Last update :
19/11/2024
References   References 3824  
Type : Journal

Research teams : Montreal - Faculté de pharmacie, Université de Montréal
Authors : Boudi S, Roy H, Forest JM, Leclair G.
Title : Compatibilité physique de l'association amoxicilline-acide clavulanique en injection avec plusieurs autres médicaments lors d'une administration en Y.
Reference : Pharmactuel 2023;56,3:91-98 2023

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAciclovir sodium Antiviral
Incompatible 50 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionAmikacin sulfate Antibiotic
Compatible 250 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionAminophylline Various
Compatible 25 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionAmiodarone hydrochloride Anti-arrhythmic
Incompatible 50 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionAmoxicillin sodium / clavulanic acid Antibiotic
Incompatible 100/10 mg/ml + injectionAciclovir sodium 50 mg/ml
Compatible 100/10 mg/ml + injectionAmikacin sulfate 250 mg/ml
Compatible 100/10 mg/ml + injectionAminophylline 25 mg/ml
Incompatible 100/10 mg/ml + injectionAmiodarone hydrochloride 50 mg/ml
Compatible 100/10 mg/ml + injectionAmphotericin B liposomale 2 mg/ml
Compatible 100/10 mg/ml + injectionAmpicillin sodium 100 mg/ml
Compatible 100/10 mg/ml + injectionAtropine sulfate 0,4 mg/ml
Compatible 100/10 mg/ml + injectionAzithromycine 100 mg/ml
Compatible 100/10 mg/ml + injectionCalcium chloride 100 mg/ml
Compatible 100/10 mg/ml + injectionCalcium gluconate 100 mg/ml
Compatible 100/10 mg/ml + injectionCefazolin sodium 100 mg/ml
Compatible 100/10 mg/ml + injectionCefotaxime sodium 100 mg/ml
Compatible 100/10 mg/ml + injectionCefoxitin sodium 100 mg/ml
Compatible 100/10 mg/ml + injectionCeftazidime 100 mg/ml
Compatible 100/10 mg/ml + injectionCeftriaxone disodium 100 mg/ml
Compatible 100/10 mg/ml + injectionCefuroxime sodium 100 mg/ml
Incompatible 100/10 mg/ml + injectionCiclosporin 50 mg/ml
Compatible 100/10 mg/ml + injectionCiprofloxacin lactate 2 mg/ml
Incompatible 100/10 mg/ml + injectionClindamycin phosphate 150 mg/ml
Compatible 100/10 mg/ml + injectionCloxacillin sodium 100 mg/ml
Compatible 100/10 mg/ml + injectionCo-trimoxazole 16/80 mg/ml
Compatible 100/10 mg/ml + injectionDexamethasone sodium phosphate 4 mg/ml
Compatible 100/10 mg/ml + injectionDexmedetomidine 100 µg/ml
Compatible 100/10 mg/ml + injectionDiazepam 5 mg/ml
Compatible 100/10 mg/ml + injectionDigoxin 250 µg/ml
Compatible 100/10 mg/ml + injectionDimenhydrinate 10 mg/ml
Incompatible 100/10 mg/ml + injectionDiphenhydramine hydrochloride 50 mg/ml
Incompatible 100/10 mg/ml + injectionDobutamine hydrochloride 12,5 mg/ml
Compatible 100/10 mg/ml + injectionDopamine hydrochloride 3,2 mg/ml
Compatible 100/10 mg/ml + injectionEnalaprilate 1,25 mg/ml
Compatible 100/10 mg/ml + injectionEpinephrine hydrochloride 1000 µg/ml
Compatible 100/10 mg/ml + injectionErtapenem 100 mg/ml
Incompatible 100/10 mg/ml + injectionErythromycin lactobionate 50 mg/ml
Compatible 100/10 mg/ml + injectionEsmolol hydrochloride 10 mg/ml
Compatible 100/10 mg/ml + injectionFamotidine 10 mg/ml
Compatible 100/10 mg/ml + injectionFentanyl citrate 50 µg/ml
Compatible 100/10 mg/ml + injectionFluconazole 2 mg/ml
Compatible 100/10 mg/ml + injectionFurosemide 10 mg/ml
Compatible 100/10 mg/ml + injectionGentamicin sulfate 40 mg/ml
Compatible 100/10 mg/ml + injectionGranisetron hydrochloride 1 mg/ml
Incompatible 100/10 mg/ml + injectionHaloperidol lactate 5 mg/ml
Compatible 100/10 mg/ml + injectionHeparin sodium 1000 UI/ml
Incompatible 100/10 mg/ml + injectionHuman albumin 250 mg/ml
Compatible 100/10 mg/ml + injectionHydrocortisone sodium succinate 50 mg/ml
Compatible 100/10 mg/ml + injectionHydromorphone hydrochloride 10 mg/ml
Incompatible 100/10 mg/ml + injectionImipenem - cilastatin sodium 50 mg/ml
Compatible 100/10 mg/ml + injectionInsulin 100 UI/ml
Incompatible 100/10 mg/ml + injectionKetamine hydrochloride 50 mg/ml
Compatible 100/10 mg/ml + injectionL-carnitine 200 mg/ml
Compatible 100/10 mg/ml + injectionLabetalol hydrochloride 5 mg/ml
Compatible 100/10 mg/ml + injectionLevofloxacine 5 mg/ml
Compatible 100/10 mg/ml + injectionLidocaine hydrochloride 1 mg/ml
Compatible 100/10 mg/ml + injectionLinezolid 2 mg/ml
Compatible 100/10 mg/ml + injectionLorazepam 4 mg/ml
Compatible 100/10 mg/ml + injectionMagnesium sulfate 500 mg/ml
Compatible 100/10 mg/ml + injectionMannitol 250 mg/ml
Compatible 100/10 mg/ml + injectionMeropenem 50 mg/ml
Incompatible 100/10 mg/ml + injectionMethylprednisolone sodium succinate 125 mg/ml
Compatible 100/10 mg/ml + injectionMetoclopramide hydrochloride 5 mg/ml
Compatible 100/10 mg/ml + injectionMetronidazole 5 mg/ml
Compatible 100/10 mg/ml + injectionMicafungin 20 mg/ml
Incompatible 100/10 mg/ml + injectionMidazolam hydrochloride 5 mg/ml
