Last update :
19/11/2024
References   References 285  
Type : Journal

Research teams : West Haven - Bayer Corporation, Pharmaceutical Division
Authors : Elmore RL, Contois ME, Kelly J, Noe A, Poirier A.
Title : Stability and compatibility of admixtures of intravenous ciprofloxacin and selected drugs.
Reference : Clin Ther ; 18: 246-255. 1996

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
injectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionAmphotericin B Antifungal
Incompatible 0.1 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionAmpicillin sodium - sulbactam sodium Antibiotic
Incompatible 30 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionAtracurium besylate Curarimimetic
Compatible 2 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionAztreonam Antibiotic
Compatible 40 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionCeftazidime Antibiotic
Incompatible 20 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionCefuroxime sodium Antibiotic
Incompatible 30 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 1.2 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionCiprofloxacin lactate Antibiotic
Factors which affect stability Solvent NaHCO3 Induces Degradation
Compatible 2 mg/ml + injectionAmikacin sulfate 5 mg/ml + Glucose 5%
Incompatible 2 mg/ml + injectionAmphotericin B 0.1 mg/ml + Glucose 5%
Incompatible 2 mg/ml + injectionAmpicillin sodium - sulbactam sodium 30 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionAtracurium besylate 2 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionAztreonam 40 mg/ml + Glucose 5%
Incompatible 2 mg/ml + injectionCeftazidime 20 mg/ml + Glucose 5%
Incompatible 2 mg/ml + injectionCefuroxime sodium 30 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionCimetidine hydrochloride 1.2 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionDobutamine hydrochloride 2 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionFluconazole 1 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionGentamicin sulfate 1.6 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionMetronidazole 2.5 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionMidazolam hydrochloride 0.2 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionNorepinephrine bitartrate 0.064 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionPancuronium bromide 0.2 mg/ml + Glucose 5%
Incompatible 2 mg/ml + injectionPiperacillin sodium 40 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionPotassium chloride 40 mEq/l + Glucose 5%
Incompatible 2 mg/ml + injectionSodium bicarbonate 4 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionTicarcillin / clavulanic acid 30 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionTobramycin sulfate 1.6 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionVecuronium bromide 0.2 mg/ml + Glucose 5%
Incompatible + NaHCO3
injectionDobutamine hydrochloride Cardiotonic
Compatible 2 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionFluconazole Antifungal
Compatible 1 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionGentamicin sulfate Antibiotic
Compatible 1.6 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionMetronidazole Antiparasitic
Compatible 2.5 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionMidazolam hydrochloride Anxiolytic
Compatible 0.2 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 0.064 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionPancuronium bromide Curarimimetic
Compatible 0.2 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionPiperacillin sodium Antibiotic
Incompatible 40 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionPotassium chloride Electrolyte
Compatible 40 mEq/l + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionSodium bicarbonate Electrolyte
Incompatible 4 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionTicarcillin / clavulanic acid Antibiotic
Compatible 30 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionTobramycin sulfate Antibiotic
Compatible 1.6 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%
injectionVecuronium bromide Curarimimetic
Compatible 0.2 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Glucose 5%

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