Last update :
19/11/2024
Respiratory stimulant   Caffeine citrate  
injection
Oral solution
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Cafcit United States of America
Cafeina 25% Bioquim Argentina
Cafeina citrato Spain
Cafeina Fada Argentina
Cafeine citrate Biomed New Zealand
Cafeine Sterop Belgium
Cafeinnova Colombia
Caffeinospire Egypt
Cafirate India
Citrate de caféine Cooper France
Peyona oral y para perfusion Spain
Peyona oral/parenteral Germany, Romania, Turkey
Compatibility   injection   Compatibility : Caffeine citrate              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Compatible
injection Caffeine citrate 20 mg/ml
injection Amoxicillin sodium 100 mg/ml
Water for Injection 4837
Compatible
injection Caffeine citrate 25 mg/ml
injection Blinatumomab 0.125 & 0.375 µg/ml
Sodium chloride 0,9% 3976
Compatible
injection Caffeine citrate 10 mg/ml
Ringer’s lactate solution 4603
Immediate precipitation Incompatible
injection Caffeine citrate 20 mg/ml
injection Aciclovir sodium 5 mg/ml
4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Alprostadil 20 µg/ml
Sodium chloride 0,9% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Amphotericin B 0,1 mg/ml
Glucose 5% 4837
Immediate turbidity Incompatible
injection Caffeine citrate 20 mg/ml
injection Amphotericin B liposomale 2 mg/ml
4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Ampicillin sodium 100 mg/ml
Water for Injection 4837
Unspecified incompatibility Incompatible
injection Caffeine citrate
injection Calcium gluconate
3644
Compatible
injection Caffeine citrate 20 mg/ml
injection Calcium gluconate 100 mg/ml
4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Cefotaxime sodium 100 mg/ml
Water for Injection 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Ciprofloxacin lactate 2 mg/ml
4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Clonidine hydrochloride 0,002 mg/ml
Sodium chloride 0,9% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Cloxacillin sodium 100 mg/ml
Water for Injection 4837
Compatible
injection Caffeine citrate 10 mg/ml
injection Dexmedetomidine 100 µg/ml
4389
Compatible
injection Caffeine citrate 20 mg/ml
injection Dexmedetomidine 1 µg/ml
Sodium chloride 0,9% 4837
Compatible
injection Caffeine citrate
injection Dimenhydrinate
2087
Compatible
injection Caffeine citrate 20 mg/ml
injection Dobutamine hydrochloride 7,2 mg/ml
NaCl 0,9% or Glucose 5% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Dopamine hydrochloride 7,2 mg/ml
NaCl 0,9% or Glucose 5% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Doxapram hydrochloride 2 mg/ml
Glucose 5% 1802
Compatible
injection Caffeine citrate 20 mg/ml
injection Epinephrine hydrochloride 64 µg/ml
Glucose 5% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Fentanyl citrate 50 µg/ml
4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Flucloxacillin sodium 50 mg/ml
Glucose 5% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Fluconazole 2 mg/ml
4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Gentamicin sulfate 10 mg/ml
Sodium chloride 0,9% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Heparin sodium 100 UI/ml
Sodium chloride 0,9% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Hydrocortisone sodium succinate 1 mg/ml
Sodium chloride 0,9% 4837
Immediate precipitation Incompatible
injection Caffeine citrate 20 mg/ml
injection Hydrocortisone sodium succinate 10 mg/ml
Sodium chloride 0,9% 4837
Immediate turbidity Incompatible
injection Caffeine citrate 20 mg/ml
injection Ibuprofen lysinate 10 mg/ml
Water for Injection 4419
Immediate turbidity Incompatible
injection Caffeine citrate 20 mg/ml
injection Ibuprofen lysinate 4 mg/ml
Sodium chloride 0,9% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Indomethacin sodium trihydrate 0,2 mg/ml
Sodium chloride 0,9% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Insulin 0,2 UI/ml
Sodium chloride 0,9% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Levetiracetam 5 mg/ml
Sodium chloride 0,9% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Linezolid 2 mg/ml
4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Meropenem 50 mg/ml
Sodium chloride 0,9% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Meropenem 50 mg/ml
Water for Injection 4319
Compatible
injection Caffeine citrate 20 mg/ml
injection Metronidazole 5 mg/ml
4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Midazolam hydrochloride 1 mg/ml
4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Milrinone lactate 0,4 mg/ml
Glucose 5% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Morphine hydrochloride 0,2 mg/ml
Glucose 5% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Morphine sulfate 0,2 mg/ml
Glucose 5% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Norepinephrine bitartrate 0,064 mg/ml
Glucose 5% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Paracetamol 10 mg/ml
4742
Compatible
injection Caffeine citrate 20 mg/ml
injection Paracetamol 10 mg/ml
4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Penicillin G sodium 0.17 MUI/ml
Water for Injection 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Pentoxifyllin 5 mg/ml
Sodium chloride 0,9% 4543
Compatible
injection Caffeine citrate 20 mg/ml
injection Phenobarbital sodium 20 mg/ml
Water for Injection 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Piperacillin sodium / tazobactam 200 mg/ml
Water for Injection 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Rifampicin 6 mg/ml
Sodium chloride 0,9% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Sodium bicarbonate
Parenteral nutrition (binary mixture) 3379
Compatible
injection Caffeine citrate 20 mg/ml
injection Sodium bicarbonate 42 mg/ml
Glucose 5% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Vancomycin hydrochloride 10 mg/ml
Glucose 5% 4837
Compatible
injection Caffeine citrate 20 mg/ml
injection Vecuronium bromide 1 mg/ml
Water for Injection 4837

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