Last update :
06/05/2024
References   References 186  
Type : Journal

Research teams : Amsterdam - Free University Hospital, Department of Pharmacy
Authors : Swart EL, Mooren RAG, Van Loenen AC.
Title : Compatibility of midazolam hydrochloride and lorazepam with selected drugs during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ; 52: 2020-2022. 1995

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionAmoxicillin sodium Antibiotic
Compatible 50 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 50 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionAmoxicillin sodium / clavulanic acid Antibiotic
Compatible 20/2 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 20/2 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionBumetanide Diuretic
Compatible 0.5 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 0.5 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionCefotaxime sodium Antibiotic
Compatible 10 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionCiprofloxacin lactate Antibiotic
Compatible 2 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionClonidine hydrochloride Antihypertensive
Compatible 0.015 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 0.015 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionCo-trimoxazole Antibiotic
Compatible 0.8/4 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 0.8/4 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 4 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionErythromycin lactobionate Antibiotic
Compatible 5 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionFentanyl citrate Analgesic
Compatible 50 µg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 50 µg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionFlucloxacillin sodium Antibiotic
Incompatible 50 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 50 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionFluconazole Antifungal
Compatible 2 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionFurosemide Diuretic
Compatible 10 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 10 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionGentamicin sulfate Antibiotic
Compatible 3 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 3 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionHaloperidol lactate Neuroleptic
Compatible 0.5 & 5 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 0.5 & 5 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionHeparin sodium Anticoagulant
Compatible 417 UI/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 417 UI/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionHuman albumin Various
Compatible 200 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 200 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 50 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 50 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionImipenem - cilastatin sodium Antibiotic
Incompatible 5 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 5 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionLorazepam Anxiolytic
Compatible 0.33 mg/ml + InjectionAmikacin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionAmoxicillin sodium 50 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionAmoxicillin sodium / clavulanic acid 20/2 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionBumetanide 0.5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionCefotaxime sodium 10 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionCiprofloxacin lactate 2 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionClonidine hydrochloride 0.015 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionCo-trimoxazole 0.8/4 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionDexamethasone sodium phosphate 4 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionErythromycin lactobionate 5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionFentanyl citrate 50 µg/ml + Sodium chloride 0,9%
Incompatible 0.33 mg/ml + InjectionFlucloxacillin sodium 50 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionFluconazole 2 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionFurosemide 10 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionGentamicin sulfate 3 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionHaloperidol lactate 0.5 & 5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionHeparin sodium 417 UI/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionHuman albumin 200 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionHydrocortisone sodium succinate 50 mg/ml + Sodium chloride 0,9%
Incompatible 0.33 mg/ml + InjectionImipenem - cilastatin sodium 5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionMetronidazole 5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionMorphine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 0.33 mg/ml + InjectionOmeprazole sodium 4 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionPiperacillin sodium 150 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionPotassium chloride 1000 mEq/l + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionRanitidine hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionVancomycin hydrochloride 5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + InjectionVecuronium bromide 4 mg/ml + Sodium chloride 0,9%
InjectionMetronidazole Antiparasitic
Compatible 5 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionMidazolam hydrochloride Anxiolytic
Factors which affect stability PH PH > 5 Induces Precipitation
Compatible 5 mg/ml + InjectionAmikacin sulfate 5 mg/ml + None
Incompatible 5 mg/ml + InjectionAmoxicillin sodium 50 mg/ml + None
Incompatible 5 mg/ml + InjectionAmoxicillin sodium / clavulanic acid 20/2 mg/ml + None
Incompatible 5 mg/ml + InjectionBumetanide 0.5 mg/ml + None
Compatible 5 mg/ml + InjectionCefotaxime sodium 10 mg/ml + None
Compatible 5 mg/ml + InjectionCiprofloxacin lactate 2 mg/ml + None
Incompatible 5 mg/ml + InjectionClonidine hydrochloride 0.015 mg/ml + None
Incompatible 5 mg/ml + InjectionCo-trimoxazole 0.8/4 mg/ml + None
Incompatible 5 mg/ml + InjectionDexamethasone sodium phosphate 4 mg/ml + None
Compatible 5 mg/ml + InjectionErythromycin lactobionate 5 mg/ml + None
Compatible 5 mg/ml + InjectionFentanyl citrate 50 µg/ml + None
Incompatible 5 mg/ml + InjectionFlucloxacillin sodium 50 mg/ml + None
Compatible 5 mg/ml + InjectionFluconazole 2 mg/ml + None
Incompatible 5 mg/ml + InjectionFurosemide 10 mg/ml + None
Compatible 5 mg/ml + InjectionGentamicin sulfate 3 mg/ml + None
Compatible 5 mg/ml + InjectionHaloperidol lactate 0.5 & 5 mg/ml + None
Compatible 5 mg/ml + InjectionHeparin sodium 417 UI/ml + None
Incompatible 5 mg/ml + InjectionHuman albumin 200 mg/ml + None
Incompatible 5 mg/ml + InjectionHydrocortisone sodium succinate 50 mg/ml + None
Incompatible 5 mg/ml + InjectionImipenem - cilastatin sodium 5 mg/ml + None
Compatible 5 mg/ml + InjectionMetronidazole 5 mg/ml + None
Compatible 5 mg/ml + InjectionMorphine hydrochloride 1 mg/ml + None
Incompatible 5 mg/ml + InjectionOmeprazole sodium 4 mg/ml + None
Compatible 5 mg/ml + InjectionPiperacillin sodium 150 mg/ml + None
Compatible 5 mg/ml + InjectionPotassium chloride 1000 mEq/l + None
Compatible 5 mg/ml + InjectionRanitidine hydrochloride 0.5 mg/ml + None
Compatible 5 mg/ml + InjectionVancomycin hydrochloride 5 mg/ml + None
Compatible 5 mg/ml + InjectionVecuronium bromide 4 mg/ml + None
InjectionMorphine hydrochloride Analgesic
Compatible 1 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionOmeprazole sodium Proton pump inhibitor
Incompatible 4 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionPiperacillin sodium Antibiotic
Compatible 150 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 150 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionPotassium chloride Electrolyte
Compatible 1000 mEq/l + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 1000 mEq/l + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionRanitidine hydrochloride Antihistamine (H2)
Compatible 0.5 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 0.5 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionVancomycin hydrochloride Antibiotic
Compatible 5 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None
InjectionVecuronium bromide Curarimimetic
Compatible 4 mg/ml + InjectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 4 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + None

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