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References   References 1194  
Type : Journal
Research teams : Bloomfield - Schering-Plough Corporation
Authors : Yuen PHC, Taddei CR, Wyka BE, Chaudry IA.
Title : Compatibility and stability of labetolol hydrochloride in commonly used intravenous solutions.
Reference : Am J Hosp Pharm ; 40: 1007-1009. 1983
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Measurement of osmolality PH measurement 
Comments : 
List of drugs
InjectionLabetalol hydrochloride Beta-blocker
Factors which affect stability Solvent NaHCO3 Induces Degradation
Stability in solutions Glass Glucose 5% 2,5 mg/ml 25°C Not specified
72 Hour
Stability in solutions Glass Glucose 5% 2,5 mg/ml 4°C Protect from light
72 Hour
Stability in solutions Glass Ringer’s lactate solution 2,5 mg/ml 25°C Not specified
72 Hour
Stability in solutions Glass Ringer’s lactate solution 2,5 mg/ml 4°C Protect from light
72 Hour
Incompatible 1,25 >> 3,75 mg/ml + InjectionSodium bicarbonate 50 mg/ml + None
Incompatible 1,25 >> 3,75 mg/ml + NaHCO3
InjectionSodium bicarbonate Electrolyte
Incompatible 50 mg/ml + InjectionLabetalol hydrochloride 1,25 >> 3,75 mg/ml + None
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