Bibliographie - 4837 - Stabilis 4.0

Last update :
14/02/2025

References 4837

Type :

Journal

Web link :

https://doi.org/10.1007/s00228-024-03678-6

Research teams :

Bentley - Curtin Medical School, Curtin University, Bentley, WA, Australia

Authors :

De Silva, D.T.N Petrovski M, Strunk T, Mukadam N, Page‑Sharp N, Moore B.R, Batty K.T.

Title :

Physicochemical compatibility of caffeine citrate and caffeine base injections with parenteral medications used in neonatal intensive care settings.

Reference :

Eur J Clin Pharmacol ; 80:1079–1087. 2024

Level of Evidence :

Physical stability :

Chemical stability :

Other methods :

Comments :

List of drugs

Aciclovir sodium

	5 mg/ml	+ Caffeine	10 mg/ml	+
	5 mg/ml	+ Caffeine citrate	20 mg/ml

Alprostadil

	20 µg/ml	+ Caffeine	10 mg/ml	+
	20 µg/ml	+ Caffeine citrate	20 mg/ml	+

Amoxicillin sodium

	100 mg/ml	+ Caffeine	10 mg/ml	+
	100 mg/ml	+ Caffeine citrate	20 mg/ml	+

Amphotericin B

	0.1 mg/ml	+ Caffeine	10 mg/ml	+
	0,1 mg/ml	+ Caffeine citrate	20 mg/ml	+

Amphotericin B liposomale

	2 mg/ml	+ Caffeine	10 mg/ml	+
	2 mg/ml	+ Caffeine citrate	20 mg/ml

Ampicillin sodium

	100 mg/ml	+ Caffeine	10 mg/ml	+
	100 mg/ml	+ Caffeine citrate	20 mg/ml	+

Caffeine

10 mg/ml	+ Aciclovir sodium	5 mg/ml	+
10 mg/ml	+ Alprostadil	20 µg/ml	+
10 mg/ml	+ Amoxicillin sodium	100 mg/ml	+
10 mg/ml	+ Amphotericin B	0.1 mg/ml	+
10 mg/ml	+ Amphotericin B liposomale	2 mg/ml	+
10 mg/ml	+ Ampicillin sodium	100 mg/ml	+
10 mg/ml	+ Calcium gluconate	100 mg/ml
10 mg/ml	+ Cefotaxime sodium	100 mg/ml
10 mg/ml	+ Ciprofloxacin lactate	2 mg/ml
2 mg/ml	+ Clonidine hydrochloride	0.02 mg/ml	+
10 mg/ml	+ Cloxacillin sodium	100 mg/ml	+
10 mg/ml	+ Dexmedetomidine	1 µg/ml	+
10 mg/ml	+ Dobutamine hydrochloride	7.2 mg/ml	+
10 mg/ml	+ Dopamine hydrochloride	7.2 mg/ml	+
10 mg/ml	+ Epinephrine hydrochloride	64 µg/ml	+
10 mg/ml	+ Fentanyl citrate	50 µg/ml
10 mg/ml	+ Flucloxacillin sodium	50 mg/ml	+
10 mg/ml	+ Fluconazole	2 mg/ml
10 mg/ml	+ Furosemide	1 mg/ml	+
10 mg/ml	+ Gentamicin sulfate	10 mg/ml	+
10 mg/ml	+ Heparin sodium	100 UI/ml	+
10 mg/ml	+ Hydrocortisone sodium succinate	10 mg/ml	+
10 mg/ml	+ Ibuprofen lysinate	4 mg/ml	+
10 mg/ml	+ Indomethacin sodium trihydrate	0.2 mg/ml	+
10 mg/ml	+ Insulin	0.2 UI/ml	+
10 mg/ml	+ Levetiracetam	5 mg/ml	+
10 mg/ml	+ Linezolid	2 mg/ml	+
10 mg/ml	+ Linezolid	2 mg/ml
10 mg/ml	+ Meropenem	50 mg/ml	+
10 mg/ml	+ Metronidazole	5 mg/ml
10 mg/ml	+ Midazolam hydrochloride	1 mg/ml
10 mg/ml	+ Milrinone lactate	0.4 mg/ml	+
10 mg/ml	+ Morphine hydrochloride	0.2 mg/ml	+
10 mg/ml	+ Morphine sulfate	0.2 mg/ml	+
10 mg/ml	+ Norepinephrine bitartrate	64 mg/ml	+
10 mg/ml	+ Norepinephrine bitartrate	0.064 mg/ml	+
10 mg/ml	+ Paracetamol	10 mg/ml
10 mg/ml	+ Penicillin G sodium	0.17 MUI/ml	+
10 mg/ml	+ Phenobarbital sodium	20 mg/ml	+
10 mg/ml	+ Piperacillin sodium / tazobactam	200 mg/ml	+
10 mg/ml	+ Rifampicin	6 mg/ml	+
10 mg/ml	+ Sodium bicarbonate	42 mg/ml	+
10 mg/ml	+ Vancomycin hydrochloride	10 mg/ml	+
10 mg/ml	+ Vecuronium bromide	1 mg/ml	+

