Last update :
19/11/2024
Immunosuppressant   Tacrolimus  
injection
Eye-drops Oral solution
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Prograf Australia, Austria, Canada, Chile, Colombia, Denmark, Finland, France, Germany, Great Britain, Greece, Hungary, Iran, Ireland, Italy, Japan, Malaysia, New Zealand, Norway, Poland, Portugal, Romania, Spain, Sweden, Switzerland, United States of America
Prograft Belgium, Luxembourg, Netherlands
Compatibility   injection   Compatibility : Tacrolimus              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Unspecified incompatibility Incompatible
injection Tacrolimus
injection Aciclovir sodium
3626
Compatible
injection Tacrolimus 1000 µg/ml
injection Aciclovir sodium 10 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Aminophylline 2 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Amphotericin B 5 mg/ml
Water for Injection 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Ampicillin sodium 20 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 20 µg/ml
injection Anidulafungin 0.5 mg/ml
Glucose 5% 1982
Compatible
injection Tacrolimus 100 µg/ml
Parenteral nutrition (binary mixture) 907
Compatible
injection Tacrolimus 1000 µg/ml
injection Ampicillin sodium - sulbactam sodium 50 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Benztropine mesylate 1 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
Parenteral nutrition (with lipids) 1415
Compatible
injection Tacrolimus 1000 µg/ml
injection Calcium gluconate 100 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 20 µg/ml
injection Caspofungin acetate 0,7 mg/ml
Sodium chloride 0,9% 2247
Compatible
injection Tacrolimus 1000 µg/ml
injection Cefazolin sodium 40 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Ceftazidime 20 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 5 & 20 µg/ml
injection Ceftazidime 20 & 100 mg/ml
Glucose 5% 814
Compatible
injection Tacrolimus 0.02 µg/ml
injection Ceftolozane / tazobactam 10/5 mg/ml
NaCl 0,9% or Glucose 5% 3828
Compatible
injection Tacrolimus 1000 µg/ml
injection Ceftriaxone disodium 40 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 100 µg/ml
Parenteral nutrition (with lipids) 3948
Compatible
injection Tacrolimus 1000 µg/ml
injection Cefuroxime sodium 30 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Chloramphenicol sodium succinate 20 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Cimetidine hydrochloride 150 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 10 µg/ml
injection Cimetidine hydrochloride 0,6 mg/ml
Sodium chloride 0,9% 207
Compatible
injection Tacrolimus 1000 µg/ml
injection Ciprofloxacin lactate 1 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Clindamycin phosphate 12 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Co-trimoxazole 16/8 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Dexamethasone sodium phosphate 4 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Digoxin 250 µg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Dopamine hydrochloride 1,6 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Doxycycline hyclate 5 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Erythromycin lactobionate 20 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Esmolol hydrochloride 10 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
Parenteral nutrition (binary mixture) 301
Compatible
injection Tacrolimus 20 µg/ml
injection Doripenem 5 mg/ml
NaCl 0,9% or Glucose 5% 2262
Compatible
injection Tacrolimus 100 µg/ml
Parenteral nutrition (binary mixture) 3948
Compatible
injection Tacrolimus 1000 µg/ml
injection Diphenhydramine hydrochloride 1 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Dobutamine hydrochloride 1 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 5 & 20 µg/ml
injection Fluconazole 0,5 & 1,5 mg/ml
Sodium chloride 0,9% 1421
Compatible
injection Tacrolimus 1000 µg/ml
injection Fluconazole 2 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Folinate calcium 10 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Furosemide 10 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Ganciclovir sodium 50 mg/ml
Sodium chloride 0,9% 479
Unspecified incompatibility Incompatible
injection Tacrolimus
injection Ganciclovir sodium
3626
Compatible
injection Tacrolimus 1000 µg/ml
injection Gentamicin sulfate 4 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Haloperidol lactate 2,5 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Heparin sodium 10 UI/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Hydrocortisone sodium succinate 50 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 5 & 20 µg/ml
injection Hydromorphone hydrochloride 0,1 & 1 mg/ml
Glucose 5% 814
Compatible
injection Tacrolimus 1000 µg/ml
injection Imipenem - cilastatin sodium 10 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Insulin 0,1 UI/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 20 µg/ml
injection Isavuconazonium sulfate 1.5 mg/ml
NaCl 0,9% or Glucose 5% 3829
Compatible
injection Tacrolimus 1000 µg/ml
injection Isoprenaline hydrochloride 0,04 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Lorazepam 1 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Methylprednisolone sodium succinate 0,8 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Metoclopramide hydrochloride 0,2 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Metronidazole 5 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 20 µg/ml
injection Micafungin 1.5 mg/ml
Sodium chloride 0,9% 2108
Compatible
injection Tacrolimus 5 & 20 µg/ml
injection Morphine sulfate 0,5 & 1,5 mg/ml
Sodium chloride 0,9% 814
Compatible
injection Tacrolimus 20 µg/ml
injection Mycophenolate mofetil 5,9 mg/ml
Glucose 5% 2192
Compatible
injection Tacrolimus 1000 µg/ml
injection Nitroglycerin 0,1 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Nitroprusside sodium 0,004 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Oxacillin sodium 40 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Penicillin G potassium 0,1 MUI/ml
Sodium chloride 0,9% 479
Turbidity in 24 hours Incompatible
injection Tacrolimus 1000 µg/ml
injection Phenytoin sodium 5 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Piperacillin sodium 80 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 3 µg/ml
injection Posaconazole 1,2 mg/ml
Sodium chloride 0,9% 4521
Compatible
injection Tacrolimus 30 µg/ml
injection Posaconazole 1,2 mg/ml
Sodium chloride 0,9% 4521
Compatible
injection Tacrolimus 1000 µg/ml
injection Potassium chloride 2000 mEq/l
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Propranolol hydrochloride 1 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Ranitidine hydrochloride 25 mg/ml
Sodium chloride 0,9% 479
Unspecified incompatibility Incompatible
injection Tacrolimus
injection Sodium bicarbonate
3626
Compatible
injection Tacrolimus 1000 µg/ml
injection Sodium bicarbonate 84 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 20 µg/ml
injection Tedizolid phosphate 0.8 mg/ml
Sodium chloride 0,9% 3827
Unspecified incompatibility Incompatible
injection Tacrolimus
NaHCO3 3626
Compatible
injection Tacrolimus 1000 µg/ml
injection Tobramycin sulfate 40 mg/ml
Sodium chloride 0,9% 479
Compatible
injection Tacrolimus 1000 µg/ml
injection Vancomycin hydrochloride 5 mg/ml
Sodium chloride 0,9% 479

  Mentions Légales