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References   References 1506  
Type : Journal
Web link : http://dx.doi.org/10.1136/ejhpharm-2014-000539
Research teams : Barcelona - Hopital Clinic of Barcelona
Authors : Lopez-Cabezas C, Guerrero L, Molas G, Anglada H, Soy D.
Title : Physicochemical compatibility of high concentration drugs usually Y-site administered in intensive care units.
Reference : EJHP ;22:107-112. 2015
Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
injectionClonidine hydrochloride Antihypertensive
Compatible 0.0075 mg/ml + injectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.0075 mg/ml + injectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.0075 mg/ml + injectionEsomeprazole sodium 0.32 mg/ml + Sodium chloride 0,9%
Compatible 0.0075 mg/ml + injectionFurosemide 2 mg/ml + Sodium chloride 0,9%
Compatible 0.0075 mg/ml + injectionHeparin sodium 50 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 0.0075 mg/ml + injectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 0.0075 mg/ml + injectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.0075 mg/ml + injectionMorphine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.0075 mg/ml + injectionPantoprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
injectionDobutamine hydrochloride Cardiotonic
Compatible 8 mg/ml + injectionClonidine hydrochloride 0.0075 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + injectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 8 mg/ml + injectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + injectionFentanyl citrate 30 µg/ml + NaCl 0,9% or Glucose 5%
Incompatible 8 mg/ml + injectionFurosemide 2 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionFurosemide 2 mg/ml + Glucose 5%
Compatible 8 mg/ml + injectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + injectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + injectionMidazolam hydrochloride 4 mg/ml + Glucose 5%
Incompatible 8 mg/ml + injectionMidazolam hydrochloride 4 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + injectionMorphine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + injectionNorepinephrine bitartrate 0.32 mg/ml + NaCl 0,9% or Glucose 5%
injectionDopamine hydrochloride Cardiotonic
Compatible 8 mg/ml + injectionClonidine hydrochloride 0.0075 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + injectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 8 mg/ml + injectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + injectionFentanyl citrate 30 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + injectionFurosemide 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + injectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + injectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + injectionMidazolam hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + injectionMorphine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 8 mg/ml + injectionNorepinephrine bitartrate 0.32 mg/ml + NaCl 0,9% or Glucose 5%
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 40 µg/ml + injectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
injectionEsomeprazole sodium Proton pump inhibitor
Compatible 0.32 mg/ml + injectionClonidine hydrochloride 0.0075 mg/ml + Sodium chloride 0,9%
Incompatible 0.32 mg/ml + injectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 0.32 mg/ml + injectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + injectionEpinephrine hydrochloride 40 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + injectionFentanyl citrate 30 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + injectionFlumazenil 0.04 mg/ml + Sodium chloride 0,9%
Compatible 0.32 mg/ml + injectionFurosemide 2 mg/ml + Sodium chloride 0,9%
Compatible 0.32 mg/ml + injectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + injectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 0.32 mg/ml + injectionMidazolam hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + injectionMorphine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionFentanyl citrate Analgesic
Compatible 30 µg/ml + injectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 30 µg/ml + injectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 30 µg/ml + injectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 30 µg/ml + injectionNorepinephrine bitartrate 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 30 µg/ml + injectionPantoprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
injectionFlumazenil Antidote
Compatible 0.04 mg/ml + injectionEsomeprazole sodium 0.32 mg/ml + Sodium chloride 0,9%
injectionFurosemide Diuretic
Compatible 2 mg/ml + injectionClonidine hydrochloride 0.0075 mg/ml + Sodium chloride 0,9%
Incompatible 2 mg/ml + injectionDobutamine hydrochloride 8 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionDobutamine hydrochloride 8 mg/ml + Glucose 5%
