Last update :
19/04/2021
References   References 4501  
Type : Journal
Web link : https://doi.org/10.1186/s12871-020-01194-5

Research teams : Randwick - The Prince of Wales Hospital, Division of Anaesthesia and intensive care
Authors : Henkel E, Vella R, Behan K, Austin D, Kruger P, Fenning A.
Title : The effect of concentration, reconstitution solution and pH on the stability of a remifentanil hydrochloride and propofol admixture for simultaneous co-infusion.
Reference : BMC Anesthesiology ;20:283. 2020

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionPropofol General anesthetic
Incompatible 9.5 mg/ml + InjectionRemifentanil hydrochloride 10 >> 50 µg/ml + NaHCO3
InjectionRemifentanil hydrochloride Analgesic
Factors which affect stability Solvent NaHCO3 Induces Degradation
Factors which affect stability PH PH >7 Induces Degradation
Stability in solutions Glass Water for Injection 10 >> 50 µg/ml 20-22°C Not specified
24 Hour
Stability in solutions Glass Sodium chloride 0,9% 10 >> 50 µg/ml 20-22°C Not specified
24 Hour
Incompatible + NaHCO3
Incompatible 10 >> 50 µg/ml + InjectionPropofol 9.5 mg/ml + NaHCO3

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