Last update :
19/11/2024
References   References 3766  
Type : Journal
Web link : http://www.pharmactuel.com/index.php/pharmactuel/issue/view/101

Research teams : Montreal - Centre hospitalier Sainte Justine
Authors : Forrest J.M, Hildgen P.
Title : Compatibilité de l’acétylcystéine injectable lors de son administration en Y avec d’autres médicaments usuels
Reference : Pharmactuel ; 47, 3 : 161-165. 2014

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
injectionAciclovir sodium Antiviral
Incompatible 50 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionAmikacin sulfate Antibiotic
Compatible 250 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionAminophylline Various
Incompatible 50 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionAmiodarone hydrochloride Anti-arrhythmic
Compatible 50 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionAmphotericin B Antifungal
Incompatible + injectionN-acetylcysteine 200 mg/ml + None
injectionAmpicillin sodium Antibiotic
Compatible + injectionN-acetylcysteine 200 mg/ml + None
injectionAtropine sulfate Antimuscarinic
Compatible 0.4 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionAzithromycine Antibiotic
Compatible 500 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionBretylium tosilate Anti-arrhythmic
Compatible 50 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionCaffeine Respiratory stimulant
Compatible 10 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionCalcium chloride Electrolyte
Compatible 78 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionCalcium gluconate Electrolyte
Compatible 100 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionCaspofungin acetate Antifungal
Compatible + injectionN-acetylcysteine 200 mg/ml + None
injectionCefazolin sodium Antibiotic
Incompatible + injectionN-acetylcysteine 200 mg/ml + None
injectionCefotaxime sodium Antibiotic
Compatible + injectionN-acetylcysteine 200 mg/ml + None
injectionCefoxitin sodium Antibiotic
Compatible + injectionN-acetylcysteine 200 mg/ml + None
injectionCeftazidime Antibiotic
Compatible + injectionN-acetylcysteine 200 mg/ml + None
injectionCeftriaxone disodium Antibiotic
Compatible + injectionN-acetylcysteine 200 mg/ml + None
injectionCefuroxime sodium Antibiotic
Incompatible + injectionN-acetylcysteine 200 mg/ml + None
injectionChlorpromazine hydrochloride Anxiolytic
Incompatible 25 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionCiclosporin Immunosuppressant
Incompatible 50 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionCiprofloxacin lactate Antibiotic
Compatible 2 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionClindamycin phosphate Antibiotic
Compatible 150 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionCloxacillin sodium Antibiotic
Incompatible + injectionN-acetylcysteine 200 mg/ml + None
injectionCo-trimoxazole Antibiotic
Compatible 16/80 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionDexamethasone sodium phosphate Anti-inflammatory
Incompatible 4 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionDiazepam Anxiolytic
Compatible 5 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionDigoxin Cardiotonic
Compatible 50 µg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 50 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionDobutamine hydrochloride Cardiotonic
Incompatible 12.5 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionDopamine hydrochloride Cardiotonic
Compatible 3.2 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionDroperidol Neuroleptic
Compatible 2.5 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionEnalaprilate Antihypertensive
Compatible 1.25 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionEpinephrine hydrochloride Sympathomimetic
Incompatible 1000 µg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionErythromycin lactobionate Antibiotic
Incompatible + injectionN-acetylcysteine 200 mg/ml + None
injectionFentanyl citrate Analgesic
Incompatible 50 µg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionFurosemide Diuretic
Compatible 10 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionGentamicin sulfate Antibiotic
Compatible 40 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionHeparin sodium Anticoagulant
Compatible 1000 UI/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionHydralazine hydrochloride Antihypertensive
Compatible + injectionN-acetylcysteine 200 mg/ml + None
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible + injectionN-acetylcysteine 200 mg/ml + None
injectionInsulin Glucose-lowering
Incompatible 100 UI/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionLabetalol hydrochloride Beta-blocker
Compatible 5 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionLidocaine hydrochloride Local anesthetic
Compatible 1 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionMannitol Various
Compatible 250 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionMetronidazole Antiparasitic
Incompatible 5 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionMidazolam hydrochloride Anxiolytic
