Last update :
19/11/2024
References   References 1  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/53/16/1939

Research teams : Foster City - Gilead Sciences
Authors : Yuan LC, Samuels GJ, Visor GC.
Title : Stability of cidofovir in 0.9% sodium chloride and in 5% dextrose injection.
Reference : Am J Health-Syst Pharm ; 53: 1939-1943. 1996

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Degradation products not observed in real conditions

List of drugs
injectionCidofovir Antiviral
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,21 & 8,12 mg/ml 2-8°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,21 & 8,12 mg/ml 30°C Light
24 Hour
Stability in solutions Polypropylene and polyethylene NaCl 0,9% or Glucose 5% 0,21 & 8,12 mg/ml 2-8°C Protect from light
24 Hour
Stability in solutions Polypropylene and polyethylene NaCl 0,9% or Glucose 5% 0,21 & 8,12 mg/ml 30°C Light
24 Hour

  Mentions Légales