Compatible 100/10 mg/ml + injectionMilrinone lactate 1 mg/ml
Compatible 100/10 mg/ml + injectionMorphine sulfate 50 mg/ml
Compatible 100/10 mg/ml + injectionN-acetylcysteine 200 mg/ml
Compatible 100/10 mg/ml + injectionNaloxone hydrochloride 0,4 mg/ml
Incompatible 100/10 mg/ml + injectionNicardipine hydrochloride 1 mg/ml
Incompatible 100/10 mg/ml + injectionNitroglycerin 5 mg/ml
Compatible 100/10 mg/ml + injectionNorepinephrine bitartrate 1 mg/ml
Compatible 100/10 mg/ml + injectionOctreotide acetate 0.5 mg/ml
Incompatible 100/10 mg/ml + injectionOndansetron hydrochloride 2 mg/ml
Compatible 100/10 mg/ml + injectionOxytocin 10 UI/ml
Compatible 100/10 mg/ml + injectionPantoprazole sodium 4 mg/ml
Compatible 100/10 mg/ml + injectionParacetamol 10 mg/ml
Compatible 100/10 mg/ml + injectionPhenylephrine hydrochloride 0,01 mg/ml
Incompatible 100/10 mg/ml + injectionPhenytoin sodium 50 mg/ml
Compatible 100/10 mg/ml + injectionPiperacillin sodium / tazobactam 100 mg/ml
Compatible 100/10 mg/ml + injectionPotassium chloride 2 mEq/l
Compatible 100/10 mg/ml + injectionPotassium phosphate 3 mmol/ml
Compatible 100/10 mg/ml + injectionRocuronium bromide 10 mg/ml
Compatible 100/10 mg/ml + injectionSalbutamol sulfate 1 mg/ml
Compatible 100/10 mg/ml + injectionSodium bicarbonate 84 mg/ml
Compatible 100/10 mg/ml + injectionSufentanil citrate 0,05 mg/ml
Compatible 100/10 mg/ml + injectionThiamine hydrochloride 100 mg/ml
Compatible 100/10 mg/ml + injectionTobramycin sulfate 40 mg/ml
Compatible 100/10 mg/ml + injectionTranexamic acid 100 mg/ml
Compatible 100/10 mg/ml + injectionVancomycin hydrochloride 50 mg/ml
Incompatible 100/10 mg/ml + injectionVerapamil hydrochloride 10 mg/ml
Compatible 100/10 mg/ml + injectionVoriconazole 10 mg/ml
Compatible 100/10 mg/ml + injectionZidovudine 10 mg/ml
injectionAmphotericin B liposomale Antifungal
Compatible 2 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionAmpicillin sodium Antibiotic
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionAtropine sulfate Antimuscarinic
Compatible 0,4 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionAzithromycine Antibiotic
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionCalcium chloride Electrolyte
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionCalcium gluconate Electrolyte
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionCefazolin sodium Antibiotic
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionCefotaxime sodium Antibiotic
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionCefoxitin sodium Antibiotic
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionCeftazidime Antibiotic
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionCeftriaxone disodium Antibiotic
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionCefuroxime sodium Antibiotic
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionCiclosporin Immunosuppressant
Incompatible 50 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionCiprofloxacin lactate Antibiotic
Compatible 2 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionClindamycin phosphate Antibiotic
Incompatible 150 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionCloxacillin sodium Antibiotic
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionCo-trimoxazole Antibiotic
Compatible 16/80 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 4 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionDexmedetomidine Sympathomimetic
Compatible 100 µg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionDiazepam Anxiolytic
Compatible 5 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionDigoxin Cardiotonic
Compatible 250 µg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionDimenhydrinate Antihistamine (H1)
Compatible 10 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Incompatible 50 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionDobutamine hydrochloride Cardiotonic
Incompatible 12,5 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionDopamine hydrochloride Cardiotonic
Compatible 3,2 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionEnalaprilate Antihypertensive
Compatible 1,25 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 1000 µg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionErtapenem Antibiotic
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionErythromycin lactobionate Antibiotic
Incompatible 50 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionFamotidine Antihistamine (H2)
Compatible 10 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionFentanyl citrate Analgesic
Compatible 50 µg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionFurosemide Diuretic
Compatible 10 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionGentamicin sulfate Antibiotic
Compatible 40 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionGranisetron hydrochloride Antiemetic