Compatible 5 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionMilrinone lactate Cardiotonic
Compatible 1 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionN-acetylcysteine Antidote
Incompatible 200 mg/ml + injectionAciclovir sodium 50 mg/ml + None
Compatible 200 mg/ml + injectionAmikacin sulfate 250 mg/ml + None
Incompatible 200 mg/ml + injectionAminophylline 50 mg/ml + None
Compatible 200 mg/ml + injectionAmiodarone hydrochloride 50 mg/ml + None
Incompatible 200 mg/ml + injectionAmphotericin B + None
Compatible 200 mg/ml + injectionAmpicillin sodium + None
Compatible 200 mg/ml + injectionAtropine sulfate 0.4 mg/ml + None
Compatible 200 mg/ml + injectionAzithromycine 500 mg/ml + None
Compatible 200 mg/ml + injectionBretylium tosilate 50 mg/ml + None
Compatible 200 mg/ml + injectionCaffeine 10 mg/ml + None
Compatible 200 mg/ml + injectionCalcium chloride 78 mg/ml + None
Compatible 200 mg/ml + injectionCalcium gluconate 100 mg/ml + None
Compatible 200 mg/ml + injectionCaspofungin acetate + None
Incompatible 200 mg/ml + injectionCefazolin sodium + None
Compatible 200 mg/ml + injectionCefotaxime sodium + None
Compatible 200 mg/ml + injectionCefoxitin sodium + None
Compatible 200 mg/ml + injectionCeftazidime + None
Compatible 200 mg/ml + injectionCeftriaxone disodium + None
Incompatible 200 mg/ml + injectionCefuroxime sodium + None
Incompatible 200 mg/ml + injectionChlorpromazine hydrochloride 25 mg/ml + None
Incompatible 200 mg/ml + injectionCiclosporin 50 mg/ml + None
Compatible 200 mg/ml + injectionCiprofloxacin lactate 2 mg/ml + None
Compatible 200 mg/ml + injectionClindamycin phosphate 150 mg/ml + None
Incompatible 200 mg/ml + injectionCloxacillin sodium + None
Compatible 200 mg/ml + injectionCo-trimoxazole 16/80 mg/ml + None
Incompatible 200 mg/ml + injectionDexamethasone sodium phosphate 4 mg/ml + None
Compatible 200 mg/ml + injectionDiazepam 5 mg/ml + None
Compatible 200 mg/ml + injectionDigoxin 50 µg/ml + None
Compatible 200 mg/ml + injectionDiphenhydramine hydrochloride 50 mg/ml + None
Incompatible 200 mg/ml + injectionDobutamine hydrochloride 12.5 mg/ml + None
Compatible 200 mg/ml + injectionDopamine hydrochloride 3.2 mg/ml + None
Compatible 200 mg/ml + injectionDroperidol 2.5 mg/ml + None
Compatible 200 mg/ml + injectionEnalaprilate 1.25 mg/ml + None
Incompatible 200 mg/ml + injectionEpinephrine hydrochloride 1000 µg/ml + None
Incompatible 200 mg/ml + injectionErythromycin lactobionate + None
Incompatible 200 mg/ml + injectionFentanyl citrate 50 µg/ml + None
Compatible 200 mg/ml + injectionFluconazole 2 mg/ml + None
Compatible 200 mg/ml + injectionFurosemide 10 mg/ml + None
Compatible 200 mg/ml + injectionGentamicin sulfate 40 mg/ml + None
Compatible 200 mg/ml + injectionHeparin sodium 1000 UI/ml + None
Compatible 200 mg/ml + injectionHydralazine hydrochloride + None
Compatible 200 mg/ml + injectionHydrocortisone sodium succinate + None
Incompatible 200 mg/ml + injectionInsulin 100 UI/ml + None
Compatible 200 mg/ml + injectionLabetalol hydrochloride 5 mg/ml + None
Compatible 200 mg/ml + injectionLidocaine hydrochloride 1 mg/ml + None
Compatible 200 mg/ml + injectionMannitol 250 mg/ml + None
Incompatible 200 mg/ml + injectionMetronidazole 5 mg/ml + None
Compatible 200 mg/ml + injectionMidazolam hydrochloride 5 mg/ml + None
Compatible 200 mg/ml + injectionMilrinone lactate 1 mg/ml + None
Compatible 200 mg/ml + injectionNitroglycerin 5 mg/ml + None
Compatible 200 mg/ml + injectionNorepinephrine bitartrate 1 mg/ml + None
Compatible 200 mg/ml + injectionPiperacillin sodium + None
Compatible 200 mg/ml + injectionPiperacillin sodium / tazobactam + None
Compatible 200 mg/ml + injectionPotassium chloride 200 mEq/l + None
Compatible 200 mg/ml + injectionPropranolol hydrochloride 1 mg/ml + None
Compatible 200 mg/ml + injectionRanitidine hydrochloride 25 mg/ml + None
Compatible 200 mg/ml + injectionRocuronium bromide 10 mg/ml + None
Compatible 200 mg/ml + injectionSodium bicarbonate 84 mg/ml + None
Compatible 200 mg/ml + injectionTicarcillin / clavulanic acid 31 mg/ml + None
Compatible 200 mg/ml + injectionVerapamil hydrochloride 2.5 mg/ml + None
injectionNitroglycerin Vasodilator
Compatible 5 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 1 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionPiperacillin sodium Antibiotic
Compatible + injectionN-acetylcysteine 200 mg/ml + None
injectionPiperacillin sodium / tazobactam Antibiotic
Compatible + injectionN-acetylcysteine 200 mg/ml + None
injectionPotassium chloride Electrolyte
Compatible 200 mEq/l + injectionN-acetylcysteine 200 mg/ml + None
injectionPropranolol hydrochloride Beta-blocker
Compatible 1 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 25 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionRocuronium bromide Curarimimetic
Compatible 10 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionTicarcillin / clavulanic acid Antibiotic
Compatible 31 mg/ml + injectionN-acetylcysteine 200 mg/ml + None
injectionVerapamil hydrochloride Anti-arrhythmic
Compatible 2.5 mg/ml + injectionN-acetylcysteine 200 mg/ml + None

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