Last update :
10/07/2024
References   References 4730  
Type : Journal
Web link : https://doi.org/10.1016/j.neurom.2022.07.008

Research teams : Angers - Institut de cancérologie de l’ouest - Paul Papin, Pharmacy Department
Authors : Sorrieul J, Robert J, Vincent L, Andre M, Bourcier B, Bienfait F, Jubier Hamon S, Dupoiron D, Devys C.
Title : Stability of Morphine Sulfate-Clonidine and Sufentanil-Clonidine Mixtures.
Reference : Neuromodulation 2022

Level of Evidence : 
Level of evidence A+
Physical stability : 
Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
injectionClonidine hydrochloride Antihypertensive
injectionMorphine sulfate Analgesic
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 2-8°C Protect from light
injection Morphine sulfate 1 mg/ml
injection Clonidine hydrochloride 0,001 mg/ml
5 Day
Polypropylen Syringe Sodium chloride 0,9% 2-8°C Protect from light
injection Morphine sulfate 1 mg/ml
injection Clonidine hydrochloride 0,02 mg/ml
5 Day
Polypropylen Syringe Sodium chloride 0,9% 2-8°C Protect from light
injection Morphine sulfate 10 mg/ml
injection Clonidine hydrochloride 0,02 mg/ml
5 Day
Polypropylen Syringe Sodium chloride 0,9% 23-27°C Protect from light
injection Morphine sulfate 1 mg/ml
injection Clonidine hydrochloride 0,02 mg/ml
5 Day
Polypropylen Syringe Sodium chloride 0,9% 23-27°C Protect from light
injection Morphine sulfate 1 mg/ml
injection Clonidine hydrochloride 0,001 mg/ml
5 Day
Polypropylen Syringe Sodium chloride 0,9% 23-27°C Protect from light
injection Morphine sulfate 10 mg/ml
injection Clonidine hydrochloride 0,02 mg/ml
5 Day
Synchromed® Sodium chloride 0,9% 37°C Protect from light
injection Morphine sulfate 10 mg/ml
injection Clonidine hydrochloride 0,02 mg/ml
28 Day
Synchromed® Sodium chloride 0,9% 37°C Protect from light
injection Morphine sulfate 1 mg/ml
injection Clonidine hydrochloride 0,001 mg/ml
28 Day

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