Last update :
19/04/2021
References   References 4496  
Type : Journal
Web link : 10.1111/ner.13289

Research teams : Angers - Institut de cancérologie de l’ouest - Paul Papin, Pharmacy Department
Authors : Sorrieul J, Robert J, Dupoiron D, Devys, C.
Title : Stability Study of Admixtures Combining Ziconotide With Morphine or Sufentanil in Polypropylene Syringes.
Reference : Neuromodulation 2020

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionMorphine sulfate Analgesic
InjectionSufentanil citrate Analgesic
InjectionZiconotide acetate Analgesic
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 2-8°C Not specified
Injection Ziconotide acetate 0,2 >> 3 µg/ml
Injection Sufentanil citrate 0,003 >>0,045 mg/ml
7 Day
Polypropylen Syringe Sodium chloride 0,9% 2-8°C Not specified
Injection Morphine sulfate 0,5 >> 30 mg/ml
Injection Ziconotide acetate 0,2 >> 3 µg/ml
7 Day

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