Last update :
23/11/2022
References   References 4669  
Type : Journal
Web link : https://doi.org/10.1016/j.neurom.2021.10.002

Research teams : Angers - Institut de cancérologie de l’ouest - Paul Papin, Pharmacy Department
Authors : Robert J, Sorrieul J, Dupoiron D, Jubier-Hamon S, Bienfait F, Visbecq A, Devys C.
Title : Physicochemical Stability Study of the Morphine-Ropivacaine-Ziconotide Association in Implantable Pumps for Intrathecal Administration.
Reference : Neuromodulation : 1-16. 2021

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionMorphine sulfate Analgesic
InjectionRopivacain hydrochloride Local anesthetic
InjectionZiconotide acetate Analgesic
Stability of mixtures
Synchromed® Sodium chloride 0,9% 37°C Protect from light
Injection Morphine sulfate 0,5 mg/ml
Injection Ropivacain hydrochloride 0,5 mg/ml
Injection Ziconotide acetate 0,5 µg/ml
14 Day
Synchromed® Sodium chloride 0,9% 37°C Protect from light
Injection Morphine sulfate 6 mg/ml
Injection Ropivacain hydrochloride 8,5 mg/ml
Injection Ziconotide acetate 0,5 µg/ml
21 Day
Synchromed® Sodium chloride 0,9% 37°C Protect from light
Injection Morphine sulfate 0,5 mg/ml
Injection Ropivacain hydrochloride 8,5 mg/ml
Injection Ziconotide acetate 0,5 µg/ml
60 Day
Synchromed® Sodium chloride 0,9% 37°C Protect from light
Injection Morphine sulfate 0,5 mg/ml
Injection Ropivacain hydrochloride 0,5 mg/ml
Injection Ziconotide acetate 2 µg/ml
60 Day

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