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Antihypertensive   Clonidine hydrochloride  
Injection
Capsule Oral solution Paper bag
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Catapres Australia, Great Britain, Ireland, New Zealand
Catapresan Austria, Finland, Germany, Greece, Italy, Netherlands, Spain, Sweden, Switzerland, Venezuela
Catapressan Belgium, France, Luxembourg, Morocco, Tunisia
Clonidin Brazil, Germany
Clonidina Argentina, Chile, Spain, Venezuela
Clonipres Venezuela
Haemiton Germany
Lowpres Venezuela
Paracefan Germany
Stability of mixtures   Injection   Stability of mixtures : Clonidine hydrochloride     
Container Solvent Concentration Compound Temperature Storage Duration of stability References
Glass Sodium chloride 0,9% 0,2 mg/ml
Injection   Clonidine hydrochloride   
Injection   Baclofen 1 mg/ml
37°C
70 Day
Protect from light 1601
Level of evidence C
Glass Sodium chloride 0,9% 0,25 & 0,5 mg/ml
Injection   Clonidine hydrochloride   
Injection   Baclofen 0,25 & 0,5 mg/ml
37°C
84 Day
Not specified 1928
Level of evidence D
Glass None 2 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 50 mg/ml
Injection   Bupivacaine hydrochloride 25 mg/ml
37°C
90 Day
Protect from light 1948
Level of evidence A
Glass None 2 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 50 mg/ml
Injection   Bupivacaine hydrochloride 25 mg/ml
4°C
90 Day
Protect from light 1948
Level of evidence A
Polyvinyl chloride Not specified 0,03 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine hydrochloride 6,66 mg/ml
Injection   Bupivacaine hydrochloride 3 mg/ml
25°C
90 Day
Not specified 346
Level of evidence D
Polyvinyl chloride Sodium chloride 0,9% 0,003 mg/ml
Injection   Clonidine hydrochloride   
Injection   Pethidine hydrochloride 8 mg/ml
25°C
21 Day
Light 2184
Level of evidence D
Polypropylene Water for Injection 4 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 50 mg/ml
23°C
60 Day
Light 1708
Level of evidence A+
Polypropylene Water for Injection 4 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 50 mg/ml
37°C
48 Hour
Protect from light 1708
Level of evidence A+
Polypropylene Water for Injection 4 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 50 mg/ml
4°C
60 Day
Protect from light 1708
Level of evidence A+
Polypropylene Sodium chloride 0,9% 0,25 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 5 mg/ml
23°C
60 Day
Light 1708
Level of evidence A+
Polypropylene Sodium chloride 0,9% 0,015 mg/ml
Injection   Clonidine hydrochloride   
Injection   Midazolam hydrochloride 3,6 mg/ml
Injection   Sufentanil citrate 0,03 mg/ml
25°C
7 Day
Light 3705
Level of evidence D
Polypropylene Sodium chloride 0,9% 0,015 mg/ml
Injection   Clonidine hydrochloride   
Injection   Lormetazepam 0,12 mg/ml
25°C
7 Day
Light 3705
Level of evidence D
Polypropylene Sodium chloride 0,9% 0,015 mg/ml
Injection   Clonidine hydrochloride   
Injection   Ketamine hydrochloride 25 mg/ml
25°C
7 Day
Light 3705
Level of evidence D
Polypropylene Sodium chloride 0,9% 0,015 mg/ml
Injection   Clonidine hydrochloride   
Injection   Midazolam hydrochloride 3,6 mg/ml
25°C
7 Day
Light 3705
Level of evidence D
Polypropylene Sodium chloride 0,9% 0,015 mg/ml
Injection   Clonidine hydrochloride   
Injection   Piritramide 1 mg/ml
25°C
7 Day
Light 3705
Level of evidence D
Polypropylene Sodium chloride 0,9% 0,015 mg/ml
Injection   Clonidine hydrochloride   
Injection   Piritramide 1 mg/ml
Injection   Midazolam hydrochloride 3,6 mg/ml
Injection   Ketamine hydrochloride 25 mg/ml
Injection   Lormetazepam 0,12 mg/ml
Injection   Sufentanil citrate 0,03 mg/ml
25°C
8 Hour
Light 3705
Level of evidence D
Polypropylene Sodium chloride 0,9% 0,005 mg/ml
Injection   Clonidine hydrochloride   
Injection   Propofol 6,7 mg/ml
Injection   Sufentanil citrate 0,01 mg/ml
25°C
24 Hour
Light 4011
Level of evidence C+