Caffeine citrate

20 mg/ml	+ Aciclovir sodium	5 mg/ml
20 mg/ml	+ Alprostadil	20 µg/ml	+
20 mg/ml	+ Amoxicillin sodium	100 mg/ml	+
20 mg/ml	+ Amphotericin B	0,1 mg/ml	+
20 mg/ml	+ Amphotericin B liposomale	2 mg/ml
20 mg/ml	+ Ampicillin sodium	100 mg/ml	+
20 mg/ml	+ Calcium gluconate	100 mg/ml
20 mg/ml	+ Cefotaxime sodium	100 mg/ml	+
20 mg/ml	+ Ciprofloxacin lactate	2 mg/ml
20 mg/ml	+ Clonidine hydrochloride	0,002 mg/ml	+
20 mg/ml	+ Cloxacillin sodium	100 mg/ml	+
20 mg/ml	+ Dexmedetomidine	1 µg/ml	+
20 mg/ml	+ Dobutamine hydrochloride	7,2 mg/ml	+
20 mg/ml	+ Dopamine hydrochloride	7,2 mg/ml	+
20 mg/ml	+ Epinephrine hydrochloride	64 µg/ml	+
20 mg/ml	+ Fentanyl citrate	50 µg/ml
20 mg/ml	+ Flucloxacillin sodium	50 mg/ml	+
20 mg/ml	+ Fluconazole	2 mg/ml
20 mg/ml	+ Gentamicin sulfate	10 mg/ml	+
20 mg/ml	+ Heparin sodium	100 UI/ml	+
20 mg/ml	+ Hydrocortisone sodium succinate	1 mg/ml	+
20 mg/ml	+ Hydrocortisone sodium succinate	10 mg/ml	+
20 mg/ml	+ Ibuprofen lysinate	4 mg/ml	+
20 mg/ml	+ Indomethacin sodium trihydrate	0,2 mg/ml	+
20 mg/ml	+ Insulin	0,2 UI/ml	+
20 mg/ml	+ Levetiracetam	5 mg/ml	+
20 mg/ml	+ Linezolid	2 mg/ml
20 mg/ml	+ Meropenem	50 mg/ml	+
20 mg/ml	+ Metronidazole	5 mg/ml
20 mg/ml	+ Midazolam hydrochloride	1 mg/ml
20 mg/ml	+ Milrinone lactate	0,4 mg/ml	+
20 mg/ml	+ Morphine hydrochloride	0,2 mg/ml	+
20 mg/ml	+ Morphine sulfate	0,2 mg/ml	+
20 mg/ml	+ Norepinephrine bitartrate	0,064 mg/ml	+
20 mg/ml	+ Paracetamol	10 mg/ml
20 mg/ml	+ Penicillin G sodium	0.17 MUI/ml	+
20 mg/ml	+ Phenobarbital sodium	20 mg/ml	+
20 mg/ml	+ Piperacillin sodium / tazobactam	200 mg/ml	+
20 mg/ml	+ Rifampicin	6 mg/ml	+
20 mg/ml	+ Sodium bicarbonate	42 mg/ml	+
20 mg/ml	+ Vancomycin hydrochloride	10 mg/ml	+
20 mg/ml	+ Vecuronium bromide	1 mg/ml	+

