Last update :
19/11/2024
General anesthetic   Ketamine hydrochloride  
injection
Oral solution
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Aescoket Italy
Anesket Colombia, Mexico
Calypsol Hungary, Malaysia, Poland, Romania, Thailand
Inducmina Argentina, Peru
Kanox Malaysia
Keiram Egypt, Venezuela
Keta Germany, India
Keta Hameln Peru
Ketafast India
Ketajet India
Ketalar Australia, Belgium, Brazil, Canada, Chile, Colombia, Denmark, Finland, Great Britain, Ireland, Luxembourg, Netherlands, New Zealand, Norway, Portugal, Sweden, Turkey, United Arab Emirates, United States of America
Ketalin Mexico
Ketamar Egypt
Ketamax India, Venezuela
Ketamin Germany
Ketamina Argentina, Chile, Colombia, Peru, Venezuela
Ketamine Canada, Egypt, France, Ireland, Italy, Malaysia, New Zealand, Romania, Tunisia, United States of America
Ketanest Poland
Ketanir Colombia, Ecuador, Peru
Ketashort Colombia
Ketava Malaysia
Ketmin India
Ketolar Spain
Ketsia India
Kmin India
Tekam Saudi Arabia, United Arab Emirates
Compatibility   injection   Compatibility : Ketamine hydrochloride              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
NaHCO3 2109
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Aciclovir sodium 50 mg/ml
2109
Compatible
injection Ketamine hydrochloride 5 mg/ml
injection Alprostadil 20 µg/ml
Glucose 5% 4491
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Alprostadil 500 µg/ml
4389
Compatible
injection Ketamine hydrochloride 5 mg/ml
injection Alprostadil 20 µg/ml
Glucose 5% 4651
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Amikacin sulfate 250 mg/ml
2109
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Aminophylline 25 mg/ml
4389
Immediate turbidity Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Aminophylline 50 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Amiodarone hydrochloride 50 mg/ml
2109
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Amoxicillin sodium / clavulanic acid 100/10 mg/ml
3824
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Ampicillin sodium 250 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Atropine sulfate 0.4 mg/ml
2109
Compatible
injection Ketamine hydrochloride 1 >> 4 mg/ml
injection Butorphanol tartrate 0.05 >> 0.15 mg/ml
Sodium chloride 0,9% 181
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Caffeine 10 mg/ml
None 3964
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Caffeine 10 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Calcium gluconate 100 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Cefazolin sodium 100 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Cefotaxime sodium 100 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Ceftazidime 100 mg/ml
2109
Compatible
injection Ketamine hydrochloride 10 mg/ml
injection Ceftazidime 83.3 mg/ml
1759
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Cefuroxime sodium 100 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Chlorpromazine hydrochloride 25 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Clindamycin phosphate 150 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Cloxacillin sodium 100 mg/ml
2109
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Co-trimoxazole 80/16 mg/ml
2109
Immediate precipitation Incompatible
injection Ketamine hydrochloride
injection Diazepam
3501
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Digoxin 50 µg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Dimenhydrinate 50 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Diphenhydramine hydrochloride 50 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Dobutamine hydrochloride 12.5 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Dopamine hydrochloride 40 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Epinephrine hydrochloride 1000 µg/ml
2109
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Insulin 100 UI/ml
2109
Compatible
injection Ketamine hydrochloride 10 mg/ml
Parenteral nutrition (with lipids) 4507
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Isoprenaline hydrochloride 0,2 mg/ml
4389
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
Ringer’s lactate solution 4603
Compatible
injection Ketamine hydrochloride 10 mg/ml
injection Cefepime dihydrochloride 125 mg/ml
Water for Injection 2141
