Last update :
28/04/2024
Analgesic   Tramadol hydrochloride  
Injection
Oral solution
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Acugesic Malaysia
Adolonta Spain
Amadol Egypt
Analgon Peru
Anangor Brazil
Autrestol Mexico
Contramal Belgium, France, Hungary, Italy, Turkey
Dalarest Mexico
Dolotramine Switzerland
Dolzam Belgium
Eufindol Chile
Fortradol Italy
Fraxidol Italy
Lafedol Argentina
Liochta Mexico
Lumidol Croatia
Mabron Thailand
Megadol Chile, Mexico
Nobligan Denmark, Mexico, Sweden
Paxilfar Portugal
Poltram Poland
Prontalgin Italy
Sylador Brazil
Tadol Slovenia
Topalgic France
Trabilin Saudi Arabia
Tradolan Austria, Denmark, Sweden
Tradonal Belgium, Thailand
Tramabene Austria
Tramadoc Germany
Tramadolor Austria
Tramadura Germany
Tramagetic Netherlands
Tramal Austria, Brazil, Croatia, Finland, Germany, Netherlands, Poland, Portugal, Republic of South Africa, Slovenia, Switzerland, Thailand
Tramastad Austria
Tramundin Germany
Zamadol Great Britain
Zamudol France
Zydol Great Britain
Compatibility   Injection   Compatibility : Tramadol hydrochloride              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Precipitation after 1 hour Incompatible
Injection Tramadol hydrochloride 0,4 mg/ml
Injection Aciclovir sodium 5 mg/ml
Sodium chloride 0,9% 2002
Compatible
Injection Tramadol hydrochloride 1 mg/ml
Injection Alizapride hydrochloride 0,5 mg/ml
Glucose 5% 3115
Compatible
Injection Tramadol hydrochloride 0,4 mg/ml
Injection Ampicillin sodium - sulbactam sodium 10/20 mg/ml
Sodium chloride 0,9% 2002
Precipitation after 2 hours Incompatible
Injection Tramadol hydrochloride 0,4 mg/ml
Injection Clindamycin phosphate 6 mg/ml
Sodium chloride 0,9% 2002
Compatible
Injection Tramadol hydrochloride 8.33>>33.33 mg/ml
Injection Dexamethasone sodium phosphate 0.33>>3.33 mg/ml
Sodium chloride 0,9% 2211
Compatible
Injection Tramadol hydrochloride 11.18 & 33.3 mg/ml
Injection Dexamethasone sodium phosphate 0.44 & 1.33 mg/ml
Sodium chloride 0,9% 1971
Immediate precipitation Incompatible
Injection Tramadol hydrochloride
Injection Diazepam
3521
Immediate precipitation Incompatible
Injection Tramadol hydrochloride
Injection Diclofenac
3521
Compatible
Injection Tramadol hydrochloride 1 mg/ml
Injection Droperidol 0,025 mg/ml
Glucose 5% 2814
Compatible
Injection Tramadol hydrochloride 10 mg/ml
Injection Granisetron hydrochloride 0.06 mg/ml
Sodium chloride 0,9% 4116
Compatible
Injection Tramadol hydrochloride 11.18 & 33.3 mg/ml
Injection Haloperidol lactate 0.21 & 0.62 mg/ml
Sodium chloride 0,9% 1971
Compatible
Injection Tramadol hydrochloride 8.33 >> 33.33 mg/ml
Injection Haloperidol lactate 0.208 >> 0.625 mg/ml
Sodium chloride 0,9% 2024
Immediate precipitation Incompatible
Injection Tramadol hydrochloride
Injection Indomethacin sodium trihydrate
3521
Compatible
Injection Tramadol hydrochloride 5 mg/ml
Injection Ketamine hydrochloride 0.5 >> 2 mg/ml
Sodium chloride 0,9% 365
Compatible
Injection Tramadol hydrochloride 20 mg/ml
Injection Ketorolac tromethamine 2 mg/ml
Sodium chloride 0,9% 3159
Compatible
Injection Tramadol hydrochloride 33.3 mg/ml
Injection Ketorolac tromethamine 10 mg/ml
None 3159
Compatible
Injection Tramadol hydrochloride 0.4 mg/ml
Injection Lornoxicam 0.4 mg/ml
Sodium chloride 0,9% 4034
Compatible
Injection Tramadol hydrochloride 0,4 mg/ml
Injection Mannitol 20 mg/ml
None 2002
Compatible
Injection Tramadol hydrochloride 1 mg/ml
Injection Metoclopramide hydrochloride 0,1 mg/ml
Glucose 5% 3082
Compatible
Injection Tramadol hydrochloride 11.18 & 33.3 mg/ml
Injection Metoclopramide hydrochloride 1.11 & 3.33 mg/ml
Sodium chloride 0,9% 1971
Immediate precipitation Incompatible
Injection Tramadol hydrochloride
Injection Midazolam hydrochloride
3521
Compatible
Injection Tramadol hydrochloride 11.18 & 33.3 mg/ml
Injection Midazolam hydrochloride 0.5 & 1.5 mg/ml
Sodium chloride 0,9% 1971
Compatible
Injection Tramadol hydrochloride 6,3 mg/ml
Injection Nefopam 0,16 mg/ml
Sodium chloride 0,9% 4698
Compatible
Injection Tramadol hydrochloride 10 mg/ml
Injection Ondansetron hydrochloride 0.08 mg/ml
Sodium chloride 0,9% 4116
Compatible
Injection Tramadol hydrochloride 0,4 mg/ml
Injection Ondansetron hydrochloride 0,016 mg/ml
Sodium chloride 0,9% 2002
Immediate precipitation Incompatible
Injection Tramadol hydrochloride
Injection Piroxicam
3521
Immediate precipitation Incompatible
Injection Tramadol hydrochloride 0,5 mg/ml
Injection Posaconazole 1,2 mg/ml
Sodium chloride 0,9% 4521
Compatible
Injection Tramadol hydrochloride 0,4 mg/ml
Injection Ranitidine hydrochloride 0,5 mg/ml
Sodium chloride 0,9% 2002
Immediate turbidity Incompatible
Injection Tramadol hydrochloride 8.33 mg/ml
Injection Rifampicin 6 mg/ml
2139
Compatible
Injection Tramadol hydrochloride 11.18 & 33.3 mg/ml
Injection Scopolamine N-butyl bromide 1.68 & 5 mg/ml
Sodium chloride 0,9% 1971
Compatible
Injection Tramadol hydrochloride 8,33>>33,3 mg/ml
Injection Scopolamine N-butyl bromide 3,33>>6,67 mg/ml
Sodium chloride 0,9% 2176
Compatible
Injection Tramadol hydrochloride 50 mg/ml
Injection Sugammadex 100 mg/ml
None 3372
Compatible
Injection Tramadol hydrochloride 50 mg/ml
Injection Temocilline 83.33 mg/ml
Water for Injection 2231
Compatible
Injection Tramadol hydrochloride 10 mg/ml
Injection Tropisetron hydrochloride 0.05 mg/ml
Sodium chloride 0,9% 4116

  Mentions Légales