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References   References 81  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/51/5/672
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Martinez JF.
Title : Compatibility of piperacillin sodium plus tazobactam with selected drugs during simulated Y-site injection.
Reference : Am J Hosp Pharm ; 51: 672-678. 1994
Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only
List of drugs
injectionAciclovir sodium Antiviral
Incompatible 7 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionAminophylline Various
Compatible 2.5 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionAmphotericin B Antifungal
Incompatible 0.6 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionAztreonam Antibiotic
Compatible 40 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionBleomycin sulfate Anticancer drug
Compatible 1 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionBumetanide Diuretic
Compatible 0.04 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionBuprenorphine hydrochloride Analgesic
Compatible 0.04 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionButorphanol tartrate Analgesic
Compatible 0.04 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionCalcium gluconate Electrolyte
Compatible 40 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionCarboplatin Anticancer drug
Compatible 5 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionCarmustine Anticancer drug
Compatible 1.5 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionChlorpromazine hydrochloride Anxiolytic
Incompatible 2 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionCisplatin Anticancer drug
Incompatible 1 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionCo-trimoxazole Antibiotic
Compatible 0.8/4 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionCyclophosphamide Anticancer drug
Compatible 10 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionCytarabine Anticancer drug
Compatible 50 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionDacarbazine Anticancer drug
Incompatible 4 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionDaunorubicin hydrochloride Anticancer drug
Incompatible 1 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionDobutamine hydrochloride Cardiotonic
Incompatible 4 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionDopamine hydrochloride Cardiotonic
Compatible 3.2 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionDoxorubicin hydrochloride Anticancer drug
Incompatible 2 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionDoxycycline hyclate Antibiotic
Incompatible 1 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionDroperidol Neuroleptic
Incompatible 0.4 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionEnalaprilate Antihypertensive
Compatible 0.1 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionEtoposide Anticancer drug
Compatible 0.4 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionFamotidine Antihistamine (H2)
Incompatible 2 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionFloxuridine Anticancer drug
Compatible 3 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionFluconazole Antifungal
Compatible 2 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionFludarabine phosphate Anticancer drug
Compatible 1 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionFluorouracil Anticancer drug
Compatible 16 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionFolinate calcium Cytoprotective
Compatible 2 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionFurosemide Diuretic
Compatible 3 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionGallium nitrate Calcium-lowering agent
Compatible 0.4 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionGanciclovir sodium Antiviral
Incompatible 20 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionHaloperidol lactate Neuroleptic
Incompatible 0.2 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionHeparin sodium Anticoagulant
Compatible 100 UI/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionHydromorphone hydrochloride Analgesic
Compatible 0.5 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionHydroxyzine dihydrochloride Anxiolytic
Incompatible 4 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionIdarubicin hydrochloride Anticancer drug
Incompatible 0.5 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionIfosfamide Anticancer drug
Compatible 25 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionLorazepam Anxiolytic
Compatible 0.1 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionMannitol Various
Compatible 150 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionMesna Cytoprotective
Compatible 10 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionMethotrexate sodium Anticancer drug
Compatible 15 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 5 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionMinocycline hydrochloride Antibiotic
Incompatible 1 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionMitomycin Anticancer drug
Incompatible 0.5 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionMitoxantrone dihydrochloride Anticancer drug
Incompatible 0.5 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionMorphine sulfate Analgesic
Compatible 1 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionNalbuphine hydrochloride Antidote
Incompatible 10 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionOndansetron hydrochloride Antiemetic
Compatible 0.1 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionPethidine hydrochloride Analgesic
Compatible 4 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionPiperacillin sodium / tazobactam Antibiotic
Incompatible 40/5 mg/ml + injectionAciclovir sodium 7 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionAminophylline 2.5 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionAmphotericin B 0.6 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionAztreonam 40 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionBleomycin sulfate 1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionBumetanide 0.04 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionBuprenorphine hydrochloride 0.04 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionButorphanol tartrate 0.04 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionCalcium gluconate 40 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionCarboplatin 5 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionCarmustine 1.5 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionChlorpromazine hydrochloride 2 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionCimetidine hydrochloride 12 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionCisplatin 1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionClindamycin phosphate 10 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionCo-trimoxazole 0.8/4 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionCyclophosphamide 10 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionCytarabine 50 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionDacarbazine 4 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionDaunorubicin hydrochloride 1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionDexamethasone sodium phosphate 1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionDiphenhydramine hydrochloride 2 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionDobutamine hydrochloride 4 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionDopamine hydrochloride 3.2 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionDoxorubicin hydrochloride 2 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionDoxycycline hyclate 1 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionDroperidol 0.4 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionEnalaprilate 0.1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionEtoposide 0.4 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionFamotidine 2 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionFloxuridine 3 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionFluconazole 2 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionFludarabine phosphate 1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionFluorouracil 16 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionFolinate calcium 2 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionFurosemide 3 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionGallium nitrate 0.4 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionGanciclovir sodium 20 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionHaloperidol lactate 0.2 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionHeparin sodium 100 UI/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionHydrocortisone sodium succinate 1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionHydromorphone hydrochloride 0.5 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionHydroxyzine dihydrochloride 4 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionIdarubicin hydrochloride 0.5 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionIfosfamide 25 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionLorazepam 0.1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionMagnesium sulfate 100 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionMannitol 150 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionMesna 10 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionMethotrexate sodium 15 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionMethylprednisolone sodium succinate 5 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionMetoclopramide hydrochloride 5 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionMetronidazole 5 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionMinocycline hydrochloride 1 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionMitomycin 0.5 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionMitoxantrone dihydrochloride 0.5 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionMorphine sulfate 1 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionNalbuphine hydrochloride 10 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionOndansetron hydrochloride 0.1 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionPethidine hydrochloride 4 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionPotassium chloride 100 mEq/l + Glucose 5%
Incompatible 40/5 mg/ml + injectionProchlorperazine edysilate 0.5 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionPromethazine hydrochloride 2 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionRanitidine hydrochloride 2 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionSargramostim 10 µg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionSodium bicarbonate 84 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionStreptozocin 40 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionThiotepa 1 mg/ml + Glucose 5%
Incompatible 40/5 mg/ml + injectionVancomycin hydrochloride 10 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionVinblastine sulfate 0.12 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionVincristine sulfate 0.05 mg/ml + Glucose 5%
Compatible 40/5 mg/ml + injectionZidovudine 4 mg/ml + Glucose 5%
injectionPotassium chloride Electrolyte
Compatible 100 mEq/l + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionProchlorperazine edysilate Neuroleptic
Incompatible 0.5 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionPromethazine hydrochloride Antihistamine (H1)
Incompatible 2 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionSargramostim Various
Compatible 10 µg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionStreptozocin Anticancer drug
Incompatible 40 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionThiotepa Anticancer drug
Compatible 1 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionVancomycin hydrochloride Antibiotic
Incompatible 10 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionVinblastine sulfate Anticancer drug
Compatible 0.12 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionVincristine sulfate Anticancer drug
Compatible 0.05 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
injectionZidovudine Antiviral
Compatible 4 mg/ml + injectionPiperacillin sodium / tazobactam 40/5 mg/ml + Glucose 5%
  Mentions Légales