Last update :
19/11/2024
Antibiotic   Penicillin G sodium  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Benapen Brazil
Bencilpenicilina Chile, Ecuador, Peru
Benpen Australia, New Zealand
Bensylpenicillin Sweden
Benzapen Iran
Benzatec Republic of South Africa
Benzatron Brazil
Benzylpenicillin Denmark, Egypt, Finland, Norway, Sweden
Benzylpenicilline Tunisia
Biconcillina Ecuador
Crystapen Canada, Great Britain, Ireland
Declin Mexico
Fortepen Saudi Arabia
Geepenil Finland
Natrium penicillin G Netherlands
Novopen Republic of South Africa
Pebencil Venezuela
Penbendox Mexico
Penibiot Spain
Penicillin Norway
Penicillina G sodica Argentina, Chile, Colombia, Ecuador, Portugal
Penilevel Spain
Sodiopen Spain
Unicillina Spain
References   injection   References : Penicillin G sodium  
Type Publication
13 Journal Stiles ML, Allen LV.
Stability of nafcillin sodium, oxacillin sodium, penicillin G potassium, penicillin G sodium and tobramycin sulfate in polyvinyl chloride drug reservoirs.
Am J Health-Syst Pharm 1997 ; 54: 1068-1070.
440 Journal Stiles ML, Tu YH, Allen LV.
Stability of cefazolin sodium, cefoxitin sodium, ceftazidime, and penicillin G sodium in portable pump reservoirs.
Am J Hosp Pharm 1989 ; 46: 1408-1412.
1057 Journal Cutie MR.
Compatibility of verapamil hydrochloride injection with commonly used additives.
Am J Hosp Pharm 1983 ; 40: 1205-1207.
1072 Journal Saltsmann CL, Tom CM, Mitchell A, Fan JH, Gailey RA.
Compatibility of levofloxacin with 34 medications during simulated Y-site administration.
Am J Health-Syst Pharm 1999 ; 56: 1458-1459.
1241 Journal Rayani S, Jamali F.
The stability of penicillin G sodium in 5% dextrose in water minibags after freezing.
Can J Hosp Pharm 1985 ; 38: 162-163.
1263 Journal Allwood MC, Brown PW.
The effect of buffering on the stability of reconstituted benzylpenicillin injection.
Int J Pharm Pract 1992 ; 1: 242-244.
1725 Journal Oliver C, Law S.
Compatibility of oxytocin, zidovudine, and penicillin G.
Can J Hosp Pharm 2001 ; 54: 112-113.
2056 Journal Vella-Brincat JWA, Begg EJ, Gallagher K, kirkpatrick CMJ, Zhang M, Frampton C, Chambers ST.
Stability of benzylpenicillin during continuous home intravenous therapy.
J Antimicrob Chemother 2004 ; 53: 675-677.
2087 Journal Ferreira E, Forest JM, Hildgen P.
Compatibility of dimenhydrinate injectable by Y administration.
Pharmactuel 2004 ; 37: 17-20.
2090 Journal Pere H, Chasse V, Forest JM, Hildgen P.
Compatibility of injectable pantoprazole in Y-site administration.
Pharmactuel 2004 ; 37: 193-196.
3012 Journal Sullivan T, Forrest J.M, Leclair G.
Compatibility of Cloxacillin Sodium with Selected Intravenous Drugs During Simulated Y-Site Administration
Hosp Pharm 2015 ; 50, 3: 214-220.
3227 Journal Simon B, Hancu G, Gy?resi A.
Application of capillary electrophoresis to the simultaneous determination and stability study of four extensively used penicillin derivatives
Braz J Pharm Sci 2014 ; 50, 3 : 521-527.
3520 Manufacturer Cidomycin - Summary of product Chracteristics.
Sanofi 2011
3529 Manufacturer Ciprofloxacin – Summary of Product Characteristics
Hospira 2013
3540 Manufacturer Heparin sodium - Summary of Product Characteristics.
Wockhardt 2010
3549 Manufacturer Amikacine B Braun - Résumé des caractéristiques du produit.
B Braun 2012
3580 Manufacturer Cytarabine Accord - Résumé des caractéristiques du produit
Accord Healthcare France 2016
3585 Manufacturer Benzylpenicillin sodium - Summary of Product Characteristics
Genus Pharmaceuticals 2008
3643 Manufacturer Gentamicin sulphate (Cidomycin®) - Summary of Product Characteristics
Sanofi 2015
3648 Journal Hossain M.A, Friciu M, Aubin S, Leclair G.
Stability of penicillin G sodium diluted with 0.9% sodium chloride injection or 5% dextrose injection and stored in polyvinyl chloride bag containers and elastomeric pump containers.
Am J Health-Syst Pharm 2014 ; 71:669-673.
3674 Manufacturer Erythromycin lactobionate - Summary of Product Characteristics
PanPharma 2016
3702 Journal McDougall D.A.J, McWhinney.
Stability of buffered benzylpenicillin solutions for outpatient parenteral antimicrobial therapy.
J Pharm Pract and Res 2014 ; 44, 1: 26-28.
3931 Manufacturer Trimébutine (Débridat®) - Résumé des caractéristiques du produit
Pfizer Laboratoire 2016
3964 Journal Audet M.A, Forest E, Friciu M, Forest J.M, Leclair G.
Compatibilité du citrate de caféine injectable avec plusieurs autres médicaments.
Pharmactuel 2017 ; 50,1 : 27-33.
4154 Manufacturer Bleomycin sulfate- Summary of Product Characteristics
Accord Health Care 2018
4319 Journal Lessard J-J, Caron E, Schérer H, Forest J-M, Leclair G.
Compatibility of Y-site Injection of Meropenem Trihydrate With 101 Other Injectable Drugs.
Hosp Pharm 2020 ; 55, 5: 332-337.
4389 Journal Côté K, Correal F, Metras M.E, Friciu M, Forest J.M, Leclair G.
Compatibilité physique des médicaments administrés en Y aux soins intensifs, en particulier la dexmédétomidine, le lévosimendan et la kétamine.
Pharmactuel 2019 ;52,4:206-213
4590 Journal Smith E.K, McWhinney MPhil B.C.
Stability of buffered benzylpenicillin and flucloxacillin for a paediatric outpatient parenteral antibiotic therapy service.
J Pediatr Pharmacol Ther 2021 ; 51: 231-237.
4603 Journal Vallée M, Barthélémy I, Friciu M, Pelletier E, Forest J.M, Benoit F, Leclair G.
Compatibility of Lactated Ringer’s Injection With 94 Selected Intravenous Drugs During Simulated Y-site Administration.
Hosp Pharm 2021 ; 56, 4: 228-234.
4831 Journal Nezvalova-Henriksen K, Huseby Holm T, Nilsson N, Kjønniksen I, Tho I.
Frequently acquired drugs in neonatal intensive care and their physical compatibility.
Acta Paediatr 2022 ;111:2307–2314. 
4837 Journal De Silva, D.T.N Petrovski M, Strunk T, Mukadam N, Page‑Sharp N, Moore B.R, Batty K.T.
Physicochemical compatibility of caffeine citrate and caffeine base injections with parenteral medications used in neonatal intensive care settings.
Eur J Clin Pharmacol 2024 ; 80:1079–1087.

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