Calcium gluconate

	100 mg/ml	+ Caffeine	10 mg/ml
	100 mg/ml	+ Caffeine citrate	20 mg/ml

Cefotaxime sodium

	100 mg/ml	+ Caffeine	10 mg/ml
	100 mg/ml	+ Caffeine citrate	20 mg/ml	+

Ciprofloxacin lactate

	2 mg/ml	+ Caffeine	10 mg/ml
	2 mg/ml	+ Caffeine citrate	20 mg/ml

Clonidine hydrochloride

	0.02 mg/ml	+ Caffeine	2 mg/ml	+
	0,002 mg/ml	+ Caffeine citrate	20 mg/ml	+

Cloxacillin sodium

	100 mg/ml	+ Caffeine	10 mg/ml	+
	100 mg/ml	+ Caffeine citrate	20 mg/ml	+

Dexmedetomidine

	1 µg/ml	+ Caffeine	10 mg/ml	+
	1 µg/ml	+ Caffeine citrate	20 mg/ml	+

Dobutamine hydrochloride

	7.2 mg/ml	+ Caffeine	10 mg/ml	+
	7,2 mg/ml	+ Caffeine citrate	20 mg/ml	+

Dopamine hydrochloride

	7.2 mg/ml	+ Caffeine	10 mg/ml	+
	7,2 mg/ml	+ Caffeine citrate	20 mg/ml	+

Epinephrine hydrochloride

	64 µg/ml	+ Caffeine	10 mg/ml	+
	64 µg/ml	+ Caffeine citrate	20 mg/ml	+

Fentanyl citrate

	50 µg/ml	+ Caffeine	10 mg/ml
	50 µg/ml	+ Caffeine citrate	20 mg/ml

Flucloxacillin sodium

	50 mg/ml	+ Caffeine	10 mg/ml	+
	50 mg/ml	+ Caffeine citrate	20 mg/ml	+

Fluconazole

	2 mg/ml	+ Caffeine	10 mg/ml
	2 mg/ml	+ Caffeine citrate	20 mg/ml

Furosemide

1 mg/ml

Caffeine

10 mg/ml

Gentamicin sulfate

	10 mg/ml	+ Caffeine	10 mg/ml	+
	10 mg/ml	+ Caffeine citrate	20 mg/ml	+

Heparin sodium

	100 UI/ml	+ Caffeine	10 mg/ml	+
	100 UI/ml	+ Caffeine citrate	20 mg/ml	+

Hydrocortisone sodium succinate

10 mg/ml	+ Caffeine	10 mg/ml	+
10 mg/ml	+ Caffeine citrate	20 mg/ml	+
1 mg/ml	+ Caffeine citrate	20 mg/ml	+

Ibuprofen lysinate

	4 mg/ml	+ Caffeine	10 mg/ml	+
	4 mg/ml	+ Caffeine citrate	20 mg/ml	+

Indomethacin sodium trihydrate

	0.2 mg/ml	+ Caffeine	10 mg/ml	+
	0,2 mg/ml	+ Caffeine citrate	20 mg/ml	+

Insulin

	0.2 UI/ml	+ Caffeine	10 mg/ml	+
	0,2 UI/ml	+ Caffeine citrate	20 mg/ml	+

Levetiracetam

	5 mg/ml	+ Caffeine	10 mg/ml	+
	5 mg/ml	+ Caffeine citrate	20 mg/ml	+

Linezolid

2 mg/ml	+ Caffeine	10 mg/ml
2 mg/ml	+ Caffeine	10 mg/ml	+
2 mg/ml	+ Caffeine citrate	20 mg/ml

Meropenem

	50 mg/ml	+ Caffeine	10 mg/ml	+
	50 mg/ml	+ Caffeine citrate	20 mg/ml	+

Metronidazole

	5 mg/ml	+ Caffeine	10 mg/ml
	5 mg/ml	+ Caffeine citrate	20 mg/ml

Midazolam hydrochloride

	1 mg/ml	+ Caffeine	10 mg/ml
	1 mg/ml	+ Caffeine citrate	20 mg/ml

Milrinone lactate

	0.4 mg/ml	+ Caffeine	10 mg/ml	+
	0,4 mg/ml	+ Caffeine citrate	20 mg/ml	+

Morphine hydrochloride

	0.2 mg/ml	+ Caffeine	10 mg/ml	+
	0,2 mg/ml	+ Caffeine citrate	20 mg/ml	+

Morphine sulfate

	0.2 mg/ml	+ Caffeine	10 mg/ml	+
	0,2 mg/ml	+ Caffeine citrate	20 mg/ml	+

Norepinephrine bitartrate

64 mg/ml	+ Caffeine	10 mg/ml	+
0.064 mg/ml	+ Caffeine	10 mg/ml	+
0,064 mg/ml	+ Caffeine citrate	20 mg/ml	+

Paracetamol

	10 mg/ml	+ Caffeine	10 mg/ml
	10 mg/ml	+ Caffeine citrate	20 mg/ml

Penicillin G sodium

	0.17 MUI/ml	+ Caffeine	10 mg/ml	+
	0.17 MUI/ml	+ Caffeine citrate	20 mg/ml	+

Phenobarbital sodium

	20 mg/ml	+ Caffeine	10 mg/ml	+
	20 mg/ml	+ Caffeine citrate	20 mg/ml	+

Piperacillin sodium / tazobactam

	200 mg/ml	+ Caffeine	10 mg/ml	+
	200 mg/ml	+ Caffeine citrate	20 mg/ml	+

Rifampicin

	6 mg/ml	+ Caffeine	10 mg/ml	+
	6 mg/ml	+ Caffeine citrate	20 mg/ml	+

Sodium bicarbonate

	42 mg/ml	+ Caffeine	10 mg/ml	+
	42 mg/ml	+ Caffeine citrate	20 mg/ml	+

Vancomycin hydrochloride

	10 mg/ml	+ Caffeine	10 mg/ml	+
	10 mg/ml	+ Caffeine citrate	20 mg/ml	+

Vecuronium bromide

	1 mg/ml	+ Caffeine	10 mg/ml	+
	1 mg/ml	+ Caffeine citrate	20 mg/ml	+

Mentions Légales