Last update :
28/04/2024
References   References 1033  
Type : Journal PC : 0.0006830601092896 

Research teams : Bethesda - National Institutes of Health Clinical Center
Authors : Wolfe JL, Thoma LA, Du C, Goldspiel BR, Gallelli JF, Grimes GJ, Potti GK.
Title : Compatibility and stability of vincristine sulfate, doxorubicin hydrochloride, and etoposide in 0.9% sodium chloride injection.
Reference : Am J Health-Syst Pharm ; 56: 985-989. 1999

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products

List of drugs
InjectionDoxorubicin hydrochloride Anticancer drug
InjectionEtoposide Anticancer drug
InjectionVincristine sulfate Anticancer drug
Stability of mixtures
Polyolefine Sodium chloride 0,9% 23°C-25°C With or without light
Injection Vincristine sulfate 0,002 mg/ml
Injection Doxorubicin hydrochloride 0,050 mg/ml
Injection Etoposide 0,250 mg/ml
72 Hour
Polyolefine Sodium chloride 0,9% 23°C-25°C With or without light
Injection Doxorubicin hydrochloride 0,025 mg/ml
Injection Vincristine sulfate 0,001 mg/ml
Injection Etoposide 0,125 mg/ml
96 Hour
Polyolefine Sodium chloride 0,9% 23°C-25°C With or without light
Injection Vincristine sulfate 0,0014 mg/ml
Injection Doxorubicin hydrochloride 0,035 mg/ml
Injection Etoposide 0,175 mg/ml
96 Hour
Polyolefine Sodium chloride 0,9% 31°C-33°C With or without light
Injection Doxorubicin hydrochloride 0,040 mg/ml
Injection Vincristine sulfate 0,0016 mg/ml
Injection Etoposide 0,200 mg/ml
72 Hour

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