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References   References 251  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/54/23/2708
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Gilbert DL, Martinez JF.
Title : Compatibility of doxorubicin hydrochloride liposome injection with selected other drugs during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ; 54: 2708-2713. 1997
Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only
List of drugs
injectionAciclovir sodium Antiviral
Compatible 7 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionAllopurinol sodium Antigout
Compatible 3 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionAminophylline Various
Compatible 2.5 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionAmphotericin B Antifungal
Incompatible 0.6 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionAmpicillin sodium Antibiotic
Compatible 20 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionAztreonam Antibiotic
Compatible 40 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionBleomycin sulfate Anticancer drug
Compatible 1 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionBuprenorphine hydrochloride Analgesic
Incompatible 0.04 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionButorphanol tartrate Analgesic
Compatible 0.04 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCalcium gluconate Electrolyte
Compatible 40 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCarboplatin Anticancer drug
Compatible 5 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCefazolin sodium Antibiotic
Compatible 20 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCefepime dihydrochloride Antibiotic
Compatible 20 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCefoperazone sodium Antibiotic
Incompatible 40 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCefoxitin sodium Antibiotic
Compatible 20 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCeftazidime Antibiotic
Incompatible 40 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCeftizoxime sodium Antibiotic
Compatible 20 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCeftriaxone disodium Antibiotic
Compatible 20 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionChlorpromazine hydrochloride Anxiolytic
Compatible 2 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCiprofloxacin lactate Antibiotic
Compatible 1 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCisplatin Anticancer drug
Compatible 1 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCo-trimoxazole Antibiotic
Compatible 0.8/4 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCyclophosphamide Anticancer drug
Compatible 10 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionCytarabine Anticancer drug
Compatible 50 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionDacarbazine Anticancer drug
Compatible 4 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionDobutamine hydrochloride Cardiotonic
Compatible 4 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionDocetaxel Anticancer drug
Incompatible 2 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionDopamine hydrochloride Cardiotonic
Compatible 3.2 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionDoxorubicin hydrochloride liposome peg Anticancer drug
Factors which affect stability Solvent NaHCO3 Induces Degradation
Incompatible + NaHCO3
Compatible 0.4 mg/ml + injectionAciclovir sodium 7 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionAllopurinol sodium 3 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionAminophylline 2.5 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionAmphotericin B 0.6 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionAmpicillin sodium 20 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionAztreonam 40 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionBleomycin sulfate 1 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionBuprenorphine hydrochloride 0.04 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionButorphanol tartrate 0.04 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionCalcium gluconate 40 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionCarboplatin 5 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionCefazolin sodium 20 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionCefepime dihydrochloride 20 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionCefoperazone sodium 40 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionCefoxitin sodium 20 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionCeftazidime 40 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionCeftizoxime sodium 20 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionCeftriaxone disodium 20 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionChlorpromazine hydrochloride 2 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionCimetidine hydrochloride 12 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionCiprofloxacin lactate 1 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionCisplatin 1 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionClindamycin phosphate 10 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionCo-trimoxazole 0.8/4 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionCyclophosphamide 10 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionCytarabine 50 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionDacarbazine 4 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionDiphenhydramine hydrochloride 2 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionDobutamine hydrochloride 4 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionDocetaxel 2 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionDopamine hydrochloride 3.2 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionDroperidol 0.4 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionEnalaprilate 0.1 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionEtoposide 0.4 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionFamotidine 2 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionFluconazole 2 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionFluorouracil 16 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionFolinate calcium 2 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionFurosemide 3 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionGallium nitrate 0.4 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionGanciclovir sodium 20 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionGentamicin sulfate 5 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionGranisetron hydrochloride 0.05 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionHaloperidol lactate 0.2 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionHeparin sodium 1000 UI/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionHydrocortisone sodium succinate 1 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionHydromorphone hydrochloride 0.5 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionHydroxyzine dihydrochloride 2 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionIfosfamide 25 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionLorazepam 0.1 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionMagnesium sulfate 100 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionMannitol 150 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionMesna 10 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionMethotrexate sodium 15 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionMethylprednisolone sodium succinate 5 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionMetoclopramide hydrochloride 5 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionMetronidazole 5 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionMitoxantrone dihydrochloride 0.5 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionMorphine sulfate 1 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionNetilmicin sulfate 5 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionOfloxacin 4 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionOndansetron hydrochloride 1 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionPaclitaxel 0.6 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionPethidine hydrochloride 4 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionPiperacillin sodium 40 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionPotassium chloride 100 mEq/l + Glucose 5%
Compatible 0.4 mg/ml + injectionProchlorperazine edysilate 0.5 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionPromethazine hydrochloride 2 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionRanitidine hydrochloride 2 mg/ml + Glucose 5%
Incompatible 0.4 mg/ml + injectionSodium bicarbonate 84 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionTicarcillin / clavulanic acid 31 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionTobramycin sulfate 5 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionVancomycin hydrochloride 10 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionVinblastine sulfate 0.12 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionVincristine sulfate 0.05 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionVinorelbine tartrate 1 mg/ml + Glucose 5%
Compatible 0.4 mg/ml + injectionZidovudine 4 mg/ml + Glucose 5%
injectionDroperidol Neuroleptic
Compatible 0.4 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionEnalaprilate Antihypertensive
Compatible 0.1 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionEtoposide Anticancer drug
Compatible 0.4 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionFamotidine Antihistamine (H2)
Compatible 2 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionFluorouracil Anticancer drug
Compatible 16 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionFolinate calcium Cytoprotective
Compatible 2 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionFurosemide Diuretic
Compatible 3 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionGallium nitrate Calcium-lowering agent
Incompatible 0.4 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionGanciclovir sodium Antiviral
Compatible 20 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionGentamicin sulfate Antibiotic
Compatible 5 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionGranisetron hydrochloride Antiemetic
Compatible 0.05 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionHaloperidol lactate Neuroleptic
Compatible 0.2 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionHeparin sodium Anticoagulant
Compatible 1000 UI/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionHydroxyzine dihydrochloride Anxiolytic
Incompatible 2 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionIfosfamide Anticancer drug
Compatible 25 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionLorazepam Anxiolytic
Compatible 0.1 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionMannitol Various
Incompatible 150 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionMesna Cytoprotective
Compatible 10 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionMethotrexate sodium Anticancer drug
Compatible 15 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 5 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionMetoclopramide hydrochloride Antiemetic
Incompatible 5 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionMitoxantrone dihydrochloride Anticancer drug
Incompatible 0.5 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionMorphine sulfate Analgesic
Incompatible 1 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionNetilmicin sulfate Antibiotic
Compatible 5 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionOfloxacin Antibiotic
Incompatible 4 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionOndansetron hydrochloride Antiemetic
Compatible 1 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionPaclitaxel Anticancer drug
Incompatible 0.6 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionPethidine hydrochloride Analgesic
Incompatible 4 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionPiperacillin sodium Antibiotic
Compatible 40 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionPiperacillin sodium / tazobactam Antibiotic
Incompatible 40/5 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionPotassium chloride Electrolyte
Compatible 100 mEq/l + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionProchlorperazine edysilate Neuroleptic
Compatible 0.5 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionPromethazine hydrochloride Antihistamine (H1)
Incompatible 2 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionSodium bicarbonate Electrolyte
Incompatible 84 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionTicarcillin / clavulanic acid Antibiotic
Compatible 31 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionTobramycin sulfate Antibiotic
Compatible 5 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionVancomycin hydrochloride Antibiotic
Compatible 10 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionVinblastine sulfate Anticancer drug
Compatible 0.12 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionVincristine sulfate Anticancer drug
Compatible 0.05 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionVinorelbine tartrate Anticancer drug
Compatible 1 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
injectionZidovudine Antiviral
Compatible 4 mg/ml + injectionDoxorubicin hydrochloride liposome peg 0.4 mg/ml + Glucose 5%
  Mentions Légales