Compatible 2 mg/ml + injectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 2 mg/ml + injectionEsomeprazole sodium 0.32 mg/ml + Sodium chloride 0,9%
Compatible 2 mg/ml + injectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
injectionHeparin sodium Anticoagulant
Compatible 50 UI/ml + injectionClonidine hydrochloride 0.0075 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 UI/ml + injectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
injectionInsulin Glucose-lowering
Compatible 1 UI/ml + injectionClonidine hydrochloride 0.0075 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionMidazolam hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 UI/ml + injectionNorepinephrine bitartrate 0.32 mg/ml + NaCl 0,9% or Glucose 5%
injectionMethadone hydrochloride Analgesic
Compatible 0.2 mg/ml + injectionClonidine hydrochloride 0.0075 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + injectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + injectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + injectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + injectionFurosemide 2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + injectionHeparin sodium 50 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + injectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + injectionMidazolam hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + injectionNorepinephrine bitartrate 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.2 mg/ml + injectionPantoprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
injectionMidazolam hydrochloride Anxiolytic
Compatible 4 mg/ml + injectionDobutamine hydrochloride 8 mg/ml + Glucose 5%
Incompatible 4 mg/ml + injectionDobutamine hydrochloride 8 mg/ml + Sodium chloride 0,9%
Compatible 4 mg/ml + injectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 4 mg/ml + injectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 4 mg/ml + injectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 4 mg/ml + injectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 4 mg/ml + injectionNorepinephrine bitartrate 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 4 mg/ml + injectionRemifentanil hydrochloride 20 µg/ml + NaCl 0,9% or Glucose 5%
injectionMorphine hydrochloride Analgesic
Compatible 1 mg/ml + injectionClonidine hydrochloride 0.0075 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionEsomeprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 1 mg/ml + injectionNorepinephrine bitartrate 0.32 mg/ml + NaCl 0,9% or Glucose 5%
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 0.32 mg/ml + injectionDobutamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + injectionDopamine hydrochloride 8 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + injectionFentanyl citrate 30 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + injectionInsulin 1 UI/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + injectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + injectionMidazolam hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + injectionMorphine hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
injectionPantoprazole sodium Proton pump inhibitor
Compatible 0.32 mg/ml + injectionClonidine hydrochloride 0.0075 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + injectionFentanyl citrate 30 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + injectionMethadone hydrochloride 0.2 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 0.32 mg/ml + injectionRemifentanil hydrochloride 20 µg/ml + NaCl 0,9% or Glucose 5%
injectionRemifentanil hydrochloride Analgesic
Compatible 20 µg/ml + injectionMidazolam hydrochloride 4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 20 µg/ml + injectionPantoprazole sodium 0.32 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polypropylene NaCl 0,9% or Glucose 5% 22-25°C Protect from light
injection Dopamine hydrochloride 8 mg/ml
injection Dobutamine hydrochloride 8 mg/ml
24 Hour
Polypropylene NaCl 0,9% or Glucose 5% 22-25°C Protect from light
injection Dopamine hydrochloride 8 mg/ml
injection Methadone hydrochloride 0.2 mg/ml
24 Hour
Polypropylene NaCl 0,9% or Glucose 5% 22-25°C Protect from light
injection Dobutamine hydrochloride 8 mg/ml
injection Methadone hydrochloride 0.2 mg/ml
24 Hour
Polypropylene NaCl 0,9% or Glucose 5% 22-25°C Protect from light
injection Pantoprazole sodium 0.32 mg/ml
injection Methadone hydrochloride 0.2 mg/ml
24 Hour
Polypropylene NaCl 0,9% or Glucose 5% 22-25°C Protect from light
injection Midazolam hydrochloride 4 mg/ml
injection Methadone hydrochloride 0.2 mg/ml
24 Hour
Polypropylene Sodium chloride 0,9% 22-25°C Protect from light
injection Esomeprazole sodium 0.32 mg/ml
injection Methadone hydrochloride 0.2 mg/ml
24 Hour
Polypropylene Glucose 5% 22-25°C Protect from light
injection Dobutamine hydrochloride 8 mg/ml
injection Midazolam hydrochloride 4 mg/ml
24 Hour
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