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07/04/2025
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Sympathomimetic   Epinephrine hydrochloride  
injection
Ointments
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Adrenalin Canada, Denmark, Finland, Germany, Iceland, Luxembourg, Norway, Spain, Sweden, Switzerland, Turkey
Adrenalina Argentina, Brazil, Colombia, Ecuador, Italy, Portugal, Romania, Spain
Adrenaline Australia, Austria, Belgium, Egypt, France, New Zealand, Saudi Arabia, United Arab Emirates
Anapen Austria, Canada, Egypt, France, Germany, Great Britain, Netherlands, Sweden, Switzerland
Emerade Croatia, Denmark, Finland, France, Germany, Great Britain, Italy, Norway, Spain, Sweden
Epipen Argentina, Austria, Belgium, Canada, Chile, Croatia, Denmark, Finland, France, Germany, Great Britain, Hungary, Iceland, Iran, Ireland, Japan, Malaysia, Netherlands, New Zealand, Norway, Romania, Slovenia, Sweden, Switzerland, United States of America
Levophed Belgium, Canada, Greece, Luxembourg, New Zealand, Saudi Arabia, United Arab Emirates, United States of America
Levopress Venezuela
Pinadrina Mexico
Suprarenin Austria, Finland, Germany
Tonogen Hungary, Italy
Vasocon Belgium, Brazil, Chile, France, India, Luxembourg, Malaysia, Spain, United States of America
Compatibility   injection   Compatibility : Epinephrine hydrochloride              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
injection Epinephrine hydrochloride 30 µg/ml
Plasmalyte 148 dextrose 5% (Baxter) 4835
Compatible
injection Epinephrine hydrochloride 200 µg/ml
Parenteral nutrition (binary mixture) 939
Compatible
injection Epinephrine hydrochloride 0,2 µg/ml
injection Alprostadil 20 µg/ml
Glucose 5% 4491
Compatible
injection Epinephrine hydrochloride 200 µg/ml
injection Alprostadil 20 µg/ml
Glucose 5% 4651
Compatible
injection Epinephrine hydrochloride 1000 µg/ml
injection Amiodarone hydrochloride 6 mg/ml
Glucose 5% 1611
Compatible
injection Epinephrine hydrochloride 1000 µg/ml
injection Amoxicillin sodium / clavulanic acid 100/10 mg/ml
3824
Compatible
injection Epinephrine hydrochloride
injection Angiotensin II
Sodium chloride 0,9% 4818
Compatible
injection Epinephrine hydrochloride 50 µg/ml
injection Anidulafungin 0.5 mg/ml
Glucose 5% 1982
Compatible
injection Epinephrine hydrochloride 4 µg/ml
injection Atracurium besylate 0.5 mg/ml
Glucose 5% 402
Compatible
injection Epinephrine hydrochloride 50 µg/ml
injection Bivalirudin 5 mg/ml
Glucose 5% 1713
Compatible
injection Epinephrine hydrochloride 64 µg/ml
injection Caffeine 10 mg/ml
Glucose 5% 4837
Compatible
injection Epinephrine hydrochloride 100 µg/ml
injection Caffeine 10 mg/ml
None 3964
Compatible
injection Epinephrine hydrochloride 64 µg/ml
injection Caffeine citrate 20 mg/ml
Glucose 5% 4837
Compatible
injection Epinephrine hydrochloride 32 µg/ml
injection Calcium chloride 4 mg/ml
Sodium chloride 0,9% 3622
Compatible
injection Epinephrine hydrochloride 0.064 µg/ml
injection Calcium chloride 20 mg/ml
Glucose 5% 4732
Compatible
injection Epinephrine hydrochloride 0.032 µg/ml
injection Calcium chloride 20 mg/ml
Glucose 5% 4732
Compatible
injection Epinephrine hydrochloride 0,05 µg/ml
injection Caspofungin acetate 0,7 mg/ml
Sodium chloride 0,9% 2247
Compatible
injection Epinephrine hydrochloride 16 µg/ml
injection Cefiderocol sulfate tosylate 20 mg/mL
NaCl 0,9% or Glucose 5% 4528
Compatible
injection Epinephrine hydrochloride 100 µg/ml
injection Cefpirome sulfate 50 mg/ml
NaCl 0,9% or Glucose 5% 280
Compatible
injection Epinephrine hydrochloride 100 µg/ml
injection Cefpirome sulfate 50 mg/ml
Ringer’s lactate solution 280
Compatible
injection Epinephrine hydrochloride 100 µg/ml
injection Cefpirome sulfate 50 mg/ml
Sodium chloride 0,45% 280
Compatible
