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Analgesic   Morphine sulfate  
injection
Ointments Oral solution
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Dimor F Brazil
Duramorph United States of America
Infumorph United States of America
Miniject Morphine Great Britain
Morphine Canada
Morphine sulfate Lavoisier France
Stability of mixtures   injection   Stability of mixtures : Morphine sulfate     
Container Solvent Concentration Compound Temperature Storage Duration of stability References
Glass NaCl 0,9% or Glucose 5% 7,5 mg/ml
injection   Morphine sulfate   
injection   Esmolol hydrochloride 5 mg/ml
15°C-30°C
8 Hour
Light 8
Glass NaCl 0,9% or Glucose 5% 2,5 & 5 mg/ml
injection   Morphine sulfate   
injection   Midazolam hydrochloride 2,5 mg/ml
20°C-25°C
14 Day
Protect from light 1492
Glass NaCl 0,9% or Glucose 5% 0,1 & 1 mg/ml
injection   Morphine sulfate   
injection   Tirofiban 50 µg/ml
20°C-25°C
4 Hour
Light 1603
Level of evidence A+
Glass Sodium chloride 0,9% 0,5 mg/ml
injection   Morphine sulfate   
injection   Granisetron hydrochloride 0,5 mg/ml
20°C-23°C
4 Hour
Protect from light 57
Level of evidence A+
Glass Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Metoclopramide hydrochloride 0,5 mg/ml
22°C
42 Day
Protect from light 1495
Level of evidence B
Glass Sodium chloride 0,9% 0,5 & 1,5 mg/ml
injection   Morphine sulfate   
injection   Tacrolimus 5 & 20 µg/ml
23°C-25°C
4 Hour
Light 814
Level of evidence A
Glass Sodium chloride 0,9% 1 & 1,5 mg/ml
injection   Morphine sulfate   
injection   Baclofen 0,2 & 0,8 mg/ml
37°C
30 Day
Not specified 1467
Level of evidence A+
Glass Sodium chloride 0,9% 7,5 mg/ml
injection   Morphine sulfate   
injection   Baclofen 1,5 mg/ml
37°C
30 Day
Not specified 1678
Level of evidence A
Glass Sodium chloride 0,9% 15 mg/ml
injection   Morphine sulfate   
injection   Baclofen 1 mg/ml
37°C
30 Day
Not specified 1678
Level of evidence A
Glass Sodium chloride 0,9% 21 mg/ml
injection   Morphine sulfate   
injection   Baclofen 0,2 mg/ml
37°C
30 Day
Not specified 1678
Level of evidence A
Glass Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Metoclopramide hydrochloride 0,5 mg/ml
4°C
189 Day
Protect from light 1495
Level of evidence B
Glass Glucose 5% 0,5 mg/ml
injection   Morphine sulfate   
injection   Labetalol hydrochloride 1 mg/ml
20°C-25°C
4 Hour
Light 199
Level of evidence A
Glass Glucose 5% 1 mg/ml
injection   Morphine sulfate   
injection   Metoclopramide hydrochloride 0,5 mg/ml
22°C
14 Day
Protect from light 1495
Level of evidence B
Glass Glucose 5% 0,5 mg/ml
injection   Morphine sulfate   
injection   Milrinone lactate 0,2 mg/ml
22°C-23°C
4 Hour
Light 813
Level of evidence A
Glass Glucose 5% 0,25 & 1 mg/ml
injection   Morphine sulfate   
injection   Midazolam hydrochloride 0,1 & 0,5 mg/ml
23°C-25°C
3 Hour
Light 86
Level of evidence C
Glass Glucose 5% 0,5 mg/ml
injection   Morphine sulfate   
injection   Fluconazole 1 mg/ml
25°C
24 Hour
Light 257
Level of evidence D
Glass Glucose 5% 1 mg/ml
injection   Morphine sulfate   
injection   Metoclopramide hydrochloride 0,5 mg/ml
4°C
35 Day
Protect from light 1495
Level of evidence B
Glass None 7,7 mg/ml
injection   Morphine sulfate   
injection   Palonosetron hydrochloride 25 µg/ml
25°C
4 Hour
Light 2196
Level of evidence A+
Glass None 50 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 2 mg/ml
injection   Bupivacaine hydrochloride 25 mg/ml
37°C
90 Day
Protect from light 1948
