Last update :
18/06/2021
References   References 4578  
Type : Thesis
Web link : http://www.applis.univ-tours.fr/theses/2011/renaud.respaud_4309.pdf

Research teams : Tours - Faculté de pharmacie, Innovation moléculaire et thérapeutique
Authors : Respaud R.
Title : Etude de stabilité de médicaments anticancéreux injectables : apports analytiques et pharmaceutiques
Reference : 2011

Level of Evidence : 
Level of evidence A
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
High Performance Liquid Chromatography - Evaporative Light Scattering detector (HPLC-ELSD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products identified and quantified

List of drugs
InjectionMethotrexate sodium Anticancer drug
Stability in solutions Polypropylen Syringe None 25 & 100 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Polypropylen Syringe None 25 & 100 mg/ml 21°C Protect from light
14 Day
InjectionPemetrexed disodium Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 25 mg/ml 2-8°C Protect from light
14 Day
Stability in solutions Glass Sodium chloride 0,9% 25 mg/ml 22°C Protect from light
14 Day

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