injection Epinephrine hydrochloride 50 µg/ml
injection Ceftazidime 125 mg/ml
Water for Injection 2141
Compatible
injection Epinephrine hydrochloride 16 µg/ml
injection Ceftolozane / tazobactam 10/5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
injection Epinephrine hydrochloride 0.1 µg/ml
injection Cimetidine hydrochloride 3 mg/ml
Glucose 5% 1201
Compatible
injection Epinephrine hydrochloride 50 µg/ml
injection Cisatracurium besylate 0.1 >> 5 mg/ml
Glucose 5% 299
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Clonidine hydrochloride 0,018 mg/ml
Sodium chloride 0,9% 2018
Compatible
injection Epinephrine hydrochloride 100 µg/ml
injection Cloxacillin sodium 100 mg/ml
Water for Injection 3012
Compatible
injection Epinephrine hydrochloride 1000 µg/ml
injection Cloxacillin sodium 100 mg/ml
Water for Injection 3012
Compatible
injection Epinephrine hydrochloride 50 µg/ml
injection Dexmedetomidine 4 µg/ml
Sodium chloride 0,9% 1712
Compatible
injection Epinephrine hydrochloride 1000 µg/ml
injection Diatrizoate meglumine 283 mg/ml
None 1085
Compatible
injection Epinephrine hydrochloride 50 µg/ml
injection Diltiazem hydrochloride 1 & 5 mg/ml
Sodium chloride 0,9% 198
Compatible
injection Epinephrine hydrochloride 4 µg/ml
injection Diltiazem hydrochloride 5 mg/ml
Sodium chloride 0,9% 198
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Diltiazem hydrochloride 1 mg/ml
314
Compatible
injection Epinephrine hydrochloride 0.1 µg/ml
injection Dobutamine hydrochloride 2 mg/ml
Glucose 5% 1041
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Dobutamine hydrochloride 4 mg/ml
314
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Dopamine hydrochloride 3.2 mg/ml
314
Compatible
injection Epinephrine hydrochloride 16 µg/ml
injection Eravacycline 0,6 mg/ml
Sodium chloride 0,9% 4434
Compatible
injection Epinephrine hydrochloride 128 µg/ml
injection Esmolol hydrochloride 10 mg/ml
Sodium chloride 0,9% 3879
Compatible
injection Epinephrine hydrochloride 40 µg/ml
injection Esomeprazole sodium 0.32 mg/ml
NaCl 0,9% or Glucose 5% 1506
Compatible
injection Epinephrine hydrochloride 4 µg/ml
injection Famotidine 0.2 mg/ml
Glucose 5% 398
Compatible
injection Epinephrine hydrochloride 50 µg/ml
injection Fenoldopam mesylate 80 µg/ml
Sodium chloride 0,9% 1803
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Fentanyl citrate 50 µg/ml
314
Compatible
injection Epinephrine hydrochloride 8 µg/ml
injection Flucloxacillin sodium 20 mg/ml
Water for Injection 1232
Compatible
injection Epinephrine hydrochloride 16 µg/ml
injection Fosfomycin 30 mg/ml
NaCl 0,9% or Glucose 5% 4055
Compatible
injection Epinephrine hydrochloride 16 & 100 µg/ml
injection Furosemide 1 mg/ml
Sodium chloride 0,9% 4570
Compatible
injection Epinephrine hydrochloride 16 & 100 µg/ml
injection Furosemide 10 mg/ml
Sodium chloride 0,9% 4570
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Furosemide 10 mg/ml
314
Compatible
injection Epinephrine hydrochloride 200 µg/ml
injection Furosemide 10 mg/ml
None 3210
Compatible
injection Epinephrine hydrochloride 8 µg/ml
injection Furosemide 1 mg/ml
Water for Injection 1232
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Heparin sodium 100 UI/ml
314
Compatible
injection Epinephrine hydrochloride 100 µg/ml
injection Heparin sodium 1 UI/ml
NaCl 0,9% or Glucose 5% 1228
Compatible
injection Epinephrine hydrochloride 100 µg/ml
injection Heparin sodium 1 UI/ml
Ringer’s lactate solution 1228
Compatible
injection Epinephrine hydrochloride 50 µg/ml
injection Hetastarch 60 mg/ml
specific solvent 1721
Unspecified incompatibility Incompatible
injection Epinephrine hydrochloride
injection Hyaluronidase
3184
Unspecified incompatibility Incompatible
injection Epinephrine hydrochloride
injection Hyaluronidase
3617
Compatible