Level of evidence A
Glass None 50 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 2 mg/ml
injection   Bupivacaine hydrochloride 25 mg/ml
4°C
90 Day
Protect from light 1948
Level of evidence A
Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Metoclopramide hydrochloride 0,5 mg/ml
22°C
42 Day
Protect from light 1495
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Ondansetron hydrochloride 0,1 & 1 mg/ml
22°C
31 Hour
Not specified 6
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Naloxone hydrochloride 0.004 mg/ml
22°C
72 Hour
Not specified 3434
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Naloxone hydrochloride 0,0125 mg/ml
22°C
72 Hour
Not specified 3434
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Naloxone hydrochloride 0,025 mg/ml
22°C
72 Hour
Not specified 3434
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 0,1 & 0,5 mg/ml
injection   Morphine sulfate   
injection   Bupivacaine hydrochloride 0,62 & 1,25 mg/ml
23°C-25°C
72 Hour
Light 220
Polyvinyl chloride Sodium chloride 0,9% 1 & 25 mg/ml
injection   Morphine sulfate   
injection   Ketamine hydrochloride 1 & 25 mg/ml
25°C
6 Day
Not specified 2350
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Ondansetron hydrochloride 0,1 & 1 mg/ml
32°C
7 Hour
Not specified 6
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Metoclopramide hydrochloride 0,5 mg/ml
4°C
189 Day
Protect from light 1495
Level of evidence B
Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Ondansetron hydrochloride 0,1 & 1 mg/ml
4°C
31 Hour
Protect from light 6
Level of evidence A+
Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Naloxone hydrochloride 0,025 mg/ml
4°C
30 Day
Not specified 3434
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Naloxone hydrochloride 0,0125 mg/ml
4°C
30 Day
Not specified 3434
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Naloxone hydrochloride 0,004 mg/ml
4°C
30 Day
Not specified 3434
Level of evidence D
Polypropylene Water for Injection 50 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 4 mg/ml
23°C
60 Day
Light 1708
Level of evidence A+
Polypropylene Water for Injection 50 mg/ml
injection   Morphine sulfate   
injection   Bupivacaine hydrochloride 25 mg/ml
23°C
60 Day
Light 1707
Level of evidence A+
Polypropylene Water for Injection 50 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 4 mg/ml
37°C
48 Hour
Protect from light 1708
Level of evidence A+
Polypropylene Water for Injection 50 mg/ml
injection   Morphine sulfate   
injection   Bupivacaine hydrochloride 25 mg/ml
37°C
48 Hour
Protect from light 1707
Level of evidence A+
Polypropylene Water for Injection 5,9 mg/ml
injection   Morphine sulfate   
injection   Levomepromazine 0,74 mg/ml
37°C
4 Hour
Not specified 3279
Level of evidence A
Polypropylene Water for Injection 50 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 4 mg/ml
4°C
60 Day
Protect from light 1708
Level of evidence A+
Polypropylene Water for Injection 50 mg/ml
injection   Morphine sulfate   
injection   Bupivacaine hydrochloride 25 mg/ml
4°C
60 Day
Protect from light 1707
Level of evidence A+
Polypropylene Sodium chloride 0,9% 0,8 mg/ml
injection   Morphine sulfate   
injection   Alfentanil hydrochloride 55 µg/ml
2-8°C
180 Day
Protect from light 2086
Level of evidence A
Polypropylene Sodium chloride 0,9% 0,8 mg/ml
injection   Morphine sulfate   
injection   Alfentanil hydrochloride 55 µg/ml
22°C
180 Day
Protect from light 2086
Level of evidence A
