Last update :
27/11/2024
References   References 69  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/43/11/2810

Research teams : Palo Alto - Syntex Research
Authors : Visor GC, Lin LH, Jackson SE, Winterle JS, Lee G, Kenley RA.
Title : Stability of ganciclovir sodium (DHPG sodium) in 5% dextrose or 0.9% sodium chloride injections.
Reference : Am J Hosp Pharm ; 43: 2810-2812. 1986

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Changes in pH not commented or difficult to interpret
Degradation products not observed in real conditions

List of drugs
injectionGanciclovir sodium Antiviral
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 2.5 mg/ml 25°C Protect from light
5 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 2.5 mg/ml 4°C Protect from light
5 Day

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