Last update :
18/07/2024
References   References 1415  
Type : Journal

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel L.A, Gilbert D.L, Martinez J.F, Baker M.B, Walter W.V, Mirtallo J.M.
Title : Compatibility of medications with 3-in-1 parenteral nutrition admixtures.
Reference : JPEN ; 23: 67-74. 1999

Level of Evidence : 
Not rated
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 
Not rated: compatibility study only

List of drugs
injectionAciclovir sodium Antiviral
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 7 mg/ml + Parenteral nutrition (with lipids)
injectionAmikacin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
injectionAminophylline Various
Compatible 2.5 mg/ml + Parenteral nutrition (with lipids)
injectionAmphotericin B Antifungal
Incompatible 0.6 mg/ml + Parenteral nutrition (with lipids)
injectionAmpicillin sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
injectionAmpicillin sodium - sulbactam sodium Antibiotic
Compatible 20/10 mg/ml + Parenteral nutrition (with lipids)
injectionAztreonam Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (with lipids)
injectionBumetanide Diuretic
Compatible 0.04 mg/ml + Parenteral nutrition (with lipids)
injectionBuprenorphine hydrochloride Analgesic
Compatible 0.04 mg/ml + Parenteral nutrition (with lipids)
injectionButorphanol tartrate Analgesic
Compatible 0.04 mg/ml + Parenteral nutrition (with lipids)
injectionCalcium gluconate Electrolyte
Compatible 40 mg/ml + Parenteral nutrition (with lipids)
injectionCarboplatin Anticancer drug
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
injectionCefazolin sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
injectionCefonicid sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
injectionCefoperazone sodium Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (with lipids)
injectionCefotaxime sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
injectionCefoxitin sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
injectionCeftazidime Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (with lipids)
injectionCeftizoxime sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
injectionCeftriaxone disodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
injectionCefuroxime sodium Antibiotic
Compatible 30 mg/ml + Parenteral nutrition (with lipids)
injectionChlorpromazine hydrochloride Anxiolytic
Compatible 2 mg/ml + Parenteral nutrition (with lipids)
injectionCiclosporin Immunosuppressant
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 5 mg/ml + Parenteral nutrition (with lipids)
injectionCimetidine hydrochloride Antihistamine (H2)
Compatible 12 mg/ml + Parenteral nutrition (with lipids)
injectionCiprofloxacin lactate Antibiotic
Incompatible 1 mg/ml + Parenteral nutrition (with lipids)
injectionCisplatin Anticancer drug
Compatible 1 mg/ml + Parenteral nutrition (with lipids)
injectionClindamycin phosphate Antibiotic
Compatible 10 mg/ml + Parenteral nutrition (with lipids)
injectionCo-trimoxazole Antibiotic
Compatible 0.8/4 mg/ml + Parenteral nutrition (with lipids)
injectionCyclophosphamide Anticancer drug
Compatible 10 mg/ml + Parenteral nutrition (with lipids)
injectionCytarabine Anticancer drug
Compatible 50 mg/ml + Parenteral nutrition (with lipids)
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 1 mg/ml + Parenteral nutrition (with lipids)
injectionDigoxin Cardiotonic
Compatible 250 µg/ml + Parenteral nutrition (with lipids)
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 2 & 50 mg/ml + Parenteral nutrition (with lipids)
injectionDobutamine hydrochloride Cardiotonic
Compatible 4 mg/ml + Parenteral nutrition (with lipids)
injectionDopamine hydrochloride Cardiotonic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 3.2 mg/ml + Parenteral nutrition (with lipids)
injectionDoxorubicin hydrochloride Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 2 mg/ml + Parenteral nutrition (with lipids)
injectionDoxycycline hyclate Antibiotic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 1 mg/ml + Parenteral nutrition (with lipids)
injectionDroperidol Neuroleptic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 0.4 mg/ml + Parenteral nutrition (with lipids)
injectionEnalaprilate Antihypertensive
Compatible 0.1 mg/ml + Parenteral nutrition (with lipids)
injectionFamotidine Antihistamine (H2)
Compatible 2 mg/ml + Parenteral nutrition (with lipids)
injectionFentanyl citrate Analgesic
Compatible 12.5 & 50 µg/ml + Parenteral nutrition (with lipids)
injectionFluconazole Antifungal
Compatible 2 mg/ml + Parenteral nutrition (with lipids)
injectionFluorouracil Anticancer drug
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 16 mg/ml + Parenteral nutrition (with lipids)
injectionFolinate calcium Cytoprotective
Compatible 2 mg/ml + Parenteral nutrition (with lipids)
injectionFurosemide Diuretic
Compatible 3 mg/ml + Parenteral nutrition (with lipids)
injectionGallium nitrate Calcium-lowering agent
Compatible 0.4 mg/ml + Parenteral nutrition (with lipids)
injectionGanciclovir sodium Antiviral
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 20 mg/ml + Parenteral nutrition (with lipids)
