Last update :
19/11/2024
References   References 4603  
Type : Journal
Web link : https://journals.sagepub.com/doi/10.1177/0018578719888913

Research teams : Montreal - Centre hospitalier Sainte Justine
Authors : Vallée M, Barthélémy I, Friciu M, Pelletier E, Forest J.M, Benoit F, Leclair G.
Title : Compatibility of Lactated Ringer’s Injection With 94 Selected Intravenous Drugs During Simulated Y-site Administration.
Reference : Hosp Pharm ; 56, 4: 228-234. 2021

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
injectionAcetazolamide Diuretic
Compatible 100 mg/ml + Ringer’s lactate solution
injectionAciclovir sodium Antiviral
Compatible 50 mg/ml + Ringer’s lactate solution
injectionAmikacin sulfate Antibiotic
Compatible 250 mg/ml + Ringer’s lactate solution
injectionAminophylline Various
Compatible 25 mg/ml + Ringer’s lactate solution
injectionAmiodarone hydrochloride Anti-arrhythmic
Compatible 50 mg/ml + Ringer’s lactate solution
injectionAmphotericin B liposomale Antifungal
Compatible 4 mg/ml + Ringer’s lactate solution
injectionAmpicillin sodium Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
injectionAtropine sulfate Antimuscarinic
Compatible 0,4 mg/ml + Ringer’s lactate solution
injectionAzithromycine Antibiotic
Compatible 500 mg/ml + Ringer’s lactate solution
injectionBretylium tosilate Anti-arrhythmic
Compatible 50 mg/ml + Ringer’s lactate solution
injectionBupivacaine hydrochloride Local anesthetic
Compatible 5 mg/ml + Ringer’s lactate solution
injectionCaffeine citrate Respiratory stimulant
Compatible 10 mg/ml + Ringer’s lactate solution
injectionCalcium chloride Electrolyte
Compatible 100 mg/ml + Ringer’s lactate solution
injectionCalcium gluconate Electrolyte
Compatible 100 mg/ml + Ringer’s lactate solution
injectionCaspofungin acetate Antifungal
Compatible 5 mg/ml + Ringer’s lactate solution
injectionCefazolin sodium Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
injectionCefotaxime sodium Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
injectionCefoxitin sodium Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
injectionCeftazidime Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
injectionCeftriaxone disodium Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
injectionCefuroxime sodium Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
injectionChlorpromazine hydrochloride Anxiolytic
Compatible 25 mg/ml + Ringer’s lactate solution
injectionCiclosporin Immunosuppressant
Incompatible 50 mg/ml + Ringer’s lactate solution
injectionCiprofloxacin lactate Antibiotic
Incompatible 2 mg/ml + Ringer’s lactate solution
injectionCloxacillin sodium Antibiotic
Compatible 100 mg/ml + Ringer’s lactate solution
injectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 4 mg/ml + Ringer’s lactate solution
injectionDexmedetomidine Sympathomimetic
Compatible 100 µg/ml + Ringer’s lactate solution
injectionDiazepam Anxiolytic
Incompatible 5 mg/ml + Ringer’s lactate solution
injectionDigoxin Cardiotonic
Compatible 50 µg/ml + Ringer’s lactate solution
injectionDimenhydrinate Antihistamine (H1)
Compatible 10 mg/ml + Ringer’s lactate solution
injectionDiphenhydramine hydrochloride Antihistamine (H1)
Compatible 50 mg/ml + Ringer’s lactate solution
injectionDobutamine hydrochloride Cardiotonic
Compatible 12,5 mg/ml + Ringer’s lactate solution
injectionDopamine hydrochloride Cardiotonic
Compatible 3,2 mg/ml + Ringer’s lactate solution
injectionEnalaprilate Antihypertensive
Compatible 1,25 mg/ml + Ringer’s lactate solution
injectionEpinephrine hydrochloride Sympathomimetic
Compatible 1000 µg/ml + Ringer’s lactate solution
injectionErythromycin lactobionate Antibiotic
Compatible 50 mg/ml + Ringer’s lactate solution
injectionEsmolol hydrochloride Beta-blocker
Compatible 10 mg/ml + Ringer’s lactate solution
injectionFentanyl citrate Analgesic
Compatible 50 µg/ml + Ringer’s lactate solution
injectionFluconazole Antifungal
Compatible 2 mg/ml + Ringer’s lactate solution
injectionFurosemide Diuretic
Compatible 10 mg/ml + Ringer’s lactate solution
injectionGentamicin sulfate Antibiotic
Compatible 10 mg/ml + Ringer’s lactate solution
injectionGranisetron hydrochloride Antiemetic
Compatible 1 mg/ml + Ringer’s lactate solution
