Last update :
19/11/2024
References   References 660  
Type : Journal
Web link : https://doi.org/10.1177/106002809603000303

Research teams : Columbus - The Ohio State University Hospitals, Department of Pharmacy
Authors : Michaels MR, Stauffer GL, Haas DP.
Title : Propofol compatibility with other intravenous drug products - Two new methods of evaluating IV emulsion compatibility.
Reference : Ann Pharmacotherapy ; 30: 228-232. 1996

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
injectionAlfentanil hydrochloride Analgesic
Incompatible 500 µg/ml + injectionPropofol
injectionAtracurium besylate Curarimimetic
Incompatible 10 mg/ml + injectionPropofol
injectionBretylium tosilate Anti-arrhythmic
Incompatible 50 mg/ml + injectionPropofol
injectionCalcium chloride Electrolyte
Incompatible 100 mg/ml + injectionPropofol
injectionCeftizoxime sodium Antibiotic
Incompatible 20 mg/ml + injectionPropofol
injectionCimetidine hydrochloride Antihistamine (H2)
Incompatible 150 mg/ml + injectionPropofol
injectionCisplatin Anticancer drug
Incompatible 0.3 mg/ml + injectionPropofol
injectionCyclophosphamide Anticancer drug
Incompatible 4 mg/ml + injectionPropofol
injectionDexamethasone sodium phosphate Anti-inflammatory
Incompatible 4 mg/ml + injectionPropofol
injectionDiazepam Anxiolytic
Incompatible 5 mg/ml + injectionPropofol
injectionDigoxin Cardiotonic
Incompatible 250 µg/ml + injectionPropofol
injectionDobutamine hydrochloride Cardiotonic
Incompatible 1 mg/ml + injectionPropofol
injectionDopamine hydrochloride Cardiotonic
Incompatible 1.6 mg/ml + injectionPropofol
injectionDoxorubicin hydrochloride Anticancer drug
Incompatible 2 mg/ml + injectionPropofol
injectionEphedrine sulfate Sympathomimetic
Incompatible 5 mg/ml + injectionPropofol
injectionEpinephrine hydrochloride Sympathomimetic
Incompatible 0.1 µg/ml + injectionPropofol
injectionFamotidine Antihistamine (H2)
Incompatible 0.04 mg/ml + injectionPropofol
injectionFluconazole Antifungal
Incompatible 2 mg/ml + injectionPropofol
injectionGentamicin sulfate Antibiotic
Incompatible 2 mg/ml + injectionPropofol
injectionGlycopyrronium bromide Antimuscarinic
Incompatible 0.2 mg/ml + injectionPropofol
injectionHeparin sodium Anticoagulant
Incompatible 1000 UI/ml + injectionPropofol
injectionHydralazine hydrochloride Antihypertensive
Incompatible 20 mg/ml + injectionPropofol
injectionImipenem - cilastatin sodium Antibiotic
Incompatible 5 mg/ml + injectionPropofol
injectionKetamine hydrochloride General anesthetic
Incompatible 10 mg/ml + injectionPropofol
injectionLidocaine hydrochloride Local anesthetic
Incompatible 10 mg/ml + injectionPropofol
injectionMethylprednisolone sodium succinate Anti-inflammatory
Incompatible 63 mg/ml + injectionPropofol
injectionMetoclopramide hydrochloride Antiemetic
Incompatible 5 mg/ml + injectionPropofol
injectionMidazolam hydrochloride Anxiolytic
Incompatible 1 mg/ml + injectionPropofol
injectionMorphine sulfate Analgesic
Incompatible 10 mg/ml + injectionPropofol
injectionNaloxone hydrochloride Antidote
Incompatible 0.4 mg/ml + injectionPropofol
injectionPancuronium bromide Curarimimetic
Incompatible 1 mg/ml + injectionPropofol
injectionPentobarbital sodium General anesthetic
Incompatible 50 mg/ml + injectionPropofol
injectionPhenobarbital sodium Antiepileptic
Incompatible 65 mg/ml + injectionPropofol
injectionPhenylephrine hydrochloride Sympathomimetic
Incompatible 0.1 mg/ml + injectionPropofol
injectionPhenytoin sodium Antiepileptic
Incompatible 50 mg/ml + injectionPropofol
injectionPotassium chloride Electrolyte
