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Anticancer drug   Methotrexate sodium  
injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers
Abitrexate Republic of South Africa
Antifolan Romania
Artrait Argentina
Bendatrexat Germany
Biometrox Brazil
Ebetrex Switzerland
Ebetrexate Austria
Emthexat Turkey
Emthexate Belgium, Netherlands, Republic of South Africa, Spain
Ledertrexate Belgium, France, Luxembourg, Morocco
Maxtrex Great Britain
Metex Germany, Norway
Methoblastin Republic of South Africa
Methotrexamed Germany
Methotrexate France
Metoject Chile, Denmark, Finland, France, Great Britain, Netherlands, Spain, Sweden, Switzerland
Metotrexato Chile
Trexan Finland
Trexat Germany
Stability in solutions   injection   Stability in solutions : Methotrexate sodium     
Container Solvent Concentration Temperature Storage Duration of stability References
Glass NaCl 0,9% or Glucose 5% 0,36 mg/ml 23°C Protect from light
72 Hour
1501
Level of evidence A
Glass NaCl 0,9% or Glucose 5% 0,36 mg/ml 4°C Protect from light
72 Hour
1501
Level of evidence A
Glass Sodium chloride 0,9% 1,25 & 12,5 mg/ml 2-8°C Protect from light
105 Day
110
Level of evidence A
Glass Sodium chloride 0,9% 2,5 mg/ml 25°C Light
7 Day
739
Joker
Glass Ringer’s lactate solution 2,5 mg/ml 25°C Light
7 Day
739
Joker
Glass Elliott’s B solution 2 mg/ml 23°C Not specified
48 Hour
31
Joker
Glass Elliott’s B solution 2 mg/ml 4°C Not specified
48 Hour
31
Joker
Glass Elliott’s B solution 2,5 mg/ml 25°C Light
7 Day
739
Joker
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,225 mg/ml 4°C Protect from light
30 Day
162
Level of evidence C
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,36 mg/ml 23°C Protect from light
72 Hour
1501
Level of evidence A
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,36 mg/ml 4°C Protect from light
72 Hour
1501
Level of evidence A
Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,5 mg/ml -20°C Protect from light
30 Day
859
Level of evidence C
Polyvinyl chloride NaCl 0,9% or Glucose 5% 24 mg/ml 4°C Protect from light
30 Day
162
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 0,1 & 1 & 20 mg/ml -20°C Protect from light
84 Day
1021
Level of evidence C
Polyvinyl chloride Sodium chloride 0,9% 1,25 & 12,5 mg/ml 2-8°C Protect from light
105 Day
110
Level of evidence A
Polyethylene NaCl 0,9% or Glucose 5% 0,36 mg/ml 21°C-22°C Not specified
48 Hour
1520
Manufacturer's stability data
Polyethylene NaCl 0,9% or Glucose 5% 0,36 mg/ml 23°C Protect from light
72 Hour
1501
Level of evidence A
Polyethylene NaCl 0,9% or Glucose 5% 0,36 mg/ml 4°C Protect from light
72 Hour
1501
Level of evidence A
Polyethylene NaCl 0,9% or Glucose 5% 0,36 mg/ml 4°C Not specified
48 Hour
1520
Manufacturer's stability data
Polyolefine Sodium chloride 0,9% 0,2 mg/ml 23-27°C Protect from light
28 Day
3980
Level of evidence A
Polyolefine Sodium chloride 0,9% 20 mg/ml 23-27°C Protect from light
28 Day
3980
Level of evidence A
Polyolefine Glucose 5% 0,2 mg/ml 23-27°C Protect from light
3 Day
3980
Level of evidence A
Polyolefine Glucose 5% 20 mg/ml 23-27°C Protect from light
28 Day
3980
Level of evidence A
Polypropylen Syringe Water for Injection 50 mg/ml 25°C Protect from light
70 Day
1155
Level of evidence C
Polypropylen Syringe Elliott’s B solution 2 mg/ml 23°C Not specified
48 Hour
31
Joker
Polypropylen Syringe Elliott’s B solution 2 mg/ml 4°C Protect from light
48 Hour
31
Joker
Polypropylen Syringe None 2,5 mg/ml 25°C Protect from light
7 Day
1469
Level of evidence C
Polypropylen Syringe None 2,5 mg/ml 4°C Protect from light
7 Day
1469
Level of evidence C
Polypropylen Syringe None 25 mg/ml 2-8°C Protect from light
84 Day
3670
Level of evidence A+
Polypropylen Syringe None 25 & 100 mg/ml 2-8°C Protect from light
14 Day
4578
Level of evidence A
Polypropylen Syringe None 25 & 100 mg/ml 21°C Protect from light
14 Day
4578
Level of evidence A
  Mentions Légales