Last update :
19/11/2024
References   References 4319  
Type : Journal
Web link : https://doi.org/10.1177/0018578719844168

Research teams : Montreal - Centre hospitalier Sainte Justine
Authors : Lessard J-J, Caron E, Schérer H, Forest J-M, Leclair G.
Title : Compatibility of Y-site Injection of Meropenem Trihydrate With 101 Other Injectable Drugs.
Reference : Hosp Pharm ; 55, 5: 332-337. 2020

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAmikacin sulfate Antibiotic
Compatible 250 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionAmiodarone hydrochloride Anti-arrhythmic
Incompatible 50 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionAmphotericin B liposomale Antifungal
Compatible 2 mg/ml + injectionMeropenem 50 mg/ml
injectionAmpicillin sodium Antibiotic
Compatible 250 mg/ml + injectionMeropenem 50 mg/ml
injectionAtropine sulfate Antimuscarinic
Compatible 0.4 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionAzithromycine Antibiotic
Compatible 100 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionAztreonam Antibiotic
Compatible 100 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionBenztropine mesylate Antimuscarinic
Compatible 1 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionBretylium tosilate Anti-arrhythmic
Compatible 50 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionBupivacaine hydrochloride Local anesthetic
Incompatible 5 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionCaffeine citrate Respiratory stimulant
Compatible 20 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionCalcium chloride Electrolyte
Compatible 100 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionCalcium gluconate Electrolyte
Incompatible 100 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionCaspofungin acetate Antifungal
Compatible 0.5 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionCefazolin sodium Antibiotic
Compatible 100 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionCefotaxime sodium Antibiotic
Compatible 100 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionCefoxitin sodium Antibiotic
Compatible 100 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionCeftazidime Antibiotic
Compatible 100 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionCeftriaxone disodium Antibiotic
Compatible 100 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionCefuroxime sodium Antibiotic
Compatible 100 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionCiclosporin Immunosuppressant
Compatible 5 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionCiprofloxacin lactate Antibiotic
Incompatible 2 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionClindamycin phosphate Antibiotic
Compatible 150 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionCloxacillin sodium Antibiotic
Compatible 250 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionCo-trimoxazole Antibiotic
Compatible 80/16 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionColistin mesilate sodium Antibiotic
Compatible 75 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 4 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionDexmedetomidine Sympathomimetic
Compatible 100 µg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionDiazepam Anxiolytic
Incompatible 5 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionDigoxin Cardiotonic
Compatible 250 µg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionDimenhydrinate Antihistamine (H1)
Compatible 10 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionDipyridamol Vasodilator
Incompatible 5 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionDobutamine hydrochloride Cardiotonic
Incompatible 12.5 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionDopamine hydrochloride Cardiotonic
Compatible 32 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 1000 µg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionErtapenem Antibiotic
Compatible 100 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionErythromycin lactobionate Antibiotic
Compatible 50 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionFentanyl citrate Analgesic
Compatible 50 µg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionFoscarnet sodium Antiviral
Compatible 24 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionFurosemide Diuretic
Compatible 10 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionGentamicin sulfate Antibiotic
Compatible 40 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionGranisetron hydrochloride Antiemetic
Compatible 1 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionHeparin sodium Anticoagulant
Compatible 1000 UI/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionHydralazine hydrochloride Antihypertensive
Incompatible 20 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 125 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionHydromorphone hydrochloride Analgesic
Compatible 10 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionHydroxyzine dihydrochloride Anxiolytic
Incompatible 50 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionImipenem - cilastatin sodium Antibiotic
Compatible 50 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionInsulin Glucose-lowering
Compatible 100 UI/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0.2 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionKetamine hydrochloride General anesthetic
Incompatible 50 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionL-carnitine Various
Compatible 200 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionLabetalol hydrochloride Beta-blocker
Compatible 5 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionLidocaine hydrochloride Local anesthetic
Compatible 10 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionLinezolid Antibiotic
Compatible 2 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionMagnesium sulfate Electrolyte
Compatible 500 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionMannitol Various
Compatible 250 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionMeropenem Antibiotic
Compatible 50 mg/ml + injectionAmikacin sulfate 250 mg/ml + Water for Injection
Incompatible 50 mg/ml + injectionAmiodarone hydrochloride 50 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionAmphotericin B liposomale 2 mg/ml
Compatible 50 mg/ml + injectionAmpicillin sodium 250 mg/ml
Compatible 50 mg/ml + injectionAtropine sulfate 0.4 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionAzithromycine 100 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionAztreonam 100 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionBenztropine mesylate 1 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionBretylium tosilate 50 mg/ml + Water for Injection
Incompatible 50 mg/ml + injectionBupivacaine hydrochloride 5 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionCaffeine citrate 20 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionCalcium chloride 100 mg/ml + Water for Injection
Incompatible 50 mg/ml + injectionCalcium gluconate 100 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionCaspofungin acetate 0.5 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionCefazolin sodium 100 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionCefotaxime sodium 100 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionCefoxitin sodium 100 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionCeftazidime 100 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionCeftriaxone disodium 100 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionCefuroxime sodium 100 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionCiclosporin 5 mg/ml + Water for Injection
Incompatible 50 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionClindamycin phosphate 150 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionCloxacillin sodium 250 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionCo-trimoxazole 80/16 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionColistin mesilate sodium 75 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionDexamethasone sodium phosphate 4 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionDexmedetomidine 100 µg/ml + Water for Injection
Incompatible 50 mg/ml + injectionDiazepam 5 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionDigoxin 250 µg/ml + Water for Injection
Compatible 50 mg/ml + injectionDimenhydrinate 10 mg/ml + Water for Injection
Incompatible 50 mg/ml + injectionDipyridamol 5 mg/ml + Water for Injection
Incompatible 50 mg/ml + injectionDobutamine hydrochloride 12.5 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionDopamine hydrochloride 32 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionEpinephrine hydrochloride 1000 µg/ml + Water for Injection
Compatible 50 mg/ml + injectionErtapenem 100 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionErythromycin lactobionate 50 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionEsmolol hydrochloride 10 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionFentanyl citrate 50 µg/ml + Water for Injection
Compatible 50 mg/ml + injectionFluconazole 2 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionFoscarnet sodium 24 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionFurosemide 10 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionGentamicin sulfate 40 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionGranisetron hydrochloride 1 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionHeparin sodium 1000 UI/ml + Water for Injection
Incompatible 50 mg/ml + injectionHydralazine hydrochloride 20 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionHydrocortisone sodium succinate 125 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionHydromorphone hydrochloride 10 mg/ml + Water for Injection
Incompatible 50 mg/ml + injectionHydroxyzine dihydrochloride 50 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionImipenem - cilastatin sodium 50 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionInsulin 100 UI/ml + Water for Injection
Compatible 50 mg/ml + injectionIsoprenaline hydrochloride 0.2 mg/ml + Water for Injection
Incompatible 50 mg/ml + injectionKetamine hydrochloride 50 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionL-carnitine 200 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionLabetalol hydrochloride 5 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionLidocaine hydrochloride 10 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionLinezolid 2 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionMagnesium sulfate 500 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionMannitol 250 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionMethylprednisolone sodium succinate 62.5 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionMetoclopramide hydrochloride 5 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionMetoprolol tartrate 1 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionMetronidazole 5 mg/ml + Water for Injection
Incompatible 50 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionMilrinone lactate 1 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionMorphine sulfate 50 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionN-acetylcysteine 200 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionNaloxone hydrochloride 0.4 mg/ml + Water for Injection
Incompatible 50 mg/ml + injectionNitroglycerin 5 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionNitroprusside sodium 25 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionNorepinephrine bitartrate 1 mg/ml + Water for Injection
Incompatible 50 mg/ml + injectionOndansetron hydrochloride 2 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionOxytocin 10 UI/ml + Water for Injection
Compatible 50 mg/ml + injectionPantoprazole sodium 4 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionPenicillin G sodium 0.5 MUI/ml + Water for Injection
Incompatible 50 mg/ml + injectionPhenytoin sodium 50 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionPiperacillin sodium 200 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionPiperacillin sodium / tazobactam 200 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionPotassium chloride 2000 mEq/l + Water for Injection
Compatible 50 mg/ml + injectionPotassium phosphate 3 mmol/ml + Water for Injection
Compatible 50 mg/ml + injectionProcainamide hydrochloride 100 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionPropranolol hydrochloride 1 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionRanitidine hydrochloride 25 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionRocuronium bromide 10 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionSalbutamol sulfate 1 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionSodium bicarbonate 84 mg/ml + Water for Injection
Incompatible 50 mg/ml + injectionSodium Phosphate 3 mmol/ml + Water for Injection
Compatible 50 mg/ml + injectionSufentanil citrate 0.05 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionTobramycin sulfate 40 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionValproic acid 100 mg/ml + Water for Injection
Incompatible 50 mg/ml + injectionVancomycin hydrochloride 50 mg/ml + Water for Injection
Compatible 50 mg/ml + injectionVoriconazole 10 mg/ml + Water for Injection
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 62.5 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionMetoprolol tartrate Anti-arrhythmic
Compatible 1 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionMidazolam hydrochloride Anxiolytic
Incompatible 1 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionMilrinone lactate Cardiotonic
Compatible 1 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionMorphine sulfate Analgesic
Compatible 50 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionN-acetylcysteine Antidote
Compatible 200 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionNaloxone hydrochloride Antidote
Compatible 0.4 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionNitroglycerin Vasodilator
Incompatible 5 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionNitroprusside sodium Vasodilator
Compatible 25 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 1 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionOndansetron hydrochloride Antiemetic
Incompatible 2 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionOxytocin Various
Compatible 10 UI/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionPantoprazole sodium Proton pump inhibitor
Compatible 4 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionPenicillin G sodium Antibiotic
Compatible 0.5 MUI/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionPhenytoin sodium Antiepileptic
Incompatible 50 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionPiperacillin sodium Antibiotic
Compatible 200 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionPiperacillin sodium / tazobactam Antibiotic
Compatible 200 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionPotassium chloride Electrolyte
Compatible 2000 mEq/l + injectionMeropenem 50 mg/ml + Water for Injection
injectionPotassium phosphate Electrolyte
Compatible 3 mmol/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionProcainamide hydrochloride Anti-arrhythmic
Compatible 100 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionPropranolol hydrochloride Beta-blocker
Compatible 1 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 25 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionRocuronium bromide Curarimimetic
Compatible 10 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionSalbutamol sulfate Beta-stimulant
Compatible 1 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionSodium Phosphate Electrolyte
Incompatible 3 mmol/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionSufentanil citrate Analgesic
Compatible 0.05 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionTobramycin sulfate Antibiotic
Compatible 40 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionValproic acid Antiepileptic
Compatible 100 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionVancomycin hydrochloride Antibiotic
Incompatible 50 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection
injectionVoriconazole Antifungal
Compatible 10 mg/ml + injectionMeropenem 50 mg/ml + Water for Injection

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