injectionGentamicin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
injectionGranisetron hydrochloride Antiemetic
Compatible 0.05 mg/ml + Parenteral nutrition (with lipids)
injectionHaloperidol lactate Neuroleptic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 0.2 mg/ml + Parenteral nutrition (with lipids)
injectionHeparin sodium Anticoagulant
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 100 UI/ml + Parenteral nutrition (with lipids)
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1 mg/ml + Parenteral nutrition (with lipids)
injectionHydromorphone hydrochloride Analgesic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 0.5 mg/ml + Parenteral nutrition (with lipids)
injectionHydroxyzine dihydrochloride Anxiolytic
Compatible 2 mg/ml + Parenteral nutrition (with lipids)
injectionIfosfamide Anticancer drug
Compatible 25 mg/ml + Parenteral nutrition (with lipids)
injectionImipenem - cilastatin sodium Antibiotic
Compatible 10 mg/ml + Parenteral nutrition (with lipids)
injectionInsulin Glucose-lowering
Compatible 1 UI/ml + Parenteral nutrition (with lipids)
injectionLorazepam Anxiolytic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 0.1 mg/ml + Parenteral nutrition (with lipids)
injectionMagnesium sulfate Electrolyte
Compatible 100 mg/ml + Parenteral nutrition (with lipids)
injectionMannitol Various
Compatible 150 mg/ml + Parenteral nutrition (with lipids)
injectionMeropenem Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
injectionMesna Cytoprotective
Compatible 10 mg/ml + Parenteral nutrition (with lipids)
injectionMethotrexate sodium Anticancer drug
Compatible 15 mg/ml + Parenteral nutrition (with lipids)
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
injectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
injectionMidazolam hydrochloride Anxiolytic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 2 mg/ml + Parenteral nutrition (with lipids)
injectionMinocycline hydrochloride Antibiotic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 0.2 mg/ml + Parenteral nutrition (with lipids)
injectionMitoxantrone dihydrochloride Anticancer drug
Compatible 0.5 mg/ml + Parenteral nutrition (with lipids)
injectionMorphine sulfate Analgesic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 15 mg/ml + Parenteral nutrition (with lipids)
Compatible 1 mg/ml + Parenteral nutrition (with lipids)
injectionNafcillin sodium Antibiotic
Compatible 20 mg/ml + Parenteral nutrition (with lipids)
injectionNalbuphine hydrochloride Antidote
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 10 mg/ml + Parenteral nutrition (with lipids)
injectionNetilmicin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
injectionNitroglycerin Vasodilator
Compatible 0.4 mg/ml + Parenteral nutrition (with lipids)
injectionNitroprusside sodium Vasodilator
Compatible 0.4 mg/ml + Parenteral nutrition (with lipids)
injectionOctreotide acetate Various
Compatible 10 mg/ml + Parenteral nutrition (with lipids)
injectionOfloxacin Antibiotic
Compatible 4 mg/ml + Parenteral nutrition (with lipids)
injectionOndansetron hydrochloride Antiemetic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 1 mg/ml + Parenteral nutrition (with lipids)
injectionPaclitaxel Anticancer drug
Compatible 1.2 mg/ml + Parenteral nutrition (with lipids)
injectionPentobarbital sodium General anesthetic
Incompatible 5 mg/ml + Parenteral nutrition (with lipids)
injectionPethidine hydrochloride Analgesic
Compatible 4 mg/ml + Parenteral nutrition (with lipids)
injectionPhenobarbital sodium Antiepileptic
Factors which affect stability Solvent Parenteral nutrition (with lipids) Induces Degradation
Incompatible 5 mg/ml + Parenteral nutrition (with lipids)
injectionPiperacillin sodium Antibiotic
Compatible 40 mg/ml + Parenteral nutrition (with lipids)
injectionPiperacillin sodium / tazobactam Antibiotic
Compatible 40/5 mg/ml + Parenteral nutrition (with lipids)
injectionPotassium chloride Electrolyte
Compatible 100 mEq/l + Parenteral nutrition (with lipids)
injectionPotassium phosphate Electrolyte
Incompatible 3 mmol/ml + Parenteral nutrition (with lipids)
injectionProchlorperazine edysilate Neuroleptic
Compatible 0.5 mg/ml + Parenteral nutrition (with lipids)
injectionPromethazine hydrochloride Antihistamine (H1)
Compatible 2 mg/ml + Parenteral nutrition (with lipids)
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 2 mg/ml + Parenteral nutrition (with lipids)
injectionSodium bicarbonate Electrolyte
Compatible 84 mg/ml + Parenteral nutrition (with lipids)
injectionSodium Phosphate Electrolyte
Incompatible 3 mmol/ml + Parenteral nutrition (with lipids)
injectionTacrolimus Immunosuppressant
Compatible 1000 µg/ml + Parenteral nutrition (with lipids)
injectionTicarcillin / clavulanic acid Antibiotic
Compatible 31 mg/ml + Parenteral nutrition (with lipids)
injectionTobramycin sulfate Antibiotic
Compatible 5 mg/ml + Parenteral nutrition (with lipids)
injectionVancomycin hydrochloride Antibiotic
Compatible 10 mg/ml + Parenteral nutrition (with lipids)
injectionZidovudine Antiviral
Compatible 4 mg/ml + Parenteral nutrition (with lipids)

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