Last update :
16/06/2024
References   References 4758  
Type : Journal
Web link : https://doi.org/10.2174/1573412919666230315151351

Research teams : Porto Alegre - Pharmacy School of Federal University of Rio Grande do Sul
Authors : Schmidt J.P, Steppe M.
Title : Stability Study and Simultaneous Determination of Norepinephrine, Moxifloxacin, and Piperacillin + Tazobactam Mixtures Applied in Intensive Care Medicine .
Reference : Curr Pharm Anal ; 19, 4: 307-316. 2023

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionMoxifloxacin Antibiotic
Stability in solutions Not specified Glucose 5% 1,6 mg/ml 22-23°C Protect from light
24 Hour
InjectionNorepinephrine bitartrate Sympathomimetic
Stability in solutions Not specified Sodium chloride 0,9% 0,064 mg/ml 22-23°C Protect from light
24 Hour
InjectionPiperacillin sodium / tazobactam Antibiotic
Stability in solutions Not specified Sodium chloride 0,9% 40 / 5 mg/ml 22-23°C Protect from light
24 Hour
Stability of mixtures
Polypropylene Sodium chloride 0,9% 22-23°C Protect from light
Injection Norepinephrine bitartrate 0,032 mg/ml
Injection Piperacillin sodium / tazobactam 20 / 2.5 mg/ml
24 Hour
Polypropylene NaCl 0,45% Glucose 2,5% 22-23°C Protect from light
Injection Norepinephrine bitartrate 0,032 mg/ml
Injection Moxifloxacin 8 mg/ml
24 Hour

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