Polypropylene Sodium chloride 0,9% 0,0075 mg/ml
Injection   Clonidine hydrochloride   
Injection   Propofol 10 mg/ml
25°C
24 Hour
Light 4011
Level of evidence C+
Polypropylene Sodium chloride 0,9% 0,0136 mg/ml
Injection   Clonidine hydrochloride   
Injection   Propofol 1,8 mg/ml
25°C
24 Hour
Light 4011
Level of evidence C+
Polypropylene Sodium chloride 0,9% 0,00136 mg/ml
Injection   Clonidine hydrochloride   
Injection   Propofol 18 mg/ml
25°C
24 Hour
Light 4011
Level of evidence C+
Polypropylene Sodium chloride 0,9% 0.05 & 0.005 mg/ml
Injection   Clonidine hydrochloride   
Injection   Ropivacain hydrochloride 1 & 2 mg/ml
30°C
30 Day
Protect from light 1665
Polypropylene Sodium chloride 0,9% 0.005 mg/ml
Injection   Clonidine hydrochloride   
Injection   Ropivacain hydrochloride 2 mg/ml
30°C
30 Day
Protect from light 1665
Polypropylene Sodium chloride 0,9% 0,25 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 5 mg/ml
37°C
48 Hour
Protect from light 1708
Level of evidence A+
Polypropylene Sodium chloride 0,9% 0,25 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 5 mg/ml
4°C
60 Day
Protect from light 1708
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 0,001 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 1 mg/ml
2-8°C
5 Day
Protect from light 4730
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 0,02 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 1 mg/ml
2-8°C
5 Day
Protect from light 4730
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 0,02 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 10 mg/ml
2-8°C
5 Day
Protect from light 4730
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 0,003 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine hydrochloride 0,417 mg/ml
2-8°C
30 Day
Not specified 4643
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 0,032 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine hydrochloride 4,3 mg/ml
2-8°C
30 Day
Not specified 4643
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 0,02 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 1 mg/ml
23-27°C
5 Day
Protect from light 4730
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 0,001 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 1 mg/ml
23-27°C
5 Day
Protect from light 4730
Level of evidence A+
Polypropylen Syringe Sodium chloride 0,9% 0,02 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 10 mg/ml
23-27°C
5 Day
Protect from light 4730
Level of evidence A+
Synchromed® Sodium chloride 0,9% 0,02 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 10 mg/ml
37°C
28 Day
Protect from light 4730
Level of evidence A+
Synchromed® Sodium chloride 0,9% 0,001 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 1 mg/ml
37°C
28 Day
Protect from light 4730
Level of evidence A+
Not specified Sodium chloride 0,9% 0,0084 mg/ml
Injection   Clonidine hydrochloride   
Injection   Levobupivacaine hydrochloride ? mg/ml
20-22 °C
40 Hour
Not specified 3507
Manufacturer's stability data
Not specified Sodium chloride 0,9% 2 mg/ml
Injection   Clonidine hydrochloride   
Injection   Ziconotide acetate 25 µg/ml
37°C
60 Day
Protect from light 2248
Level of evidence D
Not specified Sodium chloride 0,9% 2 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 50 mg/ml
Injection   Bupivacaine hydrochloride 24 mg/ml
37°C
90 Day
Protect from light 2305
Not specified Sodium chloride 0,9% 2 mg/ml
Injection   Clonidine hydrochloride   
Injection   Hydromorphone hydrochloride 50 mg/ml
Injection   Bupivacaine hydrochloride 24 mg/ml
37°C
90 Day
Protect from light 2305
Not specified None 0,05 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 20 mg/ml
37°C
90 Day
Not specified 1869
Level of evidence B
Not specified None 1,84 mg/ml
Injection   Clonidine hydrochloride   
Injection   Morphine sulfate 2 mg/ml
37°C
90 Day
Not specified 1869
Level of evidence B
  Mentions Légales