Last update :
18/07/2024
References   References 4434  
Type : Journal
Web link : https://doi.org/10.1016/j.clinthera.2019.08.005

Research teams : Hartford - Center for Anti-Infective Research and Development
Authors : Avery L.M, Chen, I.H, Reyes, S, Nicolau, D.P, Kuti J.L.
Title : Assessment of the Physical Compatibility of Eravacycline and Common Parenteral Drugs During Simulated Y-site Administration.
Reference : Clin Ther ; 41, 10: 2162-2170. 2019

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAmiodarone hydrochloride Anti-arrhythmic
Incompatible 2 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionAztreonam Antibiotic
Compatible 20 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionBumetanide Diuretic
Compatible 0,25 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionCalcium chloride Electrolyte
Compatible 20 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionCalcium gluconate Electrolyte
Compatible 20 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionCefepime dihydrochloride Antibiotic
Compatible 40 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionCeftaroline fosamil Antibiotic
Incompatible 12 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionCeftazidime Antibiotic
Compatible 40 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionCeftazidime Avibactam Antibiotic
Compatible 40/10 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionCeftolozane / tazobactam Antibiotic
Compatible 20/10 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionCiprofloxacin lactate Antibiotic
Compatible 2 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionCisatracurium besylate Curarimimetic
Compatible 0,4 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionColistin mesilate sodium Antibiotic
Incompatible 4,5 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionDexmedetomidine Sympathomimetic
Compatible 4 µg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionDiltiazem hydrochloride Anti-arrhythmic
Compatible 5 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionDobutamine hydrochloride Cardiotonic
Compatible 4,1 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionDopamine hydrochloride Cardiotonic
Compatible 0,8 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 16 µg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionEravacycline Antibiotic
Compatible 0,6 mg/ml + Ringer’s lactate solution
Incompatible 0,6 mg/ml + injectionAmiodarone hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionAztreonam 20 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionBumetanide 0,25 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionCalcium chloride 20 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionCalcium gluconate 20 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionCefepime dihydrochloride 40 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + injectionCeftaroline fosamil 12 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionCeftazidime 40 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionCeftazidime Avibactam 40/10 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionCeftolozane / tazobactam 20/10 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionCisatracurium besylate 0,4 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + injectionColistin mesilate sodium 4,5 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionDexmedetomidine 4 µg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionDiltiazem hydrochloride 5 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionDobutamine hydrochloride 4,1 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionDopamine hydrochloride 0,8 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionEpinephrine hydrochloride 16 µg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionEsmolol hydrochloride 10 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionFentanyl citrate 50 µg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionFluconazole 2 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + injectionFurosemide 3 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionGentamicin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionHeparin sodium 1000 UI/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + Glucose 5%
Incompatible 0,6 mg/ml + injectionHuman albumin 250 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionHydromorphone hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionImipenem - cilastatin sodium 5/5 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionInsulin 1 UI/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionLevofloxacine 5 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionLinezolid 2 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionMagnesium sulfate 100 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + injectionMeropenem 20 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + injectionMeropenem Vaborbactam 8/8 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionMetronidazole 5 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + injectionMicafungin 4 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionMidazolam hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionMorphine sulfate 1 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionNicardipine hydrochloride 0,1 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionNorepinephrine bitartrate 0,032 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionOctreotide acetate 0,004 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionPantoprazole sodium 0,4 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionPhenylephrine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + injectionPropofol 10 mg/ml + Sodium chloride 0,9%
Incompatible 0,6 mg/ml + injectionSodium bicarbonate 84 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionTobramycin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionVancomycin hydrochloride 5 mg/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionVasopressin 1 UI/ml + Sodium chloride 0,9%
Compatible 0,6 mg/ml + injectionVecuronium bromide 1 mg/ml + Sodium chloride 0,9%
injectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionFentanyl citrate Analgesic
Compatible 50 µg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionFurosemide Diuretic
Incompatible 3 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionGentamicin sulfate Antibiotic
Compatible 5 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionHeparin sodium Anticoagulant
Compatible 1000 UI/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionHuman albumin Various
Incompatible 250 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionHydromorphone hydrochloride Analgesic
Compatible 1 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionImipenem - cilastatin sodium Antibiotic
Compatible 5/5 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionInsulin Glucose-lowering
Compatible 1 UI/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionLevofloxacine Antibiotic
Compatible 5 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionLinezolid Antibiotic
Compatible 2 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionMeropenem Antibiotic
Incompatible 20 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionMeropenem Vaborbactam Antibiotic
Incompatible 8/8 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionMicafungin Antifungal
Incompatible 4 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionMidazolam hydrochloride Anxiolytic
Compatible 1 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionMorphine sulfate Analgesic
Compatible 1 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionNicardipine hydrochloride Vasodilator
Compatible 0,1 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 0,032 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionOctreotide acetate Various
Compatible 0,004 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionPantoprazole sodium Proton pump inhibitor
Compatible 0,4 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionPhenylephrine hydrochloride Sympathomimetic
Compatible 1 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionPiperacillin sodium / tazobactam Antibiotic
Compatible 40/5 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionPropofol General anesthetic
Incompatible 10 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionSodium bicarbonate Electrolyte
Incompatible 84 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionTobramycin sulfate Antibiotic
Compatible 5 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionVancomycin hydrochloride Antibiotic
Compatible 5 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionVasopressin Hormone
Compatible 1 UI/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%
injectionVecuronium bromide Curarimimetic
Compatible 1 mg/ml + injectionEravacycline 0,6 mg/ml + Sodium chloride 0,9%

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