Last update :
04/10/2024
References   References 186  
Type : Journal

Research teams : Amsterdam - Free University Hospital, Department of Pharmacy
Authors : Swart EL, Mooren RAG, Van Loenen AC.
Title : Compatibility of midazolam hydrochloride and lorazepam with selected drugs during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ; 52: 2020-2022. 1995

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionAmoxicillin sodium Antibiotic
Compatible 50 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 50 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionAmoxicillin sodium / clavulanic acid Antibiotic
Compatible 20/2 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 20/2 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionBumetanide Diuretic
Compatible 0.5 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 0.5 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionCefotaxime sodium Antibiotic
Compatible 10 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 10 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionCiprofloxacin lactate Antibiotic
Compatible 2 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionClonidine hydrochloride Antihypertensive
Compatible 0.015 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 0.015 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionCo-trimoxazole Antibiotic
Compatible 0.8/4 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 0.8/4 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 4 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionErythromycin lactobionate Antibiotic
Compatible 5 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionFentanyl citrate Analgesic
Compatible 50 µg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 50 µg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionFlucloxacillin sodium Antibiotic
Incompatible 50 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 50 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionFurosemide Diuretic
Compatible 10 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 10 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionGentamicin sulfate Antibiotic
Compatible 3 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 3 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionHaloperidol lactate Neuroleptic
Compatible 0.5 & 5 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 0.5 & 5 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionHeparin sodium Anticoagulant
Compatible 417 UI/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 417 UI/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionHuman albumin Various
Compatible 200 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 200 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 50 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 50 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionImipenem - cilastatin sodium Antibiotic
Incompatible 5 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 5 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionLorazepam Anxiolytic
Compatible 0.33 mg/ml + injectionAmikacin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionAmoxicillin sodium 50 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionAmoxicillin sodium / clavulanic acid 20/2 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionBumetanide 0.5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionCefotaxime sodium 10 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionClonidine hydrochloride 0.015 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionCo-trimoxazole 0.8/4 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionDexamethasone sodium phosphate 4 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionErythromycin lactobionate 5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionFentanyl citrate 50 µg/ml + Sodium chloride 0,9%
Incompatible 0.33 mg/ml + injectionFlucloxacillin sodium 50 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionFluconazole 2 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionFurosemide 10 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionGentamicin sulfate 3 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionHaloperidol lactate 0.5 & 5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionHeparin sodium 417 UI/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionHuman albumin 200 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionHydrocortisone sodium succinate 50 mg/ml + Sodium chloride 0,9%
Incompatible 0.33 mg/ml + injectionImipenem - cilastatin sodium 5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionMetronidazole 5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionMorphine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Incompatible 0.33 mg/ml + injectionOmeprazole sodium 4 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionPiperacillin sodium 150 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionPotassium chloride 1000 mEq/l + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionRanitidine hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionVancomycin hydrochloride 5 mg/ml + Sodium chloride 0,9%
Compatible 0.33 mg/ml + injectionVecuronium bromide 4 mg/ml + Sodium chloride 0,9%
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionMidazolam hydrochloride Anxiolytic
Factors which affect stability pH pH > 5 Induces Precipitation
Compatible 5 mg/ml + injectionAmikacin sulfate 5 mg/ml + None
Incompatible 5 mg/ml + injectionAmoxicillin sodium 50 mg/ml + None
Incompatible 5 mg/ml + injectionAmoxicillin sodium / clavulanic acid 20/2 mg/ml + None
Incompatible 5 mg/ml + injectionBumetanide 0.5 mg/ml + None
Compatible 5 mg/ml + injectionCefotaxime sodium 10 mg/ml + None
Compatible 5 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + None
Incompatible 5 mg/ml + injectionClonidine hydrochloride 0.015 mg/ml + None
Incompatible 5 mg/ml + injectionCo-trimoxazole 0.8/4 mg/ml + None
Incompatible 5 mg/ml + injectionDexamethasone sodium phosphate 4 mg/ml + None
Compatible 5 mg/ml + injectionErythromycin lactobionate 5 mg/ml + None
Compatible 5 mg/ml + injectionFentanyl citrate 50 µg/ml + None
Incompatible 5 mg/ml + injectionFlucloxacillin sodium 50 mg/ml + None
Compatible 5 mg/ml + injectionFluconazole 2 mg/ml + None
Incompatible 5 mg/ml + injectionFurosemide 10 mg/ml + None
Compatible 5 mg/ml + injectionGentamicin sulfate 3 mg/ml + None
Compatible 5 mg/ml + injectionHaloperidol lactate 0.5 & 5 mg/ml + None
Compatible 5 mg/ml + injectionHeparin sodium 417 UI/ml + None
Incompatible 5 mg/ml + injectionHuman albumin 200 mg/ml + None
Incompatible 5 mg/ml + injectionHydrocortisone sodium succinate 50 mg/ml + None
Incompatible 5 mg/ml + injectionImipenem - cilastatin sodium 5 mg/ml + None
Compatible 5 mg/ml + injectionMetronidazole 5 mg/ml + None
Compatible 5 mg/ml + injectionMorphine hydrochloride 1 mg/ml + None
Incompatible 5 mg/ml + injectionOmeprazole sodium 4 mg/ml + None
Compatible 5 mg/ml + injectionPiperacillin sodium 150 mg/ml + None
Compatible 5 mg/ml + injectionPotassium chloride 1000 mEq/l + None
Compatible 5 mg/ml + injectionRanitidine hydrochloride 0.5 mg/ml + None
Compatible 5 mg/ml + injectionVancomycin hydrochloride 5 mg/ml + None
Compatible 5 mg/ml + injectionVecuronium bromide 4 mg/ml + None
injectionMorphine hydrochloride Analgesic
Compatible 1 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 1 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionOmeprazole sodium Proton pump inhibitor
Incompatible 4 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Incompatible 4 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionPiperacillin sodium Antibiotic
Compatible 150 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 150 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionPotassium chloride Electrolyte
Compatible 1000 mEq/l + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 1000 mEq/l + injectionMidazolam hydrochloride 5 mg/ml + None
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 0.5 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 0.5 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionVancomycin hydrochloride Antibiotic
Compatible 5 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 5 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
injectionVecuronium bromide Curarimimetic
Compatible 4 mg/ml + injectionLorazepam 0.33 mg/ml + Sodium chloride 0,9%
Compatible 4 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None

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