Last update :
19/11/2024
Antidote   Naloxone hydrochloride  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

DBL Naloxone Malaysia, New Zealand
Grayxona Argentina
Lefebre Mexico
Mapin Malaysia
Miniject Naloxone Great Britain
Naloxan Iran
Naloxon Belgium, Germany, Iceland, Norway, Sweden, Switzerland
Naloxona Argentina, Chile, Colombia, Spain
Naloxone Australia, Canada, Great Britain, Iran, Ireland, Italy, New Zealand, Saudi Arabia, Spain, United States of America
Naloxonum Poland
Narcan Australia, France, Great Britain, Greece, Ireland, Italy, Luxembourg, Netherlands, New Zealand, Switzerland, United States of America
Narcanti Austria, Chile, Denmark, Finland, Germany, Hungary, Sweden
Narcotan India
Narxona Argentina
Naxan Portugal
Naxone Saudi Arabia
Nexodal Norway, Romania, Spain, Sweden
Compatibility   injection   Compatibility : Naloxone hydrochloride              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Unspecified incompatibility Incompatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Aciclovir sodium 50 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Amikacin sulfate 250 mg/ml
None 3408
Unspecified incompatibility Incompatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Aminophylline 50 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Amiodarone hydrochloride 50 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0,4 mg/ml
injection Amoxicillin sodium / clavulanic acid 100/10 mg/ml
3824
Unspecified incompatibility Incompatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Amphotericin B 4 mg/ml
None 3408
Immediate precipitation Incompatible
injection Naloxone hydrochloride 0,4 mg/ml
injection Amphotericin B cholesteryl sulfate complex 0,83 mg/ml
Glucose 5% 921
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Ampicillin sodium 250 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Atropine sulfate 0.4 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Azithromycine 500 mg/ml
None 3408
Immediate precipitation Incompatible
injection Naloxone hydrochloride 0.2 mg/ml
injection Blinatumomab 0.125 & 0.375 µg/ml
Sodium chloride 0,9% 3976
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Caffeine 10 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Caffeine 10 mg/ml
None 3964
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Calcium chloride 78 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Calcium gluconate 100 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Caspofungin acetate 5 mg/ml
None 3408
Unspecified incompatibility Incompatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Cefazolin sodium 100 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.04 mg/ml
injection Cefiderocol sulfate tosylate 20 mg/mL
NaCl 0,9% or Glucose 5% 4528
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Cefotaxime sodium 100 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Cefoxitin sodium 100 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Ceftazidime 100 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.04 mg/ml
injection Ceftolozane / tazobactam 10/5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Ceftriaxone disodium 100 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Cefuroxime sodium 100 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Chlorpromazine hydrochloride 25 mg/ml
None 3408
Immediate precipitation Incompatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Ciclosporin 50 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Ciprofloxacin lactate 2 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Clindamycin phosphate 150 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Cloxacillin sodium 250 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Cloxacillin sodium 100 mg/ml
Water for Injection 3012
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Co-trimoxazole
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Defibrotide 8 mg/ml
Sodium chloride 0,9% 3728
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Dexamethasone sodium phosphate 4 mg/ml
None 3408
Immediate precipitation Incompatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Diazepam 5 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Digoxin 50 µg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Dimenhydrinate 10 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride
injection Dimenhydrinate
2087
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Diphenhydramine hydrochloride 50 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Dobutamine hydrochloride 12.5 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Dopamine hydrochloride 40 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Droperidol 2.5 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Epinephrine hydrochloride 1000 µg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Erythromycin lactobionate 50 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Esmolol hydrochloride 10 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Fenoldopam mesylate 80 µg/ml
Sodium chloride 0,9% 1803
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Fentanyl citrate 50 µg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Fluconazole 2 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.04 mg/ml
injection Fosfomycin 30 mg/ml
NaCl 0,9% or Glucose 5% 4055
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Furosemide 10 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Gentamicin sulfate 40 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Heparin sodium 1000 UI/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Hydralazine hydrochloride 1 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Hydrocortisone sodium succinate 125 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Hydromorphone hydrochloride 10 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0,004 mg/ml