injection Epinephrine hydrochloride 100 µg/ml
injection Hydrocortisone sodium succinate 1 mg/ml
NaCl 0,9% or Glucose 5% 1228
Compatible
injection Epinephrine hydrochloride 100 µg/ml
injection Hydrocortisone sodium succinate 1 mg/ml
Ringer’s lactate solution 1228
Compatible
injection Epinephrine hydrochloride 128 µg/ml
injection Hydrocortisone sodium succinate 1 mg/ml
Sodium chloride 0,9% 4465
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Hydromorphone hydrochloride 1 mg/ml
314
Chemical instability Incompatible
injection Epinephrine hydrochloride
injection Hydroxocobalamin
3932
Compatible
injection Epinephrine hydrochloride 8 >> 100 µg/ml
injection Ibuprofen lysinate 10 mg/ml
Water for Injection 4419
Compatible
injection Epinephrine hydrochloride 50 µg/ml
injection Imipenem-Cilastatin / Relebactam 5 mg/ml
NaCl 0,9% or Glucose 5% 4433
Compatible
injection Epinephrine hydrochloride
injection Imipenem-Cilastatin / Relebactam
4809
Compatible
injection Epinephrine hydrochloride 60 & 300 µg/ml
injection Insulin aspart 1 UI/ml
NaCl 0,9% or Glucose 5% 1508
Compatible
injection Epinephrine hydrochloride 1000 µg/ml
injection Iohexol 300 mg I/ml
None 1085
Compatible
injection Epinephrine hydrochloride 16 µg/ml
injection Isavuconazonium sulfate 1.5 mg/ml
NaCl 0,9% or Glucose 5% 3829
Compatible
injection Epinephrine hydrochloride 1000 µg/ml
injection Levofloxacine 5 mg/ml
Glucose 5% 1072
Compatible
injection Epinephrine hydrochloride 128 µg/ml
injection Metoprolol tartrate 0.4 mg/ml
Sodium chloride 0,9% 3879
Compatible
injection Epinephrine hydrochloride 30 µg/ml
Plasmalyte 148 (Baxter) 4835
Compatible
injection Epinephrine hydrochloride 1000 µg/ml
injection Ioxaglate 320 mg I/ml
None 1085
Unspecified incompatibility Incompatible
injection Epinephrine hydrochloride
injection Iron (polymaltose)
3642
Unspecified incompatibility Incompatible
injection Epinephrine hydrochloride
injection Iron dextran
3642
Compatible
injection Epinephrine hydrochloride 16>>>32 µg/ml
Normosol® 4655
Compatible
injection Epinephrine hydrochloride 1000 µg/ml
injection Ketamine hydrochloride 50 mg/ml
2109
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Labetalol hydrochloride 2 mg/ml
314
Compatible
injection Epinephrine hydrochloride 128 µg/ml
injection Labetalol hydrochloride 5 mg/ml
Sodium chloride 0,9% 3879
Compatible
injection Epinephrine hydrochloride 1000 µg/ml
injection Levosimendan 2,5 mg/ml
4389
Compatible
injection Epinephrine hydrochloride 9 µg/ml
injection Lidocaine hydrochloride 9 & 18 mg/ml
NaHCO3 2878
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Lorazepam 0.5 mg/ml
314
Compatible
injection Epinephrine hydrochloride 1000 µg/ml
injection Meropenem 50 mg/ml
Water for Injection 4319
Precipitation after 4 hours Incompatible
injection Epinephrine hydrochloride 50 µg/ml
injection Micafungin 1.5 mg/ml
Sodium chloride 0,9% 2108
Compatible
injection Epinephrine hydrochloride 32 µg/ml
injection Milrinone lactate 1 mg/ml
4506
Compatible
injection Epinephrine hydrochloride 128 µg/ml
injection Milrinone lactate 0.8 mg/ml
Glucose 5% 813
Compatible
injection Epinephrine hydrochloride 9.6 µg/ml
Parenteral nutrition (binary mixture) 3379
Unspecified incompatibility Incompatible
injection Epinephrine hydrochloride
NaHCO3 3642
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Midazolam hydrochloride 2 mg/ml
314
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Milrinone lactate 0.2 mg/ml
314
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Morphine sulfate 2 mg/ml
314
Unspecified incompatibility Incompatible
injection Epinephrine hydrochloride 1000 µg/ml
injection N-acetylcysteine 200 mg/ml
None 3766
Compatible
injection Epinephrine hydrochloride 1000 µg/ml
injection Naloxone hydrochloride 0.4 mg/ml
None 3408
