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References   References 813  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/56/1/63
Research teams : Decatur - Emory University System of Health Care
Authors : Akkermann SR, Zhang H, Mullins RE, Yaughn K.
Title : Stability of milrinone lactate in the presence of 29 critical care drugs and 4 IV solutions.
Reference : Am J Health-Syst Pharm ; 56: 63-68. 1999
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionAtracurium besylate Curarimimetic
Compatible 2 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionBumetanide Diuretic
Compatible 0.5 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionCalcium gluconate Electrolyte
Compatible 200 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionDiltiazem hydrochloride Anti-arrhythmic
Compatible 2 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionDobutamine hydrochloride Cardiotonic
Compatible 16 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionDopamine hydrochloride Cardiotonic
Compatible 12.8 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 128 µg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionFentanyl citrate Analgesic
Compatible 100 µg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionHeparin sodium Anticoagulant
Compatible 200 UI/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionInsulin Glucose-lowering
Compatible 2 UI/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0.016 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionLorazepam Anxiolytic
Compatible 0.4 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionMagnesium sulfate Electrolyte
Compatible 80 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionMidazolam hydrochloride Anxiolytic
Compatible 2 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionMilrinone lactate Cardiotonic
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,4 mg/ml 22°C-23°C Light
7 Day
Stability in solutions Polyvinyl chloride Glucose 5% 0,4 mg/ml 22°C-23°C Light
7 Day
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 0,4 mg/ml 22°C-23°C Light
7 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,45% 0,4 mg/ml 22°C-23°C Light
7 Day
Compatible 0.8 mg/ml + Parenteral nutrition (binary mixture)
Compatible 0.8 mg/ml + injectionAtracurium besylate 2 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionBumetanide 0.5 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionCalcium gluconate 200 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionCimetidine hydrochloride 12 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionDiltiazem hydrochloride 2 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionDobutamine hydrochloride 16 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionDopamine hydrochloride 12.8 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionEpinephrine hydrochloride 128 µg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionFentanyl citrate 100 µg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionHeparin sodium 200 UI/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionInsulin 2 UI/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionIsoprenaline hydrochloride 0.016 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionLorazepam 0.4 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionMagnesium sulfate 80 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionMidazolam hydrochloride 2 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionMorphine sulfate 2 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionNitroglycerin 1.6 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionNitroprusside sodium 1.6 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionNorepinephrine bitartrate 0.128 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionPancuronium bromide 2 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionPotassium chloride 2000 mEq/l + Glucose 5%
Compatible 0.8 mg/ml + injectionPropofol 20 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionRanitidine hydrochloride 4 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionRocuronium bromide 4 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionSodium bicarbonate 168 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionTheophylline 3.2 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionTorsemide 20 mg/ml + Glucose 5%
Compatible 0.8 mg/ml + injectionVecuronium bromide 2 mg/ml + Glucose 5%
injectionMorphine sulfate Analgesic
Compatible 2 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionNitroglycerin Vasodilator
Compatible 1.6 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionNitroprusside sodium Vasodilator
Compatible 1.6 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 0.128 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionPancuronium bromide Curarimimetic
Compatible 2 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionPotassium chloride Electrolyte
Compatible 2000 mEq/l + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionPropofol General anesthetic
Compatible 20 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 4 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionRocuronium bromide Curarimimetic
Compatible 4 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionSodium bicarbonate Electrolyte
Compatible 168 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionTheophylline Various
Compatible 3.2 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionTorsemide Diuretic
Compatible 20 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
injectionVecuronium bromide Curarimimetic
Compatible 2 mg/ml + injectionMilrinone lactate 0.8 mg/ml + Glucose 5%
Stability of mixtures
Glass Sodium chloride 0,9% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Insulin 0,8 UI/ml
4 Hour
Glass Glucose 5% 22°C-23°C Protect from light
injection Milrinone lactate 0,2 mg/ml
injection Nitroprusside sodium 0,4 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Nitroglycerin 0,4 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Dopamine hydrochloride 3,1 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Dobutamine hydrochloride 4 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Epinephrine hydrochloride 0,03 µg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Norepinephrine bitartrate 0,03 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Ranitidine hydrochloride 0,85 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Cimetidine hydrochloride 2,9 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Pancuronium bromide 0,46 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Atracurium besylate 0,5 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Diltiazem hydrochloride 0,5 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Bumetanide 0,12 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Theophylline 0,89 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Propofol 5,3 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Heparin sodium 59 UI/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Morphine sulfate 0,5 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Lorazepam 0,1 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Midazolam hydrochloride 0,5 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Fentanyl citrate 25 µg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Isoprenaline hydrochloride 3,7 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Vecuronium bromide 0,52 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
injection Milrinone lactate 0,2 mg/ml
injection Rocuronium bromide 1 mg/ml
4 Hour
  Mentions Légales