J-M, Leclair G.
Compatibility of Y-site Injection of Meropenem Trihydrate With 101 Other Injectable Drugs.
Hosp Pharm 2020 ; 55, 5: 332-337.
4380 实验室 Posaconazole (Noxafil®) - Summary of Product Characteristics
Merck Sharp & Dohme Limited 2019
4389 文献 Côté K, Correal F, Metras M.E, Friciu M, Forest J.M, Leclair G.
Compatibilité physique des médicaments administrés en Y aux soins intensifs, en particulier la dexmédétomidine, le lévosimendan et la kétamine.
Pharmactuel 2019 ;52,4:206-213
4395 海报 Hook R, Riss V, Neault A, Ma N, Law S, Walker S.E.
Stability of Morphine Solutions of 20, 40, 100 , 200 and 1,000 µg/mL in Syringes Following Dilution with 0.9% Sodium Chloride or D5W at Room Temperature (25°C).
Sunnybrook Health Sciences Centre 2020
4419 文献 Holt R.J, Siegert S.W.K, Krishna A.
Physical Compatibility of Ibuprofen Lysine Injection with Selected Drugs During Simulated Y-site Injection.
J Pediatr Pharmacol Ther 2008 ; 13, 3: 155-161.
4434 文献 Avery L.M, Chen, I.H, Reyes, S, Nicolau, D.P, Kuti J.L.
Assessment of the Physical Compatibility of Eravacycline and Common Parenteral Drugs During Simulated Y-site Administration.
Clin Ther 2019 ; 41, 10: 2162-2170.
4496 文献 Sorrieul J, Robert J, Dupoiron D, Devys, C.
Stability Study of Admixtures Combining Ziconotide With Morphine or Sufentanil in Polypropylene Syringes.
Neuromodulation 2020 ; 24, 7: 1145-1156.
4528 文献 Lu J, Liu Q, Kupiec T, Vail H, Lunch L, Fam D, Vu N.
Physical Compatibility of Cefiderocol with Selected Intravenous Drugs During Simulated Y-site Administration.
Int J Pharm Compound 2021 ;25,1:52-61
4538 文献 Campbell A, Petrovski M, Senarathna G, Mukadam ,Strunk T, Batty K.
Compatibility of pentoxifylline and parenteral medications.
Archives of Disease in Childhood 2020 ; 105: 395-397.
4543 文献 Senarathna G, Strunk T, Petrovski M, Batty K.
Physical compatibility of pentoxifylline and intravenous medications.
Archives of Disease in Childhood 2018 ;104:292–295.
4603 文献 Vallée M, Barthélémy I, Friciu M, Pelletier E, Forest J.M, Benoit F, Leclair G.
Compatibility of Lactated Ringer’s Injection With 94 Selected Intravenous Drugs During Simulated Y-site Administration.
Hosp Pharm 2021 ; 56, 4: 228-234.
4650 实验室 Ceftobiprole (Zevtera 500 mg powder for concentrate for solution for infusion.) Summary of Product Characteristics, Advanz Pharma updated 4 aug 2021.
Advanz Pharma 2021
4669 文献 Robert J, Sorrieul J, Dupoiron D, Jubier-Hamon S, Bienfait F, Visbecq A, Devys C.
Physicochemical Stability Study of the Morphine-Ropivacaine-Ziconotide Association in Implantable Pumps for Intrathecal Administration.
Neuromodulation 2021 : 1-16.
4730 文献 Sorrieul J, Robert J, Vincent L, Andre M, Bourcier B, Bienfait F, Jubier Hamon S, Dupoiron D, Devys C.
Stability of Morphine Sulfate-Clonidine and Sufentanil-Clonidine Mixtures.
Neuromodulation 2022
4742 文献 Macoviciuc M, Nguyen C, Forest J-M, Leclair G.
Compatibilité physique de l’acétaminophène injectable avec 102 autres médicaments lors d’une administration en Y.
Pharmactuel 2022 ; 55, 4: 247-255.
4801 文献 Ruiz V, Yuwei Shen Y, Abouelhassan Y, Fouad A, Nicolau D, Kuti J.
Physical compatibility of sulbactam/durlobactam with select intravenous drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2024 ;51,1:
4837 文献 De Silva, D.T.N Petrovski M, Strunk T, Mukadam N, Page‑Sharp N, Moore B.R, Batty K.T.
Physicochemical compatibility of caffeine citrate and caffeine base injections with parenteral medications used in neonatal intensive care settings.
Eur J Clin Pharmacol 2024 ; 80:1079–1087.

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