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Nicardipine hydrochloride 1 mg/ml
314
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Nitroglycerin 0.4 mg/ml
314
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Norepinephrine bitartrate 0.128 mg/ml
314
Compatible
injection Epinephrine hydrochloride 40 µg/ml
injection Oritavancin 0.8 >>2 mg/ml
Glucose 5% 3152
Chemical instability Incompatible
injection Epinephrine hydrochloride 1 & 10 µg/ml
NaHCO3 2077
Compatible
injection Epinephrine hydrochloride 4 µg/ml
injection Pancuronium bromide 0.05 mg/ml
Glucose 5% 402
Compatible
injection Epinephrine hydrochloride 16 >> 32 µg/ml
injection Pantoprazole sodium 0.16 >> 0.8 mg/ml
Sodium chloride 0,9% 1902
Immediate precipitation Incompatible
injection Epinephrine hydrochloride
injection Pantoprazole sodium
2090
Compatible
injection Epinephrine hydrochloride 1 µg/ml
injection Paracetamol 10 mg/ml
4742
Compatible
injection Epinephrine hydrochloride 12 µg/ml
injection Pentoxifyllin 5 mg/ml
Sodium chloride 0,9% 4543
Compatible
injection Epinephrine hydrochloride 16 µg/ml
injection Plazomicin sulfate 24 mg/ml
Sodium chloride 0,9% 4145
Compatible
injection Epinephrine hydrochloride 100 µg/ml
injection Potassium chloride 40 mEq/l
NaCl 0,9% or Glucose 5% 1228
Compatible
injection Epinephrine hydrochloride 100 µg/ml
injection Potassium chloride 40 mEq/l
Ringer’s lactate solution 1228
Compatible
injection Epinephrine hydrochloride 100 µg/ml
injection Propofol 10 mg/ml
None 300
Instability of the emulsion after 6 hours Incompatible
injection Epinephrine hydrochloride 0.1 µg/ml
injection Propofol
660
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Ranitidine hydrochloride 1 mg/ml
314
Compatible
injection Epinephrine hydrochloride 50 µg/ml
injection Remifentanil hydrochloride 25 & 250 µg/ml
Sodium chloride 0,9% 59
Compatible
injection Epinephrine hydrochloride 64 µg/ml
injection Sildenafil citrate 0,6 mg/ml
Glucose 5% 4845
Chemical instability Incompatible
injection Epinephrine hydrochloride 1 & 10 µg/ml
injection Sodium bicarbonate 84 mg/ml
None 2077
Chemical instability Incompatible
injection Epinephrine hydrochloride
injection Sodium bicarbonate
3086
Compatible
injection Epinephrine hydrochloride 1000 µg/ml
injection Sugammadex 100 mg/ml
None 3372
Compatible
injection Epinephrine hydrochloride 0,016 µg/ml
injection Sulbactam/durlobactam 15/15 mg/ml
Sodium chloride 0,9% 4801
Compatible
injection Epinephrine hydrochloride 16 µg/ml
injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3827
Compatible
injection Epinephrine hydrochloride 50 µg/ml
injection Temocilline 83.33 mg/ml
Water for Injection 2231
Color change after 4 hours Incompatible
injection Epinephrine hydrochloride 20 µg/ml
injection Thiopental sodium 25 mg/ml
314
Compatible
injection Epinephrine hydrochloride 1000 µg/ml
Ringer’s lactate solution 4603
Compatible
injection Epinephrine hydrochloride 2 & 100 µg/ml
injection Tirofiban 50 µg/ml
NaCl 0,9% or Glucose 5% 1603
Compatible
injection Epinephrine hydrochloride
injection Tirofiban
1512
Compatible
injection Epinephrine hydrochloride 50 µg/ml
injection Vancomycin hydrochloride 10 mg/ml
Glucose 5% 3385
Compatible
injection Epinephrine hydrochloride 4 µg/ml
injection Vasopressin 2 & 4 UI/ml
Sodium chloride 0,9% 1801
Compatible
injection Epinephrine hydrochloride 4 µg/ml
injection Vecuronium bromide 0.1 mg/ml
Glucose 5% 402
Compatible
injection Epinephrine hydrochloride 20 µg/ml
injection Vecuronium bromide 1 mg/ml
314
Compatible
injection Epinephrine hydrochloride 2 µg/ml
injection Verapamil hydrochloride 0.08 mg/ml
NaCl 0,9% or Glucose 5% 1057
Compatible
injection Epinephrine hydrochloride 100 µg/ml
injection Warfarin sodium 0.1 & 2 mg/ml
NaCl 0,9% or Glucose 5% 552
  Mentions Légales