Compatible 1 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionHaloperidol lactate Neuroleptic
Incompatible 5 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionHeparin sodium Anticoagulant
Compatible 1000 UI/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionHuman albumin Various
Incompatible 250 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 50 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionHydromorphone hydrochloride Analgesic
Compatible 10 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionImipenem - cilastatin sodium Antibiotic
Incompatible 50 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionInsulin Glucose-lowering
Compatible 100 UI/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionKetamine hydrochloride General anesthetic
Incompatible 50 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionL-carnitine Various
Compatible 200 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionLabetalol hydrochloride Beta-blocker
Compatible 5 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionLevofloxacine Antibiotic
Compatible 5 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionLidocaine hydrochloride Local anesthetic
Compatible 1 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionLinezolid Antibiotic
Compatible 2 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionLorazepam Anxiolytic
Compatible 4 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionMagnesium sulfate Electrolyte
Compatible 500 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionMannitol Various
Compatible 250 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionMeropenem Antibiotic
Compatible 50 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionMethylprednisolone sodium succinate Anti-inflammatory
Incompatible 125 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionMicafungin Antifungal
Compatible 20 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionMidazolam hydrochloride Anxiolytic
Incompatible 5 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionMilrinone lactate Cardiotonic
Compatible 1 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionMorphine sulfate Analgesic
Compatible 50 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionN-acetylcysteine Antidote
Compatible 200 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionNaloxone hydrochloride Antidote
Compatible 0,4 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionNicardipine hydrochloride Vasodilator
Incompatible 1 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionNitroglycerin Vasodilator
Incompatible 5 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 1 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionOctreotide acetate Various
Compatible 0.5 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionOndansetron hydrochloride Antiemetic
Incompatible 2 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionOxytocin Various
Compatible 10 UI/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionPantoprazole sodium Proton pump inhibitor
Compatible 4 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionParacetamol Analgesic
Compatible 10 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionPhenylephrine hydrochloride Sympathomimetic
Compatible 0,01 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionPhenytoin sodium Antiepileptic
Incompatible 50 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionPiperacillin sodium / tazobactam Antibiotic
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionPotassium chloride Electrolyte
Compatible 2 mEq/l + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionPotassium phosphate Electrolyte
Compatible 3 mmol/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionRocuronium bromide Curarimimetic
Compatible 10 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionSalbutamol sulfate Beta-stimulant
Compatible 1 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionSufentanil citrate Analgesic
Compatible 0,05 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionThiamine hydrochloride Vitamin
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionTobramycin sulfate Antibiotic
Compatible 40 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionTranexamic acid Anti-bleeding
Compatible 100 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionVancomycin hydrochloride Antibiotic
Compatible 50 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionVerapamil hydrochloride Anti-arrhythmic
Incompatible 10 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionVoriconazole Antifungal
Compatible 10 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml
injectionZidovudine Antiviral
Compatible 10 mg/ml + injectionAmoxicillin sodium / clavulanic acid 100/10 mg/ml

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