Last update :
19/11/2024
References   References 1900  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=1800

Research teams : Athens - University of Georgia, College of Pharmacy
Authors : Musami P, Stewart JT, Taylor EW.
Title : Stability of zidovudine and ranitidine in 0.9% sodium chloride and 5% dextrose injections stored at ambient temperature (23°C±2°C) and 4°C in 50 ml polyvinylchloride bags up to 24 hours.
Reference : Int J Pharm Compound ; 8, 3: 236-239. 2004

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No visual inspection
Degradation products not observed in real conditions
Changes in pH not commented or difficult to interpret
Repeatability / reproducibility / standard range: results not provided or results outside specified values

List of drugs
injectionRanitidine hydrochloride Antihistamine (H2)
injectionZidovudine Antiviral
Stability of mixtures
Polyvinyl chloride NaCl 0,9% or Glucose 5% 23°C Light
injection Zidovudine 2 mg/ml
injection Ranitidine hydrochloride 0,5 mg/ml
24 Hour
Polyvinyl chloride NaCl 0,9% or Glucose 5% 4°C Protect from light
injection Zidovudine 2 mg/ml
injection Ranitidine hydrochloride 0,5 mg/ml
24 Hour

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