Last update :
23/11/2022
References   References 4643  
Type : Journal
Web link : 10.1136/ejhpharm-2021-002940

Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : Catry E, Colsoul M-L, Closset M, Nyssen C, Hubert J, Soumoy L, Bihin B, Jamart J, Hecq J-D, Galanti L.
Title : Evaluation of 30-day stability of morphine hydrochloride and clonidine at high and low concentrations in polypropylene syringes.
Reference : EJHP 2021

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values

List of drugs
InjectionClonidine hydrochloride Antihypertensive
InjectionMorphine hydrochloride Analgesic
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 2-8°C Not specified
Injection Morphine hydrochloride 0,417 mg/ml
Injection Clonidine hydrochloride 0,003 mg/ml
30 Day
Polypropylen Syringe Sodium chloride 0,9% 2-8°C Not specified
Injection Morphine hydrochloride 4,3 mg/ml
Injection Clonidine hydrochloride 0,032 mg/ml
30 Day

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