Polypropylene Sodium chloride 0,9% 5 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 0,25 mg/ml
23°C
60 Day
Light 1708
Level of evidence A+
Polypropylene Sodium chloride 0,9% 5 mg/ml
injection   Morphine sulfate   
injection   Bupivacaine hydrochloride 2,5 mg/ml
23°C
60 Day
Light 1707
Level of evidence A+
Polypropylene Sodium chloride 0,9% 2 >> 10 mg/ml
injection   Morphine sulfate   
injection   Ketamine hydrochloride 2 mg/ml
23°C
91 Day
Light 2322
Level of evidence A
Polypropylene Sodium chloride 0,9% 2,67 mg/ml
injection   Morphine sulfate   
injection   Ondansetron hydrochloride 1,33 mg/ml
23°C
24 Hour
Light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 1 >> 25 mg/ml
injection   Morphine sulfate   
injection   Ketamine hydrochloride 1 >> 25 mg/ml
25°C
6 Day
Not specified 2350
Level of evidence D
Polypropylene Sodium chloride 0,9% 0,02 mg/ml
injection   Morphine sulfate   
injection   Ropivacain hydrochloride 1 & 2 mg/ml
30°C
30 Day
Protect from light 1665
Polypropylene Sodium chloride 0,9% 0,1 mg/ml
injection   Morphine sulfate   
injection   Ropivacain hydrochloride 2 mg/ml
30°C
30 Day
Protect from light 1665
Polypropylene Sodium chloride 0,9% 5 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 0,25 mg/ml
37°C
48 Hour
Protect from light 1708
Level of evidence A+
Polypropylene Sodium chloride 0,9% 5 mg/ml
injection   Morphine sulfate   
injection   Bupivacaine hydrochloride 2,5 mg/ml
37°C
48 Hour
Protect from light 1707
Level of evidence A+
Polypropylene Sodium chloride 0,9% 5 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 0,25 mg/ml
4°C
60 Day
Protect from light 1708
Level of evidence A+
Polypropylene Sodium chloride 0,9% 5 mg/ml
injection   Morphine sulfate   
injection   Bupivacaine hydrochloride 2,5 mg/ml
4°C
60 Day
Protect from light 1707
Level of evidence A+
Polypropylene Sodium chloride 0,9% 2,67 mg/ml
injection   Morphine sulfate   
injection   Ondansetron hydrochloride 1,33 mg/ml
4°C
24 Hour
Protect from light 815
Level of evidence C+
Polypropylene Sodium chloride 0,9% 2 >> 10 mg/ml
injection   Morphine sulfate   
injection   Ketamine hydrochloride 2 mg/ml
5°C
91 Day
Protect from light 2322
Level of evidence A
Polyolefine Sodium chloride 0,9% 2 mg/ml
injection   Morphine sulfate   
injection   Ropivacain hydrochloride 6 mg/ml
injection   Ziconotide acetate 0,2 µg/ml
18-24°C
14 Day
Not specified 3998
Level of evidence D
Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 0,001 mg/ml
2-8°C
5 Day
Protect from light 4730
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 0,02 mg/ml
2-8°C
5 Day
Protect from light 4730
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 10 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 0,02 mg/ml
2-8°C
5 Day
Protect from light 4730
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 3,5 mg/ml
injection   Morphine sulfate   
injection   Ropivacain hydrochloride 7.5 mg/ml
injection   Ziconotide acetate 1 µg/ml
2-8°C
3 Day
Not specified 3998
Level of evidence D
Polypropylen Syringe Sodium chloride 0,9% 0,5 >> 30 mg/ml
injection   Morphine sulfate   
injection   Ziconotide acetate 0,2 >> 3 µg/ml
2-8°C
7 Day
Not specified 4496
Level of evidence D
Polypropylen Syringe Sodium chloride 0,9% 1,76 mg/ml
injection   Morphine sulfate   
injection   Droperidol 0,2 mg/ml
20°C-25°C
14 Day
Light 1968
Level of evidence D
Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Metoclopramide hydrochloride 0,5 mg/ml
22°C
42 Day
Protect from light 1495