injectionHaloperidol lactate Neuroleptic
Compatible 5 mg/ml + Ringer’s lactate solution
injectionHeparin sodium Anticoagulant
Compatible 1000 UI/ml + Ringer’s lactate solution
injectionHuman albumin Various
Compatible 250 mg/ml + Ringer’s lactate solution
injectionHydralazine hydrochloride Antihypertensive
Compatible 20 mg/ml + Ringer’s lactate solution
injectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 50 mg/ml + Ringer’s lactate solution
injectionHydromorphone hydrochloride Analgesic
Compatible 10 mg/ml + Ringer’s lactate solution
injectionHydroxyzine dihydrochloride Anxiolytic
Compatible 50 mg/ml + Ringer’s lactate solution
injectionInsulin Glucose-lowering
Compatible 100 UI/ml + Ringer’s lactate solution
injectionIsoprenaline hydrochloride Beta-stimulant
Compatible 0.2 mg/ml + Ringer’s lactate solution
injectionKetamine hydrochloride General anesthetic
Incompatible 50 mg/ml + Ringer’s lactate solution
injectionLabetalol hydrochloride Beta-blocker
Compatible 5 mg/ml + Ringer’s lactate solution
injectionLidocaine hydrochloride Local anesthetic
Compatible 10 mg/ml + Ringer’s lactate solution
injectionLinezolid Antibiotic
Compatible 2 mg/ml + Ringer’s lactate solution
injectionLorazepam Anxiolytic
Incompatible 4 mg/ml + Ringer’s lactate solution
injectionMagnesium sulfate Electrolyte
Compatible 500 mg/ml + Ringer’s lactate solution
injectionMannitol Various
Compatible 250 mg/ml + Ringer’s lactate solution
injectionMeropenem Antibiotic
Compatible 50 mg/ml + Ringer’s lactate solution
injectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 62,5 mg/ml + Ringer’s lactate solution
injectionMetoclopramide hydrochloride Antiemetic
Compatible 5 mg/ml + Ringer’s lactate solution
injectionMetronidazole Antiparasitic
Compatible 5 mg/ml + Ringer’s lactate solution
injectionMidazolam hydrochloride Anxiolytic
Compatible 5 mg/ml + Ringer’s lactate solution
injectionMilrinone lactate Cardiotonic
Compatible 1 mg/ml + Ringer’s lactate solution
injectionMorphine sulfate Analgesic
Compatible 50 mg/ml + Ringer’s lactate solution
injectionN-acetylcysteine Antidote
Compatible 200 mg/ml + Ringer’s lactate solution
injectionNaloxone hydrochloride Antidote
Compatible 0,4 mg/ml + Ringer’s lactate solution
injectionNicardipine hydrochloride Vasodilator
Compatible 0,2 mg/ml + Ringer’s lactate solution
injectionNitroglycerin Vasodilator
Incompatible 5 mg/ml + Ringer’s lactate solution
injectionNitroprusside sodium Vasodilator
Compatible 25 mg/ml + Ringer’s lactate solution
injectionNorepinephrine bitartrate Sympathomimetic
Compatible 1 mg/ml + Ringer’s lactate solution
injectionOctreotide acetate Various
Compatible 0,5 mg/ml + Ringer’s lactate solution
injectionOxytocin Various
Compatible 10 UI/ml + Ringer’s lactate solution
injectionPenicillin G sodium Antibiotic
Compatible 500 000 MUI/ml + Ringer’s lactate solution
injectionPhenytoin sodium Antiepileptic
Incompatible 50 mg/ml + Ringer’s lactate solution
injectionPiperacillin sodium Antibiotic
Compatible 200 mg/ml + Ringer’s lactate solution
injectionPiperacillin sodium / tazobactam Antibiotic
Compatible 200 mg/ml + Ringer’s lactate solution
injectionPotassium chloride Electrolyte
Compatible 2 mEq/l + Ringer’s lactate solution
injectionPotassium phosphate Electrolyte
Compatible 3 mmol/ml + Ringer’s lactate solution
injectionPropofol General anesthetic
Incompatible 10 mg/ml + Ringer’s lactate solution
injectionRanitidine hydrochloride Antihistamine (H2)
Compatible 25 mg/ml + Ringer’s lactate solution
injectionRocuronium bromide Curarimimetic
Compatible 10 mg/ml + Ringer’s lactate solution
injectionSalbutamol sulfate Beta-stimulant
Compatible 1 mg/ml + Ringer’s lactate solution
injectionSodium bicarbonate Electrolyte
Compatible 1 mg/ml + Ringer’s lactate solution
injectionTobramycin sulfate Antibiotic
Compatible 40 mg/ml + Ringer’s lactate solution
injectionVancomycin hydrochloride Antibiotic
Compatible 50 mg/ml + Ringer’s lactate solution
injectionVerapamil hydrochloride Anti-arrhythmic
Compatible 2,5 mg/ml + Ringer’s lactate solution
injectionVoriconazole Antifungal
Compatible 10 mg/ml + Ringer’s lactate solution

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