Last update :
19/11/2024
References   References 1972  
Type : Journal
Web link : http://www.tandfonline.com/doi/full/10.3109/03639045.2015.1038273#abstract

Research teams : Lille - Faculté des Sciences Pharmaceutiques et Biologiques
Authors : Feutry, F., Simon, N., Genay, S., Lannoy, D., Barthelemy, C., Decaudin, B., Labalette, P., Odou, P.
Title : Stability of 10 mg/mL cefuroxime solution for intracameral injection in commonly used polypropylene syringes and new ready-to-use cyclic olefin copolymer sterile vials using the LC–UV stability-indicating method.
Reference : Drug Dev Ind Pharm ; 42, 1: 166-174. 2016

Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
Degradation products quantified but not identified
No visual inspection

List of drugs
injectionCefuroxime sodium Antibiotic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 10 mg/ml -20°C Protect from light
365 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 10 mg/ml 25°C Protect from light
16 Hour
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 10 mg/ml 5°C Protect from light
21 Day
Stability in solutions AT-Closed vial® Sodium chloride 0,9% 10 mg/ml -20°C Protect from light
365 Day
Stability in solutions AT-Closed vial® Sodium chloride 0,9% 10 mg/ml 25°C Protect from light
16 Hour
Stability in solutions AT-Closed vial® Sodium chloride 0,9% 10 mg/ml 5°C Protect from light
21 Day

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