Incompatible 200 mEq/l + injectionPropofol
injectionPropofol General anesthetic
Factors which affect stability Solvent Glucose 5% Induces Degradation
Factors which affect stability Solvent NaHCO3 Induces Degradation
Incompatible + NaHCO3
Incompatible + Glucose 5%
Incompatible + injectionAlfentanil hydrochloride 500 µg/ml
Incompatible + injectionAtracurium besylate 10 mg/ml
Incompatible + injectionBretylium tosilate 50 mg/ml
Incompatible + injectionCalcium chloride 100 mg/ml
Incompatible + injectionCeftizoxime sodium 20 mg/ml
Incompatible + injectionCimetidine hydrochloride 150 mg/ml
Incompatible + injectionCisplatin 0.3 mg/ml
Incompatible + injectionCyclophosphamide 4 mg/ml
Incompatible + injectionDexamethasone sodium phosphate 4 mg/ml
Incompatible + injectionDiazepam 5 mg/ml
Incompatible + injectionDigoxin 250 µg/ml
Incompatible + injectionDobutamine hydrochloride 1 mg/ml
Incompatible + injectionDopamine hydrochloride 1.6 mg/ml
Incompatible + injectionDoxorubicin hydrochloride 2 mg/ml
Incompatible + injectionEphedrine sulfate 5 mg/ml
Incompatible + injectionEpinephrine hydrochloride 0.1 µg/ml
Incompatible + injectionFamotidine 0.04 mg/ml
Incompatible + injectionFluconazole 2 mg/ml
Incompatible + injectionGentamicin sulfate 2 mg/ml
Incompatible + injectionGlycopyrronium bromide 0.2 mg/ml
Incompatible + injectionHeparin sodium 1000 UI/ml
Incompatible + injectionHydralazine hydrochloride 20 mg/ml
Incompatible + injectionImipenem - cilastatin sodium 5 mg/ml
Incompatible + injectionKetamine hydrochloride 10 mg/ml
Incompatible + injectionLidocaine hydrochloride 10 mg/ml
Incompatible + injectionMethylprednisolone sodium succinate 63 mg/ml
Incompatible + injectionMetoclopramide hydrochloride 5 mg/ml
Incompatible + injectionMidazolam hydrochloride 1 mg/ml
Incompatible + injectionMorphine sulfate 10 mg/ml
Incompatible + injectionNaloxone hydrochloride 0.4 mg/ml
Incompatible + injectionPancuronium bromide 1 mg/ml
Incompatible + injectionPentobarbital sodium 50 mg/ml
Incompatible + injectionPhenobarbital sodium 65 mg/ml
Incompatible + injectionPhenylephrine hydrochloride 0.1 mg/ml
Incompatible + injectionPhenytoin sodium 50 mg/ml
Incompatible + injectionPotassium chloride 200 mEq/l
Incompatible + injectionPropranolol hydrochloride 1 mg/ml
Incompatible + injectionRanitidine hydrochloride 25 mg/ml
Incompatible + injectionScopolamine hydrobromide 0.4 mg/ml
Incompatible + injectionSodium bicarbonate 84 mg/ml
Incompatible + injectionTicarcillin / clavulanic acid 31 mg/ml
Incompatible + injectionTobramycin sulfate 2 mg/ml
Incompatible + injectionVancomycin hydrochloride 4 mg/ml
Incompatible + injectionVecuronium bromide 1 mg/ml
Incompatible + injectionVerapamil hydrochloride 2.5 mg/ml
injectionPropranolol hydrochloride Beta-blocker
Incompatible 1 mg/ml + injectionPropofol
injectionRanitidine hydrochloride Antihistamine (H2)
Incompatible 25 mg/ml + injectionPropofol
injectionScopolamine hydrobromide Antimuscarinic
Incompatible 0.4 mg/ml + injectionPropofol
injectionSodium bicarbonate Electrolyte
Incompatible 84 mg/ml + injectionPropofol
injectionTicarcillin / clavulanic acid Antibiotic
Incompatible 31 mg/ml + injectionPropofol
injectionTobramycin sulfate Antibiotic
Incompatible 2 mg/ml + injectionPropofol
injectionVancomycin hydrochloride Antibiotic
Incompatible 4 mg/ml + injectionPropofol
injectionVecuronium bromide Curarimimetic
Incompatible 1 mg/ml + injectionPropofol
injectionVerapamil hydrochloride Anti-arrhythmic
Incompatible 2.5 mg/ml + injectionPropofol

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