Level of evidence B
Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 0,02 mg/ml
23-27°C
5 Day
Protect from light 4730
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 0,001 mg/ml
23-27°C
5 Day
Protect from light 4730
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 10 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 0,02 mg/ml
23-27°C
5 Day
Protect from light 4730
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Metoclopramide hydrochloride 0,5 mg/ml
4°C
189 Day
Protect from light 1495
Level of evidence B
Synchromed® Sodium chloride 0,9% 0,5 mg/ml
injection   Morphine sulfate   
injection   Ropivacain hydrochloride 0,5 mg/ml
injection   Ziconotide acetate 0,5 µg/ml
37°C
14 Day
Protect from light 4669
Level of evidence B+
Synchromed® Sodium chloride 0,9% 6 mg/ml
injection   Morphine sulfate   
injection   Ropivacain hydrochloride 8,5 mg/ml
injection   Ziconotide acetate 0,5 µg/ml
37°C
21 Day
Protect from light 4669
Level of evidence B+
Synchromed® Sodium chloride 0,9% 10 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 0,02 mg/ml
37°C
28 Day
Protect from light 4730
Level of evidence A+
Synchromed® Sodium chloride 0,9% 1 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 0,001 mg/ml
37°C
28 Day
Protect from light 4730
Level of evidence A+
Synchromed® Sodium chloride 0,9% 0,5 mg/ml
injection   Morphine sulfate   
injection   Ropivacain hydrochloride 8,5 mg/ml
injection   Ziconotide acetate 0,5 µg/ml
37°C
60 Day
Protect from light 4669
Level of evidence B+
Synchromed® Sodium chloride 0,9% 0,5 mg/ml
injection   Morphine sulfate   
injection   Ropivacain hydrochloride 0,5 mg/ml
injection   Ziconotide acetate 2 µg/ml
37°C
60 Day
Protect from light 4669
Level of evidence B+
Not specified Sodium chloride 0,9% 0,05 mg/ml
injection   Morphine sulfate   
injection   Bupivacaine hydrochloride 1 mg/ml
23°C
28 Day
Light 1276
Level of evidence D
Not specified Sodium chloride 0,9% 35 mg/ml
injection   Morphine sulfate   
injection   Ziconotide acetate 25 µg/ml
37°C
8 Day
Protect from light 2251
Level of evidence D
Not specified Sodium chloride 0,9% 20 mg/ml
injection   Morphine sulfate   
injection   Ziconotide acetate 25 µg/ml
37°C
19 Day
Protect from light 2298
Level of evidence D
Not specified Sodium chloride 0,9% 10 mg/ml
injection   Morphine sulfate   
injection   Ziconotide acetate 25 µg/ml
37°C
34 Day
Protect from light 2298
Level of evidence D
Not specified Sodium chloride 0,9% 50 mg/ml
injection   Morphine sulfate   
injection   Bupivacaine hydrochloride 24 mg/ml
injection   Clonidine hydrochloride 2 mg/ml
37°C
90 Day
Protect from light 2305
Not specified Sodium chloride 0,9% 0,05 mg/ml
injection   Morphine sulfate   
injection   Bupivacaine hydrochloride 1 mg/ml
4°C
28 Day
Protect from light 1276
Level of evidence D
Not specified Sodium chloride 0,9% 20 mg/ml
injection   Morphine sulfate   
injection   Ziconotide acetate 25 µg/ml
5°C
28 Day
Protect from light 2298
Level of evidence D
Not specified Sodium chloride 0,9% 10 mg/ml
injection   Morphine sulfate   
injection   Ziconotide acetate 25 µg/ml
5°C
60 Day
Protect from light 2298
Level of evidence D
Not specified None 20 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 0,05 mg/ml
37°C
90 Day
Not specified 1869
Level of evidence B
Not specified None 2 mg/ml
injection   Morphine sulfate   
injection   Clonidine hydrochloride 1,84 mg/ml
37°C
90 Day
Not specified 1869
Level of evidence B
  Mentions Légales