injection Imipenem-Cilastatin / Relebactam 5 mg/ml
NaCl 0,9% or Glucose 5% 4433
Precipitation after 15 minutes Incompatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Indomethacin sodium trihydrate 0.5 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Insulin 100 UI/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.04 mg/ml
injection Isavuconazonium sulfate 1.5 mg/ml
NaCl 0,9% or Glucose 5% 3829
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Isoprenaline hydrochloride 0.2 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Ketamine hydrochloride 50 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Ketamine hydrochloride 50 mg/ml
2109
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection L-carnitine 200 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Labetalol hydrochloride 5 mg/ml
None 3408
Precipitation after 1 hour Incompatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Lansoprazole 0.55 mg/ml
Sodium chloride 0,9% 1625
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Levofloxacine 0.5 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Lidocaine hydrochloride 1 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Linezolid 2 mg/ml
None 1925
Precipitation after 15 minutes Incompatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Lorazepam 4 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Magnesium sulfate 500 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Mannitol 250 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Meropenem 50 mg/ml
Water for Injection 4319
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Meropenem 50 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Methylprednisolone acetate 62.5 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Metoclopramide hydrochloride 5 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Metronidazole 5 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Midazolam hydrochloride 5 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Milrinone lactate 1 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0,004 >> 0,025 mg/ml
injection Morphine sulfate 1 mg/ml
Sodium chloride 0,9% 3434
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection N-acetylcysteine 200 mg/ml
None 3408
Immediate precipitation Incompatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Nitroglycerin 5 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Nitroprusside sodium 10 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Norepinephrine bitartrate 1 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Octreotide acetate 0.5 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Ondansetron hydrochloride 2 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.133 mg/ml
injection Ondansetron hydrochloride 1.33 mg/ml
Sodium chloride 0,9% 815
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Oxytocin 10 UI/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Pancuronium bromide 2 mg/ml
None 3408
Precipitation after 4 hours Incompatible
injection Naloxone hydrochloride
injection Pantoprazole sodium
2090
Immediate precipitation Incompatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Pantoprazole sodium 4 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Paracetamol 10 mg/ml
4742
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Phenobarbital sodium 60 mg/ml
None 3408
Precipitation after 15 minutes Incompatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Phenytoin sodium 50 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Piperacillin sodium 200 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Piperacillin sodium / tazobactam 200 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.04 mg/ml
injection Plazomicin sulfate 24 mg/ml
Sodium chloride 0,9% 4145
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Potassium chloride 200 mEq/l
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Potassium phosphate 3 mmol/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Promethazine hydrochloride 25 mg/ml
None 3408
Instability of the emulsion after 4 hours Incompatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Propofol
660
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Propofol 10 mg/ml
None 300
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Propranolol hydrochloride 1 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Ranitidine hydrochloride 25 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Rocuronium bromide 10 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Salbutamol sulfate 1 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Sodium bicarbonate 84 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Sufentanil citrate 0.05 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Sugammadex 100 mg/ml
None 3372
Compatible
injection Naloxone hydrochloride 0,04 mg/ml
injection Sulbactam/durlobactam 15/15 mg/ml
Sodium chloride 0,9% 4801
Compatible
injection Naloxone hydrochloride 0.04 mg/ml
injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3827
Turbidity in 15 minutes Incompatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Thiopental sodium 125 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Ticarcillin / clavulanic acid 200 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Tobramycin sulfate 40 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Valproic acid 100 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0,4 mg/ml
Ringer’s lactate solution 4603
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Vancomycin hydrochloride 50 mg/ml
None 3408
Compatible
injection Naloxone hydrochloride 0.0008 mg/ml
injection Verapamil hydrochloride 0.08 mg/ml
NaCl 0,9% or Glucose 5% 1057
Compatible
injection Naloxone hydrochloride 0.4 mg/ml
injection Voriconazole 10 mg/ml
None 3408

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