Compatible
injection Ketamine hydrochloride 10 mg/ml
injection Ceftazidime 125 mg/ml
Water for Injection 2141
Immediate turbidity Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Ciclosporin 50 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Ciclosporin 50 mg/ml
4389
Compatible
injection Ketamine hydrochloride 25 mg/ml
injection Clonidine hydrochloride 0.015 mg/ml
Sodium chloride 0,9% 3705
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Cloxacillin sodium 100 mg/ml
Water for Injection 3012
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Dexamethasone sodium phosphate 4 mg/ml
4389
Immediate turbidity Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Dexamethasone sodium phosphate 10 mg/ml
2109
Compatible
injection Ketamine hydrochloride 3.57 & 42.85 mg/ml
injection Dexamethasone sodium phosphate 0.07 mg/ml
Sodium chloride 0,9% 2022
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Dexmedetomidine 100 µg/ml
4389
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Esmolol hydrochloride 10 mg/ml
4389
Compatible
injection Ketamine hydrochloride 0,19 mg/ml
injection Fentanyl citrate 9,8 µg/ml
Glucose 5% 4436
Compatible
injection Ketamine hydrochloride 1 mg/ml
injection Fentanyl citrate 40 µg/ml
Sodium chloride 0,9% 1934
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Furosemide 10 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Gentamicin sulfate 40 mg/ml
2109
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Heparin sodium 25000 UI/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Hydrocortisone sodium succinate 125 mg/ml
2109
Compatible
injection Ketamine hydrochloride 0.2 >> 1 mg/ml
injection Hydromorphone hydrochloride 0.2 mg/ml
Sodium chloride 0,9% 2336
Chemical instability Incompatible
injection Ketamine hydrochloride
injection Hydroxocobalamin
3932
Compatible
injection Ketamine hydrochloride 2.5 mg/ml
injection Lidocaine hydrochloride 20 mg/ml
Sodium chloride 0,9% 4350
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Lorazepam 4 mg/ml
4389
Immediate turbidity Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Lorazepam 4 mg/ml
2109
Compatible
injection Ketamine hydrochloride 25 mg/ml
injection Lormetazepam 0.12 mg/ml
Sodium chloride 0,9% 3705
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Magnesium sulfate 500 mg/ml
2109
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Meropenem 50 mg/ml
Water for Injection 4319
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Meropenem 50 mg/ml
2109
Immediate precipitation Incompatible
injection Ketamine hydrochloride
injection Methohexital sodium
3501
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Methylprednisolone acetate 62.5 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Metoclopramide hydrochloride 5 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Metronidazole 5 mg/ml
2109
Compatible
injection Ketamine hydrochloride 25 mg/ml
injection Midazolam hydrochloride 3.6 mg/ml
Sodium chloride 0,9% 3705
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Midazolam hydrochloride 5 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Milrinone lactate 1 mg/ml
2109
Compatible
injection Ketamine hydrochloride 2 mg/ml
injection Morphine sulfate 2 >> 10 mg/ml
Sodium chloride 0,9% 2322
Compatible
injection Ketamine hydrochloride 41,2 mg/ml
injection Morphine tartrate 57,8 mg/ml
Sodium chloride 0,9% 1864
Compatible
injection Ketamine hydrochloride 27,7 mg/ml
injection Morphine tartrate 57,8 mg/ml
Sodium chloride 0,9% 1864
Compatible
injection Ketamine hydrochloride 10 mg/ml
injection Morphine tartrate 24 mg/ml
Sodium chloride 0,9% 980
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Naloxone hydrochloride 0.4 mg/ml
None 3408
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Naloxone hydrochloride 0.4 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Nicardipine hydrochloride 0,2 mg/ml
4389
Immediate turbidity Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Nitroglycerin 5 mg/ml
2109
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Nitroglycerin 5 mg/ml
4389
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Norepinephrine bitartrate 1 mg/ml
4389
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Ondansetron hydrochloride 2 mg/ml
4389
Compatible
injection Ketamine hydrochloride 4 mg/ml
injection Oxycodone hydrochloride 1 mg/ml
Sodium chloride 0,9% 4842
Compatible
injection Ketamine hydrochloride 0.1 & 40 mg/ml
injection Oxycodone hydrochloride 0.4 & 10 mg/ml
Sodium chloride 0,9% 4143
Compatible
injection Ketamine hydrochloride 23.5 & 44.4 mg/ml
injection Oxycodone hydrochloride 14.7 & 38.5 mg/ml
Sodium chloride 0,9% 2900
Compatible
injection Ketamine hydrochloride 23.5 & 44.4 mg/ml
injection Oxycodone hydrochloride 14.7 & 38.5 mg/ml
Water for Injection 2900
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Oxytocin 10 UI/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Pancuronium bromide 2 mg/ml
2109
Compatible
injection Ketamine hydrochloride 5 mg/ml
injection Paracetamol 10 mg/ml
Glucose 5% 4435
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Paracetamol 10 mg/ml
4742
Immediate precipitation Incompatible
injection Ketamine hydrochloride
injection Pentobarbital sodium
3501
Compatible
injection Ketamine hydrochloride 2 mg/ml
injection Pethidine hydrochloride 12 mg/ml
Sodium chloride 0,9% 321
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Pethidine hydrochloride 100 mg/ml
2109
Immediate precipitation Incompatible
injection Ketamine hydrochloride
injection Phenobarbital sodium
3501
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Phenytoin sodium 50 mg/ml
2109
Unspecified incompatibility Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Piperacillin sodium 200 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Piperacillin sodium 200 mg/ml
4389
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Piperacillin sodium / tazobactam 200 mg/ml
2109
Compatible
injection Ketamine hydrochloride 25 mg/ml
injection Piritramide 1 mg/ml
Sodium chloride 0,9% 3705
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Potassium chloride 2000 mEq/l
2109
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Potassium phosphate 4 mmol/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Promethazine hydrochloride 25 mg/ml
2109
Compatible
injection Ketamine hydrochloride 10 mg/ml
injection Propofol 10 mg/ml
None 2329
Compatible
injection Ketamine hydrochloride 3.3 mg/ml
injection Propofol 6.7 mg/ml
None 2329
Compatible
injection Ketamine hydrochloride 10 mg/ml
injection Propofol 10 mg/ml
None 300
Compatible
injection Ketamine hydrochloride 2.3 >> 22.7 mg/ml
injection Propofol 1.8 >> 18.2 mg/ml
None 4011
Compatible
injection Ketamine hydrochloride 1.45 >> 3.7 mg/ml
injection Propofol 9.26 >> 9.6 mg/ml
None 4157
Instability of the emulsion after 6 hours Incompatible
injection Ketamine hydrochloride 10 mg/ml
injection Propofol
660
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Ranitidine hydrochloride 25 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Salbutamol sulfate 1 mg/ml
4389
Immediate turbidity Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Salbutamol sulfate 1 mg/ml
2109
Immediate precipitation Incompatible
injection Ketamine hydrochloride 50 mg/ml
injection Sodium bicarbonate 84 mg/ml
2109
Precipitation after 30 minutes Incompatible
injection Ketamine hydrochloride 25 mg/ml
injection Sodium oxybate 200 mg/ml
Sodium chloride 0,9% 3705
Compatible
injection Ketamine hydrochloride 25 mg/ml
injection Sufentanil citrate 0.03 mg/ml
Sodium chloride 0,9% 3705
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Sufentanil citrate 0,05 mg/ml
4389
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Sugammadex 100 mg/ml
None 3372
Compatible
injection Ketamine hydrochloride 10 mg/ml
injection Temocilline 83.33 mg/ml
Water for Injection 2231
Immediate precipitation Incompatible
injection Ketamine hydrochloride
injection Thiopental sodium
3501
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Tobramycin sulfate 40 mg/ml
2109
Compatible
injection Ketamine hydrochloride 0.5 >> 2 mg/ml
injection Tramadol hydrochloride 5 mg/ml
Sodium chloride 0,9% 365
Compatible
injection Ketamine hydrochloride 10 mg/ml
injection Vancomycin hydrochloride 10 mg/ml
Glucose 5% 3385
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Vancomycin hydrochloride 50 mg/ml
2109
Compatible
injection Ketamine hydrochloride 50 mg/ml
injection Vasopressin